{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:29:49Z","timestamp":1760099389793,"version":"3.28.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>HA-1\u201392, a new polyene oxohexaene macrolide antibiotic isolated from Streptomyces CDRIL-312, was incorporated into liposomes containing phosphotidyl choline and cholesterol.<\/jats:p>\n               <jats:p>The liposomal incorporated HA-1\u201392 considerably decreased toxicity when compared with free HA-1\u201392 in mice. Liposomal HA-1\u201392 showed improved pharmacokinetic profiles in rats. When administered to aspergillosis- and cryptococcosis-infected Balb\/c mice, liposomal HA-1\u201392 showed increased antifungal activity, compared with free HA-1\u201392, with improved survival rate and decreased colony-forming units in lung, liver, spleen and kidney.<\/jats:p>\n               <jats:p>These results suggest that liposomal HA-1\u201392 is more effective than free HA-1\u201392 in controlling experimental aspergillosis and cryptococcosis in Balb\/c mice.<\/jats:p>","DOI":"10.1211\/0022357991773122","type":"journal-article","created":{"date-parts":[[2003,7,18]],"date-time":"2003-07-18T23:43:52Z","timestamp":1058571832000},"page":"771-776","source":"Crossref","is-referenced-by-count":5,"title":["Preparation, Relative Toxicity and Therapeutic Efficacy in Mice and Rats of Liposomal HA-1\u201392, a New Oxohexaene Polyene Macrolide Antibiotic"],"prefix":"10.1093","volume":"51","author":[{"given":"Jyoti","family":"Harindran","sequence":"first","affiliation":[{"name":"Research and Development Division, Hindustan Antibiotics Ltd , Pimpri, Pune 411018,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kishor K","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Research and Development Division, Hindustan Antibiotics Ltd , Pimpri, Pune 411018,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh R","family":"Naik","sequence":"additional","affiliation":[{"name":"Research and Development Division, Hindustan Antibiotics Ltd , Pimpri, Pune 411018,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,7,1]]},"reference":[{"key":"2024103110044533000_cit1","first-page":"351","article-title":"Liposomal amphotericin B in the control of experimental aspergillosis in mice: part I. Relative therapeutic efficacy of free and liposomal amphotericin B","volume":"26","author":"Ahmad","year":"1989","journal-title":"Indian J. Biochem. Biophys"},{"key":"2024103110044533000_cit2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2165\/00003495-199700544-00004","article-title":"Liposomes: opportunities in drug delivery","volume":"54","author":"Allen","year":"1997","journal-title":"Drugs"},{"key":"2024103110044533000_cit3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0169-409X(95)00029-7","article-title":"Pharmacokinetics of long circulating liposomes","volume":"16","author":"Allen","year":"1995","journal-title":"Adv. Drug Delivery Rev"},{"key":"2024103110044533000_cit4","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0022-2836(65)80093-6","article-title":"Diffusion of univalent ions across the lamellae of swollen phospholipids","volume":"13","author":"Bangham","year":"1965","journal-title":"J. Mol. Biol."},{"key":"2024103110044533000_cit5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF01868485","article-title":"Further studies on the charge-related alterations of methotrexate transport in Ehrlich ascites tumor cells by ionic liposomes: correlation with liposome cell association","volume":"66","author":"Fry","year":"1982","journal-title":"J. Membr. Biol."},{"key":"2024103110044533000_cit6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF01868944","article-title":"Alterations of the carrier mediated transport of an anionic solute, methotroxate, by charged liposomes in Ehrlich ascites tumor cells","volume":"50","author":"Fry","year":"1979","journal-title":"J. Membr. Biol."},{"key":"2024103110044533000_cit7","first-page":"147","volume-title":"Amphotericin B-lipid complex in treatment of cryptococcal meningitis in patients with AIDS","author":"Graybill","year":"1991"},{"key":"2024103110044533000_cit8","article-title":"Fermentation, Chemistry and Pharmacology of New Microbial Products of Soil Origin","volume-title":"Ph.D. Thesis","author":"Harindran","year":"1996"},{"key":"2024103110044533000_cit9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0005-2736(93)90105-9","article-title":"Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphopathic weak bases","volume":"1151","author":"Haran","year":"1993","journal-title":"Biochim. Biophys. Acta."},{"key":"2024103110044533000_cit10","first-page":"S8","article-title":"Pharmacokinetics of liposomal amphotericin B (Ambisome) versus other lipid based formulations","volume":"14","author":"Heinemann","year":"1994","journal-title":"Bone Marrow Transplant"},{"key":"2024103110044533000_cit11","first-page":"109","article-title":"Liposome pharmacokinetics","volume-title":"Liposomes: from Biophysics to Theraputics","author":"Hwang","year":"1987"},{"key":"2024103110044533000_cit12","first-page":"99","article-title":"Simplified method of evaluating dose effect experiments","volume":"96","author":"Litchfield","year":"1949","journal-title":"J. Pharmacol. Exp. Therap"},{"key":"2024103110044533000_cit13","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1128\/AAC.31.5.675","article-title":"Liposome as carriers of antimicrobial agent","volume":"31","author":"Berestein","year":"1987","journal-title":"Antimicrob. Agents Chemother"},{"key":"2024103110044533000_cit14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1089\/cdd.1984.1.199","article-title":"Altered tissue distribution of amphotericin B by liposomal encapsulation - comparison of normal mice to infected mice with Candida albicans","volume":"1","author":"Berestein","year":"1984","journal-title":"Cancer Drug Delivery"},{"key":"2024103110044533000_cit15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1259\/0007-1285-58-685-35","article-title":"Technetium-labelled liposome imaging for deep seated injection","volume":"58","author":"Margan","year":"1985","journal-title":"Br. J. Radiol"},{"key":"2024103110044533000_cit16","first-page":"627","article-title":"Structural features determining the haemolytic activity of vacidin A derivatives","volume":"12","author":"Mazerski","year":"1986","journal-title":"Drug Exp. Clin. Res."},{"key":"2024103110044533000_cit17","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1093\/infdis\/164.5.1003","article-title":"Liposomal hamycin: reduced toxicity and improved antifungal efficacy in vitro and in vivo","volume":"164","author":"Mehta","year":"1991","journal-title":"J. Infect. Dis."},{"key":"2024103110044533000_cit18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3109\/10611869308996071","article-title":"Mannosylated liposomes as carriers for hamycin in the treatment of experimental aspergillus in Balb\/c mice","volume":"1","author":"Moonis","year":"1993","journal-title":"J. Drug Target"},{"key":"2024103110044533000_cit19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3109\/09687687809064157","article-title":"Interaction of phospholipid vesicles with murine lymphocytes II. Correlation between altered surface properties and enhanced proliferative response","volume":"1","author":"Ozato","year":"1978","journal-title":"Memb. Biochem"},{"key":"2024103110044533000_cit20","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.bb.07.060178.002251","article-title":"Interaction of phospholipid vesicles with mammalian cells","volume":"7","author":"Pagano","year":"1978","journal-title":"A. Rev. Biophys. Bioeng"},{"key":"2024103110044533000_cit21","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0163-4453(96)91343-2","article-title":"Visceral leishmaniasis in HIV infected patients: treatment with high dose liposomal amphotericin B (Ambisome)","volume":"32","author":"Russo","year":"1996","journal-title":"J. Infect"},{"key":"2024103110044533000_cit22","first-page":"227","volume-title":"Statistical Methods","author":"Snedecor","year":"1968"},{"key":"2024103110044533000_cit23","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/257802a0","article-title":"Interaction between lectin from Ricinus communis and liposomes containing gangliosides","volume":"257","author":"Surolia","year":"1975","journal-title":"Nature"},{"key":"2024103110044533000_cit24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00007890-199501150-00009","article-title":"Liposomal amphotericin B prevents invasive fungal infections in liver transplant recipients: a randomized, placebo controlled study","volume":"59","author":"Tollemar","year":"1995","journal-title":"Transplantation"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1211%2F0022357991773122","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/51\/7\/771\/60262873\/0022357991773122.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/51\/7\/771\/60262873\/0022357991773122.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T10:39:20Z","timestamp":1730371160000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/51\/7\/771\/6157357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7,1]]},"references-count":24,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1999,7,1]]},"published-print":{"date-parts":[[1999,7,1]]}},"URL":"https:\/\/doi.org\/10.1211\/0022357991773122","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"type":"print","value":"0022-3573"},{"type":"electronic","value":"2042-7158"}],"subject":[],"published-other":{"date-parts":[[1999,7]]},"published":{"date-parts":[[1999,7,1]]}}}