{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:01:38Z","timestamp":1761894098336,"version":"3.28.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The in-vivo \u03b2-adrenoreceptor antagonistic activity of test compounds DPJ 955 and DPJ 890 was assessed against \u03b2-adrenoreceptor agonist (isoprenaline) induced tachycardia in anaesthetized rats. The selectivity to block isoprenaline responses on different \u03b2-adrenoreceptor subtypes (\u03b21, \u03b22 and \u03b23) of the test compounds was carried out on isolated rat right atria, isolated rat uterus and isolated rat colon preparations, respectively. Intravenous injection of isoprenaline alone in anaesthetized rats caused hypotension and tachycardia. DPJ 955 or DPJ 890 alone produced a fall in mean arterial pressure and bradycardia in a dose-dependent manner. Administration of isoprenaline to anaesthetized rats pre-treated with test compounds significantly blocked both the tachycardial and hypotensive responses induced by isoprenaline. The test compounds shifted the concentration response curves of isoprenaline towards the right for isolated rat right atrial preparations, rat uterus and rat colon, indicating \u03b21, \u03b22 and \u03b23 adrenoreceptor blockade, respectively. The selectivity ratio for \u03b21\/\u03b2-adrenoreceptors to DPJ 955 and DPJ 890 was 64.6 and 83.2, respectively. DPJ 890 was more potent in blocking \u03b21-adrenoreceptors and was more selective towards \u03b21 receptors than to other \u03b2-adrenoreceptor subtypes. In conclusion, DPJ 955 and DPJ890 have \u03b2-adrenoreceptor blocking activity with high selectivity for the \u03b21-adrenoreceptor subtype.<\/jats:p>","DOI":"10.1211\/0022357055768","type":"journal-article","created":{"date-parts":[[2005,3,29]],"date-time":"2005-03-29T23:21:19Z","timestamp":1112138479000},"page":"515-520","source":"Crossref","is-referenced-by-count":9,"title":["Selective \u03b21-adrenoreceptor blocking activity of newly synthesized acyl amino-substituted aryloxypropanolamine derivatives, DPJ 955 and DPJ 890, in rats"],"prefix":"10.1093","volume":"57","author":[{"given":"K","family":"Nandakumar","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University , Erandwane, Pune 411 038,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S K","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University , Erandwane, Pune 411 038,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randhir","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University , Erandwane, Pune 411 038,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S L","family":"Bodhankar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University , Erandwane, Pune 411 038,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D P","family":"Jindal","sequence":"additional","affiliation":[{"name":"University Institute of Pharmaceutical Sciences, Panjab University , Chandigarh 160 014,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohane S","family":"Coumar","sequence":"additional","affiliation":[{"name":"University Institute of Pharmaceutical Sciences, Panjab University , Chandigarh 160 014,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Balaraman","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, G.S. Patel Postgraduate Center for Pharmaceutical Education and Research , Vadodara,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S H","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Serum Institute of India , Hadapsar, Pune 411 028,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,4,1]]},"reference":[{"key":"2024103109410700700_cit1","first-page":"2413","article-title":"The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure Arch","volume":"157","author":"","year":"1997","journal-title":"Intern. Med."},{"key":"2024103109410700700_cit2","first-page":"151","article-title":"1999 World Health Organization \u2014 International Society of Hypertension Guidelines for the Management of Hypertension. Guidelines Subcommittee","volume":"17","author":"","year":"1999","journal-title":"J. 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