{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:41:57Z","timestamp":1785796917770,"version":"3.56.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study was carried out to evaluate the hepatoprotective activity of glycoprotein isolated from the stems of Ulmus davidiana Nakai (UDN), which has been used as an anti-inflammatory agent in folk medicine. We evaluated lipid peroxidation in glucose\/glucose oxidase (G\/GO)-induced BNL CL.2 cells and measured thiobarbituric acid reactive substances (TBARS), lactate dehydrogenase (LDH), nitric oxide (NO), antioxidant enzyme (superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)), activity of cytotoxic-related signals (hepatic cytochrome c, nuclear factor-kappa B (NF-\u03baB) and activator protein-1 (AP-1)) and levels of plasma lipids (triglyceride (TG) and total cholesterol (TC)) in carbon tetrachloride (CCl4, 1.0 mL kg\u22121)-induced A\/J mouse. The results in G\/GO-induced BNL CL.2 cells showed that UDN glycoprotein had a dose-dependent inhibitory effect on lipid peroxidation. The results in carbon tetrachloride (CCl4, 1.0 mL kg\u22121)-induced A\/J mouse indicated that treatment with UDN glycoprotein (40 mg kg\u22121) lowered LDH activity and TBARS formation, and increased NO production and antioxidant enzymes activity, compared with control. Also, our finding from CCl4-treated mice after pretreatment with UDN glycoprotein demonstrated that the activity of cytotoxic-related signals decreased but the levels of plasma lipids increased, compared with CCl4 treatment alone. Here, we speculate that UDN glycoprotein has a protective character to CCl4-induced mouse liver injury.<\/jats:p>","DOI":"10.1211\/jpp.58.1.0018","type":"journal-article","created":{"date-parts":[[2005,12,19]],"date-time":"2005-12-19T22:06:50Z","timestamp":1135030010000},"page":"143-152","source":"Crossref","is-referenced-by-count":23,"title":["Protective effect of glycoprotein isolated from <i>Ulmus davidiana<\/i> Nakai on carbon tetrachloride-induced mouse liver injury"],"prefix":"10.1093","volume":"58","author":[{"given":"Sei-Jung","family":"Lee","sequence":"first","affiliation":[{"name":"Molecular Biochemistry Laboratory, Institute of Biotechnology, Chonnam National University, Kwangju , 300 Yongbong-Dong, 500\u2013757,","place":["South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil-Sun","family":"Oh","sequence":"additional","affiliation":[{"name":"Molecular Biochemistry Laboratory, Institute of Biotechnology, Chonnam National University, Kwangju , 300 Yongbong-Dong, 500\u2013757,","place":["South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Hyeon","family":"Ko","sequence":"additional","affiliation":[{"name":"Molecular Biochemistry Laboratory, Institute of Biotechnology, Chonnam National University, Kwangju , 300 Yongbong-Dong, 500\u2013757,","place":["South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kye-Taek","family":"Lim","sequence":"additional","affiliation":[{"name":"Molecular Biochemistry Laboratory, Institute of Biotechnology, Chonnam National University, Kwangju , 300 Yongbong-Dong, 500\u2013757,","place":["South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of British Columbia , Vancouver, British Columbia, V6T 1Z3","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,1,1]]},"reference":[{"key":"2024103109335475900_cit1","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.2307\/1383033","article-title":"Guidelines for the capture, handling, and care of mammals as approved by the American Society of Mammalogists","volume":"79","author":"American Society of Mammalogists Animal Care and Use Committee","year":"1998","journal-title":"J. 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