{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:49:05Z","timestamp":1772815745690,"version":"3.50.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We have studied the cytotoxic activity of extracts and jacaranone from Senecio leucanthemifolius Poiret. Extracts from S. leucanthemifolius were able to inhibit the in-vitro proliferation of a series of human tumour cell lines. The dichloromethane extract demonstrated effective cytotoxic activity with an IC50 of 20.1 \u03bcg mL\u22121 on the large cell carcinoma cell line COR-L23. The ethyl acetate extract showed an IC50 value of 5.0 \u03bcg mL\u22121 and the butanol extract an IC50 value of 6.4 \u03bcg mL\u22121 on the same cell line. A major active constituent of the dichloromethane extract was shown to be jacaranone, which was demonstrated to have a very strong activity against all of the tumour cell lines with IC50 values between 2.86 and 3.85 \u03bcg mL\u22121, although it did not account for all the activity observed. Constituents of S. leucanthemifolius extracts were identified by GC\/MS analysis and NMR.<\/jats:p>","DOI":"10.1211\/0022357056398","type":"journal-article","created":{"date-parts":[[2005,6,14]],"date-time":"2005-06-14T01:33:05Z","timestamp":1118712785000},"page":"897-901","source":"Crossref","is-referenced-by-count":19,"title":["In-vitro antiproliferative effects on human tumour cell lines of extracts and jacaranone from <i>Senecio leucanthemifolius<\/i> Poiret"],"prefix":"10.1093","volume":"57","author":[{"given":"M R","family":"Loizzo","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Calabria , I-87036 Arcavata di Rende, CS,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Tundis","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Calabria , I-87036 Arcavata di Rende, CS,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G A","family":"Statti","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Calabria , I-87036 Arcavata di Rende, CS,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Menichini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Calabria , I-87036 Arcavata di Rende, CS,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Houghton","sequence":"additional","affiliation":[{"name":"Centre for Bioactivity Screening of Natural Products, Faculty of Pharmacy, King's College , FWB, 150 Stamford Street, London SE1 9NH,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,7,1]]},"reference":[{"key":"2024103109412439600_cit1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0378-8741(80)90009-4","article-title":"New anti-tumor drugs from plants","volume":"2","author":"Arcamone","year":"1980","journal-title":"J. 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