{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:34:13Z","timestamp":1777577653313,"version":"3.51.4"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Oral dosage forms are the preferred means of delivering drugs for systemic absorption. However, development problems occur for drugs with poor water solubility and\/or gastrointestinal permeability. It is generally believed that the in-vivo bioavailability of poorly water-soluble drugs from Class II of the Biopharmaceutics Classification System can be improved by increasing the dissolution rate. We have attempted to increase the in-vivo oral bioavailability of a model Class II drug (griseofulvin) by preparing rapidly-dissolving particles. The solvent-diffusion method was used to prepare particles with hydrophilic surfactants (Brij 76\/Tween 80 surfactant blend) and in-vivo studies were conducted in rats. The griseofulvin particles produced were bipyramidal in habit with a particle size of 2.18 \u00b1 0.12 mm; they contained crystalline drug and a relatively large proportion (12% w\/w) of hydrophilic surfactant. The latter and the small particle size ensured rapid particle dispersion and dissolution in-vitro. Thus, within 30 min of the in-vitro dissolution test, the bipyramidal particles had released \u223c70% of drug compared with \u223c10% from the starting material (particle size 12.61 \u00b1 1.11 \u03bcm). However, the rapid and increased drug dissolution in-vitro was not translated to rapid and enhanced absorption in-vivo, and the oral bioavailability of the model drug was found to be the same from the control and from the bipyramidal particles. The poor in-vivo performance of the bipyramidal particles showed that although the dissolution rate of a Class II drug is thought to be a good indicator of its in-vivo bioavailability, this is not always the case.<\/jats:p>","DOI":"10.1211\/jpp.58.10.0004","type":"journal-article","created":{"date-parts":[[2006,10,9]],"date-time":"2006-10-09T23:02:16Z","timestamp":1160434936000},"page":"1319-1326","source":"Crossref","is-referenced-by-count":8,"title":["Fast-dissolving microparticles fail to show improved oral bioavailability"],"prefix":"10.1093","volume":"58","author":[{"given":"S M","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy , London WC1N 1AX,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I W","family":"Kellaway","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy , London WC1N 1AX,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Murdan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy , London WC1N 1AX,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,10,1]]},"reference":[{"key":"2024103109340123400_cit1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1023\/A:1016212804288","article-title":"A theoretical basis for a biopharmaceutics drug classification: The correlation of in vitro drug product dissolution and in vivo bio-availability","volume":"12","author":"Amidon","year":"1995","journal-title":"Pharm. 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