{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:26:42Z","timestamp":1765294002636,"version":"3.28.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1999,2,1]],"date-time":"1999-02-01T00:00:00Z","timestamp":917827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study examines the anti-ulcerogenic activity of a chloroform extract of Tanacetum vulgare and purified parthenolide, the major sesquiterpene lactone found in the extract.<\/jats:p>\n               <jats:p>Gastric ulcers induced by oral administration of absolute ethanol to rats were reduced dose-dependently by oral pretreatment of animals with the chloroform extract (2.5\u201380 mg kg\u22121) or parthenolide (5\u201340 mgkg\u22121). When administered 30 min before challenge with the alcohol the protection ranged between 34 and 100% for the extract and 27 and 100% for parthenolide. When the products were administered orally 24h before treatment with ethanol, 40 mg kg\u22121 of the extract and of the lactone reduced the mean ulcer index from 4.8 \u00b1 0.3 for control animals to 1.4 \u00b1 0.2 and 0.5 \u00b1 0.1, respectively. The products also prevented alcohol-induced reduction of the number of sulphydryl groups within the gastric mucosa (50.6 \u00b1 2.3 \u03bcg (mg protein)\u22121 for normal animals compared with 17.7 \u00b1 3.0 \u03bcg (mg protein)\u22121 for alcohol-treated animals). Administration of the extract (80 mg kg\u22121) or parthenolide (40 mg kg\u22121) 24h before ethanol treatment restored the numbers of mucosal -SH groups to values near those found for normal animals.<\/jats:p>\n               <jats:p>These results suggest that the products assayed, in particular parthenolide, might find therapeutic application, although further work is required to establish their profit\/risk ratio.<\/jats:p>","DOI":"10.1211\/0022357991772169","type":"journal-article","created":{"date-parts":[[2003,7,18]],"date-time":"2003-07-18T23:43:52Z","timestamp":1058571832000},"page":"215-219","source":"Crossref","is-referenced-by-count":33,"title":["Effect of the Chloroform Extract of <i>Tanacetum vulgare<\/i> and one of its Active Principles, Parthenolide, on Experimental Gastric Ulcer in Rats"],"prefix":"10.1093","volume":"51","author":[{"given":"Horacio","family":"Tournier","sequence":"first","affiliation":[{"name":"C\u00e1tedra de Farmacolog\u00eda, Falcultad de Ciencias M\u00e9dicas, Universidad Nacional de la Plata , CIC Provincia de Buenos Aires,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Schinella","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Farmacolog\u00eda, Falcultad de Ciencias M\u00e9dicas, Universidad Nacional de la Plata , CIC Provincia de Buenos Aires,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elba M","family":"De Balsa","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Farmacolog\u00eda, Falcultad de Ciencias M\u00e9dicas, Universidad Nacional de la Plata , CIC Provincia de Buenos Aires,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor","family":"Buschiazzo","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Farmacolog\u00eda, Falcultad de Ciencias M\u00e9dicas, Universidad Nacional de la Plata , CIC Provincia de Buenos Aires,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvador","family":"Ma\u00f1ez","sequence":"additional","affiliation":[{"name":"Departament de Farmacolog\u00eda, Facultat de Farm\u00e0cia, Universitat de Val\u00e8ncia ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perla Mordujovich","family":"De Buschiazzo","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Farmacolog\u00eda, Falcultad de Ciencias M\u00e9dicas, Universidad Nacional de la Plata , CIC Provincia de Buenos Aires,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,2,1]]},"reference":[{"key":"2024103110042823000_cit1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/ptr.2650050409","article-title":"Anti-inflammatory and anti-ulcerogenic activities of organic extract of Tanacetum microphyllum in rats","volume":"5","author":"Abad","year":"1991","journal-title":"Phytother. Res."},{"key":"2024103110042823000_cit2","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/0031-9422(89)80150-5","article-title":"Revised structures for guaianolide \u03b1-methylenebutyrolactones from feverfew","volume":"28","author":"Begley","year":"1989","journal-title":"Phytochemistry"},{"key":"2024103110042823000_cit3","first-page":"611","article-title":"Feverfew faces the future","volume":"232","author":"Berry","year":"1984","journal-title":"Pharm. J."},{"key":"2024103110042823000_cit4","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1016\/0031-9422(82)85253-9","article-title":"Sesquiterpene lactones and other constituents from Tanacetum parthenium","volume":"21","author":"Bohlmann","year":"1982","journal-title":"Phytochemistry"},{"key":"2024103110042823000_cit5","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1126\/science.572989","article-title":"High concentrations of glutathione in glandular stomach: possible implications of carcinogenesis","volume":"205","author":"Boyd","year":"1979","journal-title":"Science"},{"key":"2024103110042823000_cit6","first-page":"288","volume-title":"Trease and Evans' Pharmacognosy","author":"Evans","year":"1996","edition":"14th"},{"key":"2024103110042823000_cit7","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1021\/np50070a004","article-title":"The gastric cytoprotective effect of several sesquiterpene lactones","volume":"53","author":"Giordano","year":"1990","journal-title":"J. Nat. Prod."},{"key":"2024103110042823000_cit8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1021\/np50106a010","article-title":"Mucus synthesis and sulphydryl groups in cytoprotection mediated by dehydroleucodine, a sesquiterpene lactone","volume":"57","author":"Guardia","year":"1994","journal-title":"J. Nat. Prod."},{"key":"2024103110042823000_cit9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1476-5381.1994.tb13020.x","article-title":"Toxic inhibition of smooth muscle contractility by plant-derived sesquiterpenes caused by their chemically reactive \u03b1-methylenebutyrolactone functions","volume":"112","author":"Hay","year":"1994","journal-title":"Br. J. Pharmacol."},{"key":"2024103110042823000_cit10","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/bmj.291.6495.569","article-title":"Efficacy of feverfew as prophylactic treatment of migraine","volume":"291","author":"Johnson","year":"1985","journal-title":"Br. Med. J. Clin. Res."},{"key":"2024103110042823000_cit11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"2024103110042823000_cit12","first-page":"319","article-title":"Anti-inflammatory activity of Tanacetum vulgare","volume":"67","author":"Mordujovich-Buschiazzo","year":"1996","journal-title":"Fitoterapia"},{"key":"2024103110042823000_cit13","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/ptr.2650060317","article-title":"Effects of naringenin and quercetin on experimental chronic gastric ulcer in rat. Studies on the histological findings","volume":"6","author":"Motilva","year":"1992","journal-title":"Phytother. 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Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury","volume":"77","author":"Robert","year":"1979","journal-title":"Gastroenterology"},{"key":"2024103110042823000_cit18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1055\/s-2006-958055","article-title":"Recent studies on the zoopharmacognosy, pharmacology and neuro-toxicology of sesquiterpene lactones","volume":"61","author":"Robles","year":"1995","journal-title":"Planta Med."},{"key":"2024103110042823000_cit19","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.2042-7158.1998.tb06924.x","article-title":"Anti-inflammatory principles of South American Tanacetum vulgare","volume":"50","author":"Schinella","year":"1998","journal-title":"J. Pharm. Pharmacol."},{"key":"2024103110042823000_cit20","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","article-title":"Estimation of total, protein-bound, and nonprotein sulphydryl groups in tissue with Ellman's reagent","volume":"25","author":"Sedlak","year":"1968","journal-title":"Anal. Biochem."},{"key":"2024103110042823000_cit21","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1126\/science.7280691","article-title":"Sulphydryl compounds may mediate gastric cytoprotection","volume":"214","author":"Szabo","year":"1981","journal-title":"Science"},{"key":"2024103110042823000_cit22","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1055\/s-2006-957599","article-title":"Inhibition of gastric acid secretion by the aqueous extract and purified extracts of Stachytarphena cayennensis","volume":"63","author":"Vela","year":"1997","journal-title":"Planta Med."}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1211%2F0022357991772169","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/51\/2\/215\/60262555\/0022357991772169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/51\/2\/215\/60262555\/0022357991772169.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T10:37:13Z","timestamp":1730371033000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/51\/2\/215\/6157234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,2,1]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1999,2,1]]},"published-print":{"date-parts":[[1999,2,1]]}},"URL":"https:\/\/doi.org\/10.1211\/0022357991772169","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"type":"print","value":"0022-3573"},{"type":"electronic","value":"2042-7158"}],"subject":[],"published-other":{"date-parts":[[1999,2]]},"published":{"date-parts":[[1999,2,1]]}}}