{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T03:36:47Z","timestamp":1774409807818,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Xanthones are simple three-membered ring compounds that are mainly found as secondary metabolites in higher plants and microorganisms. Xanthones have very diverse biological profiles, including antihypertensive, antioxidative, antithrombotic and anticancer activity, depending on their diverse structures, which are modified by substituents on the ring system. Although several reviews have already been published on xanthone compounds, few of them have focused on the anticancer activity of xanthone derivatives. In this review we briefly summarize natural and synthetic xanthone compounds which have potential as anticancer drugs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>The interesting structural scaffold and pharmacological importance of xanthone derivatives have led many scientists to isolate or synthesize these compounds as novel drug candidates. In the past, extensive research has been conducted to obtain xanthone derivatives from natural resources as well as through synthetic chemistry. Xanthones interact with various pharmacological targets based on the different substituents on the core ring. The anticancer activities of xanthones are also dramatically altered by the ring substituents and their positions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>The biological activities of synthetic xanthone derivatives depend on the various substituents and their position. Study of the biological mechanism of action of xanthone analogues, however, has not been conducted extensively compared to the diversity of xanthone compounds. Elucidation of the exact biological target of xanthone compounds will provide better opportunities for these compounds to be developed as potent anticancer drugs. At the same time, modification of natural xanthone derivatives aimed at specific targets is capable of expanding the biological spectrum of xanthone compounds.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1211\/jpp.61.06.0002","type":"journal-article","created":{"date-parts":[[2010,10,14]],"date-time":"2010-10-14T13:12:34Z","timestamp":1287061954000},"page":"707-712","source":"Crossref","is-referenced-by-count":119,"title":["Recent cancer drug development with xanthone structures"],"prefix":"10.1093","volume":"61","author":[{"given":"Younghwa","family":"Na","sequence":"first","affiliation":[{"name":"College of Pharmacy, Catholic University of Daegu , Gyeongsan, Gyeongbuk,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,6,1]]},"reference":[{"key":"2024103109372437300_cit1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2174\/187152106774755563","article-title":"Pharmacological and biological activities of xanthones","volume":"5","author":"Fotie","year":"2006","journal-title":"Anti-infect Agents Med Chem"},{"key":"2024103109372437300_cit2","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.2174\/092986705774370736","article-title":"Synthesis of xanthones: an overview","volume":"12","author":"Sousa","year":"2005","journal-title":"Curr Med Chem"},{"key":"2024103109372437300_cit3","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.2174\/092986705774370682","article-title":"Naturally-occurring xanthones: recent developments","volume":"12","author":"Vieira","year":"2005","journal-title":"Curr Med Chem"},{"key":"2024103109372437300_cit4","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.2174\/092986705774370727","article-title":"Xanthones \u2013 a structural perspective","volume":"12","author":"Gales","year":"2005","journal-title":"Curr Med Chem"},{"key":"2024103109372437300_cit5","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.2174\/092986705774370709","article-title":"Xanthones as antimalarial agents: discovery, mode of action, and optimization","volume":"12","author":"Riscoe","year":"2005","journal-title":"Curr Med Chem"},{"key":"2024103109372437300_cit6","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0031-9422(00)00303-4","article-title":"Tetraoxygenated naturally occurring xanthones","volume":"55","author":"Peres","year":"2000","journal-title":"Phytochemistry"},{"key":"2024103109372437300_cit7","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.2174\/092986705774370691","article-title":"Xanthone derivatives: new insights in biological activities","volume":"12","author":"Pinto","year":"2005","journal-title":"Curr Med Chem"},{"key":"2024103109372437300_cit8","doi-asserted-by":"crossref","first-page":"5467","DOI":"10.1016\/j.bmc.2006.04.044","article-title":"Synthesis and evaluation of acridone- and acridone-based anti-herpes agents with topoisomerase activity","volume":"14","author":"Goodell","year":"2006","journal-title":"Bioorg Med Chem"},{"key":"2024103109372437300_cit9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1021\/np060505o","article-title":"Potential cancer chemopreventive in vitro activities of monomeric xanthone derivatives from the marine algicolous fungus","volume":"70","author":"Krick","year":"2007","journal-title":"Monodictys putredinis. 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