{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T04:11:20Z","timestamp":1730434280762,"version":"3.28.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[1999,9,1]],"date-time":"1999-09-01T00:00:00Z","timestamp":936144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The absorption of YJA-20379-8 (3-butyryl-4-[5-(R)-(+)-methylbenzylamino]-8-ethoxy-1,7-naphthyridine) from various rat gastrointestinal segments was evaluated using in-situclosed-loops. The pharmacokinetics of the drug were also evaluated after oral administration to rats with acetic acid-induced gastric ulcer (AIURs). The concentrations of YJA-20379-8 in the biological samples were analyzed by HPLC.<\/jats:p>\n               <jats:p>The absorption of YJA-20379-8 from stomach and jejunum was fast, but approximately 50% of the drug was recovered from each segment at 24 h. The total areas under the plasma concentration-time curves from time zero to 24 h (AUC0-24h) were 161, 392, 233, 365, and 226 \u03bcg min mL\u22121 for stomach, duodenum, jejunum, ileum, and colon, respectively. After oral administration of the drug, the plasma concentrations and the resultant AUC0-12h were not significantly different between control and AIURs. The detection limits of YJA-20379-8 in human plasma and urine were 50 and 100ng mL\u22121, respectively.<\/jats:p>\n               <jats:p>The results suggest that modification of the oral dose of YJA-20379-8 may not be required in gastric ulcer patients if the present rat pharmacokinetic data could be extrapolated to man.<\/jats:p>","DOI":"10.1211\/0022357991773500","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T22:04:05Z","timestamp":1033509845000},"page":"1025-1030","source":"Crossref","is-referenced-by-count":4,"title":["Gastrointestinal Absorption of a New Reversible Proton Pump Inhibitor, YJA-20379-8, and its Pharmacokinetics after Oral Administration in Acetic Acid-induced Gastric Ulcer in Rats"],"prefix":"10.1093","volume":"51","author":[{"given":"Su Y","family":"Chung","sequence":"first","affiliation":[{"name":"College of Pharmacy, Seoul National University , San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kye S","family":"Han","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Seoul National University , San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho J","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Seoul National University , San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonghan","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Seoul National University , San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man S","family":"Chang","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Laboratory, Yung Jin Pharmaceutical Company, Ltd , 470-5, Musong-Ri, Namyang-Myun, Hwasung-Si, Kyunggi-Do 445-850,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung G","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Seoul National University , San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,9,1]]},"reference":[{"key":"2024103110044894900_cit1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0378-4347(00)84213-9","article-title":"Sensitive and rapid high-performance liquid chromatographic method for the simultaneous determination of methotrexate and its metabolite in plasma, saliva and urine","volume":"226","author":"Chen","year":"1981","journal-title":"J. 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