{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:06:01Z","timestamp":1789743961591,"version":"4.0.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The proportion of the population that is elderly continues to increase, leading to an increasing need to address problems chiefly associated with old age. Progressive ageing of the heart is associated with an increasing incidence of arrhythmias and disorders of the normal origin of the heartbeat, the sinoatrial node. This intrinsic pacemaker of the heart has an increasing tendency with age to lose its dominant role in pacing the heart, and regulation of heart rate becomes erratic. This \u2018sick sinus syndrome\u2019 is associated with fainting, palpitations, shortness of breath and sudden death. Current treatment of this condition is by implantation of an artificial pacemaker, an intervention increasingly required with age. The current evidence suggests that the normal heartbeat fails due to changes in the expression of critical proteins that ensure the correct production and conduction of the cardiac action potential. Depletion of a protein directly responsible for providing electrical connections between the cells of the heart, connexin 43, appears to leave the normal cardiac pacemaker disconnected and unable to drive the heart. This process may be associated with age-dependent changes in stress-related signalling. Simple interventions such as exercise could impact on the processes hypothesized to be involved and may offer a means to preserve the stability of the electrical activity of the heart into old age without pharmacological manipulation.<\/jats:p>","DOI":"10.1211\/jpp.58.12.0002","type":"journal-article","created":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T23:24:27Z","timestamp":1166657067000},"page":"1571-1576","source":"Crossref","is-referenced-by-count":29,"title":["Ageing to arrhythmias: conundrums of connections in the ageing heart"],"prefix":"10.1093","volume":"58","author":[{"given":"Sandra A","family":"Jones","sequence":"first","affiliation":[{"name":"Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds , Leeds LS2 9JT,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,12,1]]},"reference":[{"key":"2024103109345879800_cit1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1006\/jmcc.1998.0862","article-title":"Age-related decrease in cardiac tolerance to oxidative stress","volume":"31","author":"Abete","year":"1999","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2024103109345879800_cit2","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1093\/emboj\/18.5.1321","article-title":"Regulation of JNK signalling by GSTp","volume":"18","author":"Adler","year":"1999","journal-title":"EMBO J."},{"key":"2024103109345879800_cit3","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1093\/eurheartj\/14.9.1278","article-title":"Electrophysiology of the ageing rabbit and cat sinoatrial node \u2014 a comparative study","volume":"14","author":"Alings","year":"1993","journal-title":"Eur. Heart J."},{"key":"2024103109345879800_cit4","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1161\/01.CIR.103.5.769","article-title":"Pathophysiology and prevention of atrial fibrillation","volume":"103","author":"Allessie","year":"2001","journal-title":"Circulation"},{"key":"2024103109345879800_cit5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cardiores.2004.10.033","article-title":"Age-associated changes in electrophysiologic remodelling: a potential contributor to initiation of atrial fibrillation","volume":"66","author":"Anyukhovsky","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"2024103109345879800_cit6","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1161\/01.RES.83.6.629","article-title":"Rapid turnover of connexin43 in the adult rat heart","volume":"83","author":"Beardslee","year":"1998","journal-title":"Circ. 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Soc."},{"key":"2024103109345879800_cit15","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.0954-6820.1975.tb19555.x","article-title":"Treatment of sinoatrial syndrome with permanent cardiac pacing in 90 patients","volume":"198","author":"Hartel","year":"1975","journal-title":"Acta Med. Scand."},{"key":"2024103109345879800_cit16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1006\/meth.1999.0931","article-title":"Use of antibodies in the analysis of connexin43 turnover and phosphorylation","volume":"20","author":"Hertzberg","year":"2000","journal-title":"Methods"},{"key":"2024103109345879800_cit17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0008-6363(01)00421-7","article-title":"Heterogeneous expression of connexins in rabbit sinoatrial node cells: correlation between connexin isotype and cell size","volume":"53","author":"Honjo","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"2024103109345879800_cit18","doi-asserted-by":"crossref","first-page":"H1696","DOI":"10.1152\/ajpheart.00761.2003","article-title":"Exercise training improves cardiac function-related gene levels through thyroid hormone receptor signaling in aged rats","volume":"286","author":"Iemitsu","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2024103109345879800_cit19","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1126\/science.1072682","article-title":"Mitogen-activated protein kinase pathways mediated by ERK, JNK and p38 protein kinases","volume":"298","author":"Johnson","year":"2002","journal-title":"Science"},{"key":"2024103109345879800_cit20","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1113\/jphysiol.2004.072108","article-title":"Ageing related changes of connexins and conduction within the sinoatrial node","volume":"560","author":"Jones","year":"2004","journal-title":"J. Physiol. (London)"},{"key":"2024103109345879800_cit21","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1161\/01.RES.86.12.1193","article-title":"Gap junctions in cardiovascular disease","volume":"86","author":"Jongsma","year":"2000","journal-title":"Circ. Res."},{"key":"2024103109345879800_cit22","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/cvr\/4.2.160","article-title":"The normal range and determinants of the intrinsic heart rate in man","volume":"4","author":"Jose","year":"1970","journal-title":"Cardiovasc. Res."},{"key":"2024103109345879800_cit23","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0002-8703(83)90208-9","article-title":"Coronary heart disease and atrial fibrillation: The Framingham study","volume":"106","author":"Kannel","year":"1983","journal-title":"Am. Heart J."},{"key":"2024103109345879800_cit24","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0008-6363(02)00273-0","article-title":"Structural correlate of atrial fibrillation in human patients","volume":"54","author":"Kostin","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"2024103109345879800_cit25","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1046\/j.1444-2892.2002.00126.x","article-title":"Cardiovascular ageing in health sets the stage for cardiovascular disease","volume":"11","author":"Lakatta","year":"2002","journal-title":"Heart, Lung and Circulation"},{"key":"2024103109345879800_cit26","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/S0002-9149(02)03403-3","article-title":"Comparison of expression of connexin in right atrial myocardium in patients with chronic atrial fibrillation versus those in sinus rhythm","volume":"91","author":"Nao","year":"2003","journal-title":"Am. J Cardiol."},{"key":"2024103109345879800_cit27","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1161\/01.RES.0000059304.97120.2F","article-title":"Cx43 and dual-pathway electrophysiology of the atrioventricular node and atrioventricular nodal re-entry","volume":"92","author":"Nikolski","year":"2003","journal-title":"Circ. Res."},{"key":"2024103109345879800_cit28","first-page":"H1795","article-title":"Diminished heat shock protein 70 mRNA induction in ages rat hearts after ischemia","volume":"267","author":"Nitta","year":"1994","journal-title":"Am. J. Physiol."},{"key":"2024103109345879800_cit29","first-page":"85","article-title":"Distribution of the cardiac gap junction protein, connexin43 in the neonatal and adult human heart","volume-title":"Muscle and Motility: Proceedings of XIXth European Conference","author":"Oosthoek","year":"1990"},{"key":"2024103109345879800_cit30","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/BF02125744","article-title":"The mammalian sinoatrial node","volume":"1","author":"Opthof","year":"1988","journal-title":"Cardiovasc. Drugs"},{"key":"2024103109345879800_cit31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0008-6363(99)00322-3","article-title":"The normal range and determinants of the intrinsic heart rate in man","volume":"45","author":"Opthof","year":"2000","journal-title":"Cardiovasc. 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Chem."},{"key":"2024103109345879800_cit35","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1161\/01.CIR.96.7.2455","article-title":"Incidence of and risk factors for atrial fibrillation in older adults","volume":"96","author":"Psaty","year":"1997","journal-title":"Circulation"},{"key":"2024103109345879800_cit36","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/BF02172188","article-title":"A new puffing pattern induced by a temperature shock and DNP in Drosophila","volume":"18","author":"Ritossa","year":"1962","journal-title":"Experientia"},{"key":"2024103109345879800_cit37","first-page":"26","article-title":"Update on sick sinus syndrome, a cardiac disorder of aging","volume":"45","author":"Rodriguez","year":"1990","journal-title":"Geriatrics"},{"key":"2024103109345879800_cit38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/ageing\/29.1.13","article-title":"Pacemaker syndrome in older people","volume":"29","author":"Ross","year":"2000","journal-title":"Age Ageing"},{"key":"2024103109345879800_cit39","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1161\/01.CIR.46.1.5","article-title":"Clinical spectrum of the sick sinus syndrome","volume":"46","author":"Rubenstein","year":"1972","journal-title":"Circulation"},{"key":"2024103109345879800_cit40","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1161\/01.RES.86.7.723","article-title":"Connexin expression and turnover: implications for cardiac excitability","volume":"86","author":"Saffitz","year":"2000","journal-title":"Circ. Res."},{"key":"2024103109345879800_cit41","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1536\/jhj.44.385","article-title":"Age-related changes in the electrophysiologic properties of the atrium in patients with no history of atrial fibrillation","volume":"44","author":"Sakabe","year":"2003","journal-title":"Jpn Heart J."},{"key":"2024103109345879800_cit42","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1152\/physrev.2001.81.4.1461","article-title":"Heat shock proteins and cardiovascular physiology","volume":"81","author":"Snoeckx","year":"2001","journal-title":"Physiol. Rev."},{"key":"2024103109345879800_cit43","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0379-0738(99)00103-6","article-title":"Age-related variation in the interstitial tissues of the cardiac conduction system; and autopsy study of 230 Han Chinese","volume":"104","author":"Song","year":"1999","journal-title":"Forensic Sci. Int."},{"key":"2024103109345879800_cit44","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1161\/01.CIR.90.2.1103","article-title":"Changes in the topology of gap junctions as an adaptive structural response of the myocardium","volume":"90","author":"Spach","year":"1994","journal-title":"Circulation"},{"key":"2024103109345879800_cit45","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1172\/JCI119327","article-title":"In vivo gene transfection with heat shock protein 70 enhances myocardial tolerance to ischemia-reperfusion injury in rat","volume":"99","author":"Suzuki","year":"1997","journal-title":"J. Clin. Invest."},{"key":"2024103109345879800_cit46","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s003950070039","article-title":"Reduction in myocardial apoptosis associated with overexpression of heat shock protein 70","volume":"95","author":"Suzuki","year":"2000","journal-title":"Basic Res. 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