{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:17:49Z","timestamp":1758925069704,"version":"3.28.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1999,6,1]],"date-time":"1999-06-01T00:00:00Z","timestamp":928195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Several compounds of pharmaceutical importance from a variety of chemical families, for example chlorpromazine and clomipramine, have been found to form charge-transfer complexes with iodine. We have investigated the influence of dietary iodine on thyroid-gland dysfunction induced by clomipramine, chlorpromazine or 2-thiazoline-2-thiol. We suggest that iodine is partly diverted from its metabolic pathway by complexation with drugs, and so the urinary concentration of iodide is increased.<\/jats:p>\n               <jats:p>Both chlorpromazine and clomipramine, at doses which do not inhibit thyroperoxidase, enhanced urinary iodine excretion when dietary iodine was restricted (3.94 \u00b1 0.96 \u03bcg\/day for chlorpromazine-tested rats, 3.43 \u00b1 1.33 \u03bcg\/day for clomipramine-tested rats, compared with 2.34 \u00b1 0.11 \u03bcg\/day in control rats). Concurrently, these pharmaceutical compounds increased the level of free thyroid-stimulating hormone (TSH) in comparison with controls and induced histological modifications in, and enlargement of, the thyroid gland.<\/jats:p>\n               <jats:p>We have demonstrated that drug-induced loss of iodine in the urine was associated with antithyroid action when iodine intake was limited.<\/jats:p>","DOI":"10.1211\/0022357991772907","type":"journal-article","created":{"date-parts":[[2003,7,18]],"date-time":"2003-07-18T23:43:52Z","timestamp":1058571832000},"page":"745-750","source":"Crossref","is-referenced-by-count":5,"title":["Influence of Dietary Iodine on Drug-induced Hypothyroidism in the Rat"],"prefix":"10.1093","volume":"51","author":[{"given":"M L","family":"Beyssen","sequence":"first","affiliation":[{"name":"Department of Chemical Pharmacy, Faculty of Pharmacy , 87025 Limoges,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J F","family":"Lagorce","sequence":"additional","affiliation":[{"name":"Department of Chemical Pharmacy, Faculty of Pharmacy , 87025 Limoges,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Cledat","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy , 87025 Limoges,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Buxeraud","sequence":"additional","affiliation":[{"name":"Department of Chemical Pharmacy, Faculty of Pharmacy , 87025 Limoges,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,6,1]]},"reference":[{"key":"2024103110041947400_cit1","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/clinchem\/9.4.408","article-title":"Protein-bound iodine, total iodine, and butanol-extractable iodine by partial automation","volume":"4","author":"Benotti","year":"1963","journal-title":"Clin. Chem."},{"key":"2024103110041947400_cit2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0378-4274(92)90211-2","article-title":"Pathophysiology of chemical injury of the thyroid gland","volume":"64\/65","author":"Capen","year":"1992","journal-title":"Toxicol. Lett."},{"key":"2024103110041947400_cit3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0167-5699(96)10073-6","article-title":"Searching for pathogenic epitopes in thyroglobulin: parameters and caveats","volume":"18","author":"Carayanniotis","year":"1997","journal-title":"Immunol. Today"},{"key":"2024103110041947400_cit4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.2042-7158.1994.tb03719.x","article-title":"Antithyroid action of ketoconazole: in-vitro studies and rat in-vivo studies","volume":"46","author":"Comby","year":"1994","journal-title":"J. Pharm. 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Austriaca"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1211%2F0022357991772907","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/51\/6\/745\/60262636\/0022357991772907.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/51\/6\/745\/60262636\/0022357991772907.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T10:36:36Z","timestamp":1730370996000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/51\/6\/745\/6157326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6,1]]},"references-count":26,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1999,6,1]]},"published-print":{"date-parts":[[1999,6,1]]}},"URL":"https:\/\/doi.org\/10.1211\/0022357991772907","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"type":"print","value":"0022-3573"},{"type":"electronic","value":"2042-7158"}],"subject":[],"published-other":{"date-parts":[[1999,6]]},"published":{"date-parts":[[1999,6,1]]}}}