{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T04:11:27Z","timestamp":1730434287023,"version":"3.28.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We have investigated the effect of the newly synthesized proton-pump inhibitor YJA20379-8, 3-butyryl-4-[R-1-methylbenzylamino]-8-ethoxy-1,7-naphthyridine, on gastric mucosal proton pump (H+\/K+-ATPase) activity, gastric acid secretion and gastric lesions in experimental animals.<\/jats:p>\n               <jats:p>In lyophilized pig gastric microsomes, YJA20379-8 was shown to inhibit H+\/K+-ATPase activity; the inhibitory effect was not affected by pH, the IC50 (dose resulting in 50% inhibition) being 28.0 \u03bcM and 30.0 \u03bcM at pH 6.4 and pH 7.4, respectively. The effect was fully reversed by dilution and subsequent washing of the incubation mixtures of H+\/K+-ATPase and YJA20379-8, suggesting the reversible nature of the enzyme inhibition. In pylorus-ligated rats, YJA20379-8 administered by different routes (intraduodenal, subcutaneous, intravenous or oral) resulted in dose-dependent suppression of basal gastric acid secretion. The duration of antisecretory action of 30 mg kg\u22121 YJA20379-8 given intraduodenally was very brief (less than 7 h). Pretreatment with YJA20379-8 also dose-dependently prevented gastric lesions induced by absolute ethanol and water-immersion stress in rats.<\/jats:p>\n               <jats:p>These results suggest that YJA20379-8 might exert its antiulcer activity partly by reversible suppression of acid secretion and partly by protecting the gastric mucosa against ulcerative stimuli.<\/jats:p>","DOI":"10.1211\/0022357991777173","type":"journal-article","created":{"date-parts":[[2003,7,18]],"date-time":"2003-07-18T23:43:52Z","timestamp":1058571832000},"page":"1359-1365","source":"Crossref","is-referenced-by-count":3,"title":["Biochemical and Pharmacological Characteristics of a Newly Synthesized H+\/K+-ATPase Inhibitor, YJA20379-8, 3-Butyryl-4-[<i>R<\/i>-1-methylbenzylamino]-8-ethoxy-1,7-naphthyridine, in pigs and rats"],"prefix":"10.1093","volume":"51","author":[{"given":"Sang Kwon","family":"Sohn","sequence":"first","affiliation":[{"name":"Pharmacology and Toxicology Laboratory, Research and Development Centre, Yung-Jin Pharmaceutical Co. Ltd , 470-5 Musong-Ri, Namyang-Myun, Hwasung-Kun, Kyunggi-Do 445-850,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man Sik","family":"Chang","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Laboratory, Research and Development Centre, Yung-Jin Pharmaceutical Co. Ltd , 470-5 Musong-Ri, Namyang-Myun, Hwasung-Kun, Kyunggi-Do 445-850,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wahn Soo","family":"Choi","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Laboratory, Research and Development Centre, Yung-Jin Pharmaceutical Co. Ltd , 470-5 Musong-Ri, Namyang-Myun, Hwasung-Kun, Kyunggi-Do 445-850,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Kuk","family":"Chung","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Laboratory, Research and Development Centre, Yung-Jin Pharmaceutical Co. Ltd , 470-5 Musong-Ri, Namyang-Myun, Hwasung-Kun, Kyunggi-Do 445-850,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu Bong","family":"Kim","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Laboratory, Research and Development Centre, Yung-Jin Pharmaceutical Co. Ltd , 470-5 Musong-Ri, Namyang-Myun, Hwasung-Kun, Kyunggi-Do 445-850,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Wook","family":"Woo","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Laboratory, Research and Development Centre, Yung-Jin Pharmaceutical Co. Ltd , 470-5 Musong-Ri, Namyang-Myun, Hwasung-Kun, Kyunggi-Do 445-850,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok Bong","family":"Lee","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Laboratory, Research and Development Centre, Yung-Jin Pharmaceutical Co. Ltd , 470-5 Musong-Ri, Namyang-Myun, Hwasung-Kun, Kyunggi-Do 445-850,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong Jeun","family":"Park","sequence":"additional","affiliation":[{"name":"Drug Targeting Laboratory, College of Pharmacy, SungKyunKwan University , 300 Chunchun-Dong, Jangan-Ku, Suwon City, Kyunggi-Do 440-746,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,12,1]]},"reference":[{"key":"2024103110045686900_cit1","first-page":"G165","article-title":"Probes of parietal cell function","volume":"238","author":"Berglindh","year":"1980","journal-title":"Am. J. Physiol"},{"key":"2024103110045686900_cit2","first-page":"187","article-title":"Stability, blood, partition, and pharmacokinetics of a new proton pump inhibitor, YJA20379-8","volume":"100","author":"Chung","year":"1998","journal-title":"Res. Commun. Mol. Pathol. Pharmacol"},{"key":"2024103110045686900_cit3","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1211\/0022357991773500","article-title":"Gastrointestinal absorption of a new reversible proton pump inhibitor, YJA20379-8, in rats and its pharmacokinetics after oral administration to rats with acetic acid-induced gastric ulcer","volume":"51","author":"Chung","year":"1999","journal-title":"J. Pharm. Pharmacol"},{"key":"2024103110045686900_cit4","first-page":"243","article-title":"Omeprazole heals duodenal, but not gastric ulcers more rapidly than ranitidine. Results of two German multicentre trials","volume":"32","author":"Classen","year":"1985","journal-title":"Hepatogastroenterology"},{"key":"2024103110045686900_cit5","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0021-9258(18)84756-1","article-title":"The colorimetric determination of phosphorus","volume":"66","author":"Fiske","year":"1925","journal-title":"J. Biol. 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Acta."},{"key":"2024103110045686900_cit17","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev.pa.28.040188.001413","article-title":"Gastric H+\/K+-ATPase as therapeutic target","volume":"28","author":"Sachs","year":"1988","journal-title":"Annu. Rev. Pharmacol. 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