{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:05:30Z","timestamp":1765886730355,"version":"3.28.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[1999,9,1]],"date-time":"1999-09-01T00:00:00Z","timestamp":936144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To determine whether biological maturation influences the kinetics of carbamazepineserum protein binding, the carbamazepine free fraction (%) was investigated in the serum of 66 patients, ranging from 4 to 83 years, with epilepsy or trigeminal neuralgia, treated with carbamazepine alone or carbamazepine in combination with phenytoin, phenobarbital, and\/or valproic acid, over a relatively long period.<\/jats:p>\n               <jats:p>Biochemical parameters such as levels of albumin and non-glycated albumin showed a significant relationship with carbamazepine free fraction (r=-0.521, P &amp;lt; 0.001 for albumin; r=-0.700, P &amp;lt; 0.001 for non-glycated albumin). Non-glycated albumin was more strongly correlated with carbamazepine free fraction. The biochemical parameters showed a significant relationship with age (r=-0.243, P &amp;lt; 0.1 for albumin; r= 0.666, P &amp;lt; 0.001 for glycated albumin; r=-0.459, P &amp;lt; 0.001 for non-glycated albumin; r= 0.640, P &amp;lt; 0.001 for carbamazepine free fraction). Glycated albumin (%), non-glycated albumin and carbamazepine free fraction (%) were strongly correlated with age, whereas albumin showed only a weak correlation with age. To evaluate the effects of ageing on carbamazepine-serum protein binding, the patients were divided into three groups according to age: children, 4\u201315 years; adults, 16\u201364 years; elderly, 65\u201383 years. Albumin and non-glycated albumin were much lower, and glycated albumin (%) and carbamazepine free fraction (%) much higher in the elderly group than in the other two groups.<\/jats:p>\n               <jats:p>The results of this study showed that the major ligand of carbamazepine in the serum was non-glycated albumin, which decreased with age. These observations suggested that in elderly patients, the elevation of free carbamazepine concentrations in the serum caused by reduced non-glycated albumin levels, induces increases in the sensitivity of the pharmacological effects of carbamazepine and the risk of drug interactions.<\/jats:p>","DOI":"10.1211\/0022357991773474","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T22:04:05Z","timestamp":1033509845000},"page":"1009-1014","source":"Crossref","is-referenced-by-count":19,"title":["Age-related Alteration of Carbamazepine-serum Protein Binding in Man"],"prefix":"10.1093","volume":"51","author":[{"given":"Hikaru","family":"Koyama","sequence":"first","affiliation":[{"name":"Department of Hospital Pharmacy, Kyoto Prefectural University of Medicine , Kamigyo-ku, Kyoto 6020841,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Sugioka","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmacy, Kyoto Prefectural University of Medicine , Kamigyo-ku, Kyoto 6020841,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Uno","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Pharmacokinetics, Kyoto Pharmaceutical University , Yamashina-ku, Kyoto 607,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Neurology and Gerontology, Kyoto Prefectural University of Medicine , Kamigyo-ku, Kyoto 6020841,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Neurology and Gerontology, Kyoto Prefectural University of Medicine , Kamigyo-ku, Kyoto 6020841,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,9,1]]},"reference":[{"key":"2024103110043244500_cit1","doi-asserted-by":"crossref","first-page":"5176","DOI":"10.1016\/S0021-9258(19)69382-8","article-title":"Non-enzymatic glycosylation of bovine lens crystallin","volume":"256","author":"Chiou","year":"1981","journal-title":"J. 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