{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T14:31:58Z","timestamp":1768487518476,"version":"3.49.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We have examined the possible protective effects of Polygala paniculata extract against methylmercury (MeHg)-induced neurotoxicity in adult mice. MeHg was diluted in drinking water (40 mg L\u22121, freely available) and the hydroalcoholic Polygala extract was diluted in a 150 mm NaCl solution and administered by gavage (100 mg kg\u22121 b.w., twice a day). After a two-week treatment, MeHg exposure significantly inhibited glutathione peroxidase and increased glutathione reductase activity, while the levels of thiobarbituric acid reactive substances were increased in the cerebral cortex and cerebellum. These alterations were prevented by administration of Polygala extract, except for glutathione reductase activity, which remained elevated in the cerebral cortex. Behavioural interference in the MeHg-exposed animals was evident through a marked deficit in the motor performance in the rotarod task, which was completely recovered to control levels by Polygala extract co-administration. This study has shown, for the first time, the in-vivo protective effects of Polygala extract against MeHg-induced neurotoxicity. In addition, our findings encourage studies concerning the beneficial effects of P. paniculata on neurological conditions related to excitotoxicity and oxidative stress.<\/jats:p>","DOI":"10.1211\/jpp.57.11.0017","type":"journal-article","created":{"date-parts":[[2005,10,12]],"date-time":"2005-10-12T21:08:17Z","timestamp":1129151297000},"page":"1503-1508","source":"Crossref","is-referenced-by-count":76,"title":["Protective effects of <i>Polygala paniculata<\/i> extract against methylmercury-induced neurotoxicity in mice"],"prefix":"10.1093","volume":"57","author":[{"given":"Marcelo","family":"Farina","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Santa Catarina , 88040\u2013900, Florian\u00f3polis, SC,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeferson Luis","family":"Franco","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Santa Catarina , 88040\u2013900, Florian\u00f3polis, SC,","place":["Brazil"]},{"name":"Departamento de Ci\u00eancias Fisiol\u00f3gicas, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Santa Catarina , 88040\u2013900, Florian\u00f3polis, SC,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Mafalda","family":"Ribas","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Fisiol\u00f3gicas, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Santa Catarina , 88040\u2013900, Florian\u00f3polis, SC,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via Carla","family":"Meotti","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Fisiol\u00f3gicas, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Santa Catarina , 88040\u2013900, Florian\u00f3polis, SC,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alcir Luiz","family":"Dafr\u00e9","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Fisiol\u00f3gicas, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Santa Catarina , 88040\u2013900, Florian\u00f3polis, SC,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adair R S","family":"Santos","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Fisiol\u00f3gicas, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Santa Catarina , 88040\u2013900, Florian\u00f3polis, SC,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Missau","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Centro de Ci\u00eancias F\u00edsicas e Matem\u00e1ticas, Universidade Federal de Santa Catarina , 88040\u2013900, Florian\u00f3polis, SC,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moacir G","family":"Pizzolatti","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Centro de Ci\u00eancias F\u00edsicas e Matem\u00e1ticas, Universidade Federal de Santa Catarina , 88040\u2013900, Florian\u00f3polis, SC,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,11,1]]},"reference":[{"key":"2024103109414084500_cit1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0197-0186(00)00023-1","article-title":"Methylmercury alters glutamate transport in astrocytes","volume":"37","author":"Aschner","year":"2000","journal-title":"Neurochem. 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