{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T04:11:33Z","timestamp":1730434293791,"version":"3.28.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1999,6,1]],"date-time":"1999-06-01T00:00:00Z","timestamp":928195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The decoction of Dalbergia monetaria L. is popularly used in Brazil for the treatment of gastric ulcer and the lyophilized aqueous extract (LAE) of D. monetaria has significant anti-ulcerogenic activity and inhibits gastric ulcer lesions induced by pylorus-ligature, ethanol and hypothermic-restraint stress. This work was conducted to identify the anti-ulcerogenic mechanisms of action of the LAE of D. monetaria. We analysed the effect of the LAE on prostaglandin E2 (PGE2) synthesis and on the characteristics (pH, volume and total acid content) of gastric juice. The antagonism between the LAE and histamine or carbachol was also analysed.<\/jats:p>\n               <jats:p>The LAE increased gastric mucosal PGE2 synthesis compared with control (89.7 \u00b1 21.5 and 52.6 \u00b1 11.8 pg mg\u22121, respectively) as assayed by enzyme immunoassay in the rat stomach. The LAE reduced the total acid content of gastric juice, but did not modify pH or gastric volume significantly, in Shay rats. Dose-response curves to histamine were shifted to the right in guinea-pig isolated right atria (pD2 values were 5.77 \u00b1 0.2 and 5.42 \u00b1 0.3, respectively, in the absence and presence of the LAE), with a significant reduction in maximum response (140 \u00b1 15.1 and 98 \u00b1 13.0, respectively). The same effect was observed when the agonist was isoprenaline. The LAE had no effect on the dose-response curve to carbachol in rat fundus strips.<\/jats:p>\n               <jats:p>Thus, the protective effect of the LAE on induced gastric lesions might be because of synergistic effects, e.g. increased PGE2 synthesis and antagonism of H2 histamine and \u03b2-adrenergic receptors, reducing gastric acid secretion. Increased PGE2 synthesis results in increased protection, and antagonism of H2 histamine and \u03b2-adrenergic receptors reduces aggressive factors against the gastric mucosa.<\/jats:p>","DOI":"10.1211\/0022357991772880","type":"journal-article","created":{"date-parts":[[2003,7,18]],"date-time":"2003-07-18T23:43:52Z","timestamp":1058571832000},"page":"735-740","source":"Crossref","is-referenced-by-count":4,"title":["Anti-ulcerogenic Mechanisms of a Lyophilized Aqueous Extract of <i>Dalbergia monetaria<\/i> L. in Rats, Mice and Guinea-pigs"],"prefix":"10.1093","volume":"51","author":[{"given":"Ricardo H S","family":"Cota","sequence":"first","affiliation":[{"name":"Departamento de Fisiologia e Biof\u00edsica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP) , Campinas, S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dora M","family":"Grassi-Kassisse","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Biof\u00edsica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP) , Campinas, S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina C","family":"Spadari-Bratfisch","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Biof\u00edsica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP) , Campinas, S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba R M","family":"Souza Brito","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Biof\u00edsica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP) , Campinas, S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,6,1]]},"reference":[{"key":"2024103110041546100_cit1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3109\/00365529609031622","article-title":"Gastric acid secretion after depletion of enterochromaffin-like cell histamine. A study with \u03b1-fluoromethylhistidine in rats","volume":"31","author":"Andersson","year":"1996","journal-title":"Scand. J. Gastroenterol."},{"key":"2024103110041546100_cit2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1113\/jphysiol.1981.sp013769","article-title":"The action of \u03b2-adrenoceptor agonists on acid secretion by the rat isolated stomach","volume":"316","author":"Canfield","year":"1981","journal-title":"J. Physiol. Lond."},{"key":"2024103110041546100_cit3","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1139\/y95-018","article-title":"Intraluminal pH modulates gastric prostaglandin synthesis","volume":"73","author":"Curtis","year":"1995","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"2024103110041546100_cit4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0016-5085(95)90296-1","article-title":"Eicosanoids and the gastrointestinal tract","volume":"109","author":"Eberhart","year":"1995","journal-title":"Gastroenterology"},{"key":"2024103110041546100_cit5","doi-asserted-by":"crossref","first-page":"3S","DOI":"10.1007\/BF02214869","article-title":"Pharmacological aspects of acid secretion","volume":"40","author":"Hirschowitz","year":"1995","journal-title":"Dig. Dis. Sciences"},{"key":"2024103110041546100_cit6","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.2042-7158.1997.tb06779.x","article-title":"Effects of selective \u03b2-adrenoceptor antagonists on gastric ulceration in the rat","volume":"49","author":"Kaan","year":"1997","journal-title":"J. Pharm. Pharmacol."},{"key":"2024103110041546100_cit7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1006\/phrs.1996.0099","article-title":"Galanin, galantinde ND galanin (1-14)-[\u03b1-aminobutyric acid]-scyliorhinin-1: structure dependent effects on the rat isolated gastric fundus","volume":"35","author":"Korolkiewicz","year":"1997","journal-title":"Pharmacol. Res."},{"key":"2024103110041546100_cit8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF02003217","article-title":"Mechanism of action of H2 antagonists on histamine or dimaprit-stimulated H2-receptors of spontaneously beating guinea-pig atrium","volume":"31","author":"Krielaart","year":"1990","journal-title":"Agents Actions"},{"key":"2024103110041546100_cit9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0079-6468(08)70365-5","article-title":"Anti-ulcer drugs of plant origin","volume":"28","author":"Lewis","year":"1991","journal-title":"Progress in Medicinal Chemistry"},{"key":"2024103110041546100_cit10","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/ptr.2650070211","article-title":"Quercetin and naringenin: effects on ulcer formation and gastric secretion in rats","volume":"7","author":"Martin","year":"1993","journal-title":"Phytother. Res."},{"key":"2024103110041546100_cit11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0090-6980(96)00052-4","article-title":"Cytoprotective activity of cisapride on experimental gastric mucosal lesions induced by ethanol. Role of endogenous prostaglandins","volume":"52","author":"Motilva","year":"1996","journal-title":"Prostaglandins"},{"key":"2024103110041546100_cit12","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/S0031-9422(00)97940-8","article-title":"Two proanthocyanidins from the bark of Dalbergia monetaria","volume":"28","author":"Nunes","year":"1989","journal-title":"Phytochemistry"},{"volume-title":"Guide to the Care and Use of Experimental Animals","year":"1993","author":"Olfert","key":"2024103110041546100_cit13"},{"key":"2024103110041546100_cit14","first-page":"G1","article-title":"Mild irritants prevent gastric necrosis through \u201cadaptive cytoprotection\u201d mediated by prostaglandins","volume":"245","author":"Robert","year":"1983","journal-title":"Am. J. Physiol."},{"key":"2024103110041546100_cit15","first-page":"81","article-title":"Gastric acid secretion: activation and inhibition","volume":"67","author":"Sachs","year":"1994","journal-title":"Yale J. Biol. Med."},{"key":"2024103110041546100_cit16","first-page":"43","article-title":"A simple method for the uniform production of gastric ulceration in rats","volume":"5","author":"Shay","year":"1945","journal-title":"Gastroenterology"},{"key":"2024103110041546100_cit17","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/(SICI)1099-1573(199706)11:4<314::AID-PTR89>3.0.CO;2-2","article-title":"Gastric anti-ulcerogenic effects of Dalbergia monetaria L. in rats","volume":"11","author":"Brito","year":"1997","journal-title":"Phytother. Res."},{"key":"2024103110041546100_cit18","first-page":"579","article-title":"Etiology and pathology of peptic ulcer","volume-title":"Gastroenterology","author":"Sun","year":"1974"},{"key":"2024103110041546100_cit19","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.2042-7158.1991.tb03461.x","article-title":"Effect of polysaccharide fraction from the roots of Bupleurum falcatum L. on experimental gastric ulcer models in rats and mice","volume":"43","author":"Sun","year":"1991","journal-title":"J. Pharm. Pharmacol."},{"key":"2024103110041546100_cit20","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/0306-3623(95)00037-2","article-title":"Non-steroidal anti-inflammatory drug-induced gastric damage in experimental animals: underlying pathological mechanisms","volume":"26","author":"Threvethick","year":"1995","journal-title":"Gen. Pharmacol."},{"key":"2024103110041546100_cit21","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1476-5381.1957.tb00146.x","article-title":"A sensitive method for the assay of 5-hydroxytryptamine","volume":"12","author":"Vane","year":"1957","journal-title":"Br. J. Pharmacol. Chemother."},{"key":"2024103110041546100_cit22","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1096\/fasebj.10.7.8635690","article-title":"The cellular and molecular basis of gastric mucosal defence","volume":"10","author":"Wallace","year":"1996","journal-title":"FASEB J."},{"key":"2024103110041546100_cit23","first-page":"G462","article-title":"Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process","volume":"259","author":"Wallace","year":"1990","journal-title":"Am. J. Physiol."}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1211%2F0022357991772880","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/51\/6\/735\/60262495\/0022357991772880.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/51\/6\/735\/60262495\/0022357991772880.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T10:36:28Z","timestamp":1730370988000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/51\/6\/735\/6157301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6,1]]},"references-count":23,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1999,6,1]]},"published-print":{"date-parts":[[1999,6,1]]}},"URL":"https:\/\/doi.org\/10.1211\/0022357991772880","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"type":"print","value":"0022-3573"},{"type":"electronic","value":"2042-7158"}],"subject":[],"published-other":{"date-parts":[[1999,6]]},"published":{"date-parts":[[1999,6,1]]}}}