{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T04:11:20Z","timestamp":1730434280441,"version":"3.28.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[1999,8,1]],"date-time":"1999-08-01T00:00:00Z","timestamp":933465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A neuroprotective effect can be obtained with N-[(4-cycloheptylaminopyrid-3-yl)sulphonyl]N\u2032-cycloheptyl urea (BM27), a pyrid-3-yl-sulphonylurea structurally related to torasemide, a loop diuretic. We have investigated the neuroprotective effect of BM27 by magnetic resonance imaging and use of the photothrombotic model of cerebral infarction in the rat. This method enables non-invasive quantification of the extent of the cerebral oedema from T2-weighted spin-echo images.<\/jats:p>\n               <jats:p>This article reports the evolution of the extent of oedema with time (0.5, 1, 2, 4, 6, 24 and 48 h, 7 and 15 days and 1 month after induction of the lesion) in rats pretreated with 5mg kg\u22121 BM27 or an appropriate control. At all times, the rats treated with BM27 had, on average, smaller lesions than control rats (30% decrease between 2 h and 6 h).<\/jats:p>\n               <jats:p>These results strongly suggest a significant (P &amp;lt; 0.01) but modest neuroprotective effect of BM27 in ischaemic cerebral stroke. Further investigations should be performed to determine if BM27 or its analogues are of clinical interest.<\/jats:p>","DOI":"10.1211\/0022357991773249","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T22:04:05Z","timestamp":1033509845000},"page":"967-970","source":"Crossref","is-referenced-by-count":0,"title":["Evidence for a Neuroprotective Effect of Pyrid-3-yl-sulphonylurea in Photochemically Induced Focal Ischaemia in Rats: Magnetic Resonance Imaging Evaluation"],"prefix":"10.1093","volume":"51","author":[{"given":"Christine","family":"Baudelet","sequence":"first","affiliation":[{"name":"Laboratory of Medicinal Chemistry and Radiopharmacy, Universit\u00e9 Catholique de Louvain , 1200 Brussels,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Demeure","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Magnetic Resonance, Universit\u00e9 Catholique de Louvain , 1200 Brussels,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Frois","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Magnetic Resonance, Universit\u00e9 Catholique de Louvain , 1200 Brussels,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Masereel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, FUNDP , Namur,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Goudemant","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Magnetic Resonance, Universit\u00e9 Catholique de Louvain , 1200 Brussels,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Ritter","sequence":"additional","affiliation":[{"name":"Institute of Statistics, Universit\u00e9 Catholique de Louvain , 1348 Louvain-la-Neuve,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Gallez","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal Chemistry and Radiopharmacy, Universit\u00e9 Catholique de Louvain , 1200 Brussels,","place":["Belgium"]},{"name":"Laboratory of Biomedical Magnetic Resonance, Universit\u00e9 Catholique de Louvain , 1200 Brussels,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,8,1]]},"reference":[{"key":"2024103110044267700_cit1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/0730-725X(92)90411-R","article-title":"Application of magnetic resonance imaging to the measurement of neurodegeneration in rat brain: MRI data correlate strongly with histology and enzymatic analysis","volume":"10","author":"Allegrini","year":"1992","journal-title":"Magn. 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