{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T01:09:35Z","timestamp":1768352975888,"version":"3.49.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A series of in-vitro and in-vivo experiments, using various inducers and inhibitors of hepatic microsomal cytochrome P450 (CYP) isozymes, was conducted to study oltipraz pharmacokinetics in rats. In in-vivo studies, oltipraz at a dose of 10 mg kg\u22121 was administered intravenously to rats. In rats pretreated with SKF 525-A (a nonspecific CYP isozyme inhibitor in rats; n = 9), the time-averaged total body clearance (CL) of oltipraz was significantly slower (56.6% decrease) than that in untreated rats (n = 9). This indicated that oltipraz is metabolized via CYP isozymes in rats. Hence, various enzyme inducers or inhibitors were used in in-vitro and in-vivo studies in rats. In rats pretreated with 3-methylcholanthrene (n = 9 and 8 for untreated and treated groups, respectively), phenobarbital (n = 7 and 10 for untreated and treated groups, respectively) or dexamethasone (n = 7 and 12 for untreated and treated groups, respectively) (main inducers of CYP1A1\/2, 2B1\/2 and 3A1\/2 in rats, respectively), the CL values were significantly faster (38.4, 94.4 and 33.6% increase, respectively). In rats pretreated with sulfaphenazole (n = 8 and 9 for untreated and treated groups, respectively), quinine (n = 7 and 9 for untreated and treated groups, respectively) or troleandomycin (n = 8 and 9 for untreated and treated groups, respectively) (main inhibitors of CYP2C11, 2D1 and 3A1\/2 in rats, respectively), the CL values were significantly slower (31.0, 27.6 and 36.3% decrease, respectively). The in-vivo results with various enzyme inhibitors correlated well with the in-vitro intrinsic clearance for disappearance of oltipraz (CLint) (n = 5, each). The above data suggested that oltipraz could be metabolized in male rats mainly via CYP1A1\/2, 2B1\/2, 2C11, 3A1\/2 and 2D1.<\/jats:p>","DOI":"10.1211\/0022357055704","type":"journal-article","created":{"date-parts":[[2005,3,29]],"date-time":"2005-03-29T23:21:19Z","timestamp":1112138479000},"page":"443-452","source":"Crossref","is-referenced-by-count":14,"title":["Effect of enzyme inducers and inhibitors on the pharmacokinetics of oltipraz in rats"],"prefix":"10.1093","volume":"57","author":[{"given":"Soo Kyung","family":"Bae","sequence":"first","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University , San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul, 151-742,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University , San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul, 151-742,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"R & D Center of Pharmaceuticals, Institute of Science & Technology , CJ Corporation, San 522-1, Ichon, Kyunggi-Do 467-810,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taekrho","family":"Kim","sequence":"additional","affiliation":[{"name":"R & D Center of Pharmaceuticals, Institute of Science & Technology , CJ Corporation, San 522-1, Ichon, Kyunggi-Do 467-810,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung Gull","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University , San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul, 151-742,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,4,1]]},"reference":[{"key":"2024103109411417200_cit1","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1016\/0006-2952(87)90450-3","article-title":"Studies on the pregnenolone-16-carbonitrile-inducible form of rat liver microsomal cytochrome P-450 and UDP-glucuronosyl transferase","volume":"36","author":"Arlotto","year":"1987","journal-title":"Biochem. 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