{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:32:22Z","timestamp":1764995542770,"version":"3.28.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1999,3,1]],"date-time":"1999-03-01T00:00:00Z","timestamp":920246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The peripheral adrenergic effects of orphenadrine, an antiparkinsonian drug, have been evaluated in the rat vas deferens to investigate whether these properties are the same as those of other phencyclidine ligands.<\/jats:p>\n               <jats:p>In the low micromolar range, orphenadrine enhanced electrically-evoked and exogenous noradrenaline contractile responses in the epididymal portion of rat vas deferens. It also induced spontaneous activity that was inhibited by prazosin (1 \u03bcM) but not by atropine (20 nM). It inhibited accumulation of [3H]noradrenaline in rat vas deferens (IC50 = 14.2 \u00b1 2.3 \u03bcM). Orphenadrine competitively inhibited [3H]nisoxetine binding in rat vas deferens membranes (Ki = 1.05 \u00b1 0.20 \u03bcM).<\/jats:p>\n               <jats:p>It can be concluded that orphenadrine, at low micromolar concentrations, interacts with the noradrenaline reuptake system inhibiting its functionality and thus potentiating the effect of noradrenaline.<\/jats:p>","DOI":"10.1211\/0022357991772303","type":"journal-article","created":{"date-parts":[[2003,7,18]],"date-time":"2003-07-18T23:43:52Z","timestamp":1058571832000},"page":"307-312","source":"Crossref","is-referenced-by-count":6,"title":["Assessment of the Adrenergic Effects of Orphenadrine in Rat Vas Deferens"],"prefix":"10.1093","volume":"51","author":[{"given":"D","family":"Pubill","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology and Pharmacognosy, Faculty of Pharmacy, University of Barcelona, Zona Univ . Pedralbes, 08028 Barcelona (BCN),","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"Canudas","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Pharmacognosy, Faculty of Pharmacy, University of Barcelona, Zona Univ . Pedralbes, 08028 Barcelona (BCN),","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Pall\u00e0s","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Pharmacognosy, Faculty of Pharmacy, University of Barcelona, Zona Univ . Pedralbes, 08028 Barcelona (BCN),","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F X","family":"Sureda","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Pharmacognosy, Faculty of Pharmacy, University of Barcelona, Zona Univ . Pedralbes, 08028 Barcelona (BCN),","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Escubedo","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Pharmacognosy, Faculty of Pharmacy, University of Barcelona, Zona Univ . Pedralbes, 08028 Barcelona (BCN),","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Camins","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Pharmacognosy, Faculty of Pharmacy, University of Barcelona, Zona Univ . Pedralbes, 08028 Barcelona (BCN),","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Camarasa","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Pharmacognosy, Faculty of Pharmacy, University of Barcelona, Zona Univ . Pedralbes, 08028 Barcelona (BCN),","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,3,1]]},"reference":[{"key":"2024103110040116500_cit1","first-page":"19","article-title":"Orphenadrine plasma levels and amelioration of extrapyramidal side effects in schizophrenic patients treated with haloperidol","volume":"8","author":"Altamura","year":"1986","journal-title":"Acta Neurol. Napoli"},{"key":"2024103110040116500_cit2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1742-1241.1986.tb07976.x","article-title":"Treatment of Parkinson's disease with orphenadrine alone and in combination with L-dopa","volume":"40","author":"Bassi","year":"1986","journal-title":"Br. J. Clin. 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Pharmacol."},{"key":"2024103110040116500_cit21","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0028-3908(73)90037-3","article-title":"Influence of orphenadrine HCl and its N-demethylated derivatives on the in vitro uptake of noradrenaline and 5-hidroxytryptamine by rat brain slices","volume":"12","author":"Zee","year":"1973","journal-title":"Neuropharmacology"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1211%2F0022357991772303","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/51\/3\/307\/60262331\/0022357991772303.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/51\/3\/307\/60262331\/0022357991772303.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T10:35:41Z","timestamp":1730370941000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/51\/3\/307\/6156797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,3,1]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1999,3,1]]},"published-print":{"date-parts":[[1999,3,1]]}},"URL":"https:\/\/doi.org\/10.1211\/0022357991772303","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"type":"print","value":"0022-3573"},{"type":"electronic","value":"2042-7158"}],"subject":[],"published-other":{"date-parts":[[1999,3]]},"published":{"date-parts":[[1999,3,1]]}}}