{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:50:32Z","timestamp":1791157832947,"version":"4.1.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We have previously verified that niga-ichigoside F1 (NI), a triterpene isolated from Rubus imperialis, exhibits significant and potent antinociceptive action when evaluated in some pharmacological models of pain in mice. This effect was confirmed in other experimental models and also the mechanism of action has been evaluated. The antinociception caused by NI (60 mg kg\u22121) in both phases of the formalin test was significantly attenuated by intraperitoneal injection of mice with haloperidol (a dopaminergic antagonist, 0.20 mg kg\u22121) and L-arginine (precursor of nitric oxide, 600 mg kg\u22121). Regarding the cholinergic system, atropine (a cholinergic antagonist 60 mg kg\u22121) reverted only the second phase. The effect of NI was not affected by treatment of mice with yohimbine (an alpha2-adrenoceptor antagonist, 0.15 mg kg\u22121). The same pharmacological profile was observed for the administration of naloxone (an opioid receptor antagonist, 1 mg kg\u22121). On the other hand, intraperitoneal injection caused dose-related and significant effects against glutamate- and capsaicin-induced pain, respectively. In conclusion, the marked antinociception of NI appears to be related to the dopaminergic, cholinergic, glutamatergic, tachykininergic and oxinitrergic systems, supporting the ethnomedical use of Rubus imperialis (Rosaceae).<\/jats:p>","DOI":"10.1211\/jpp.58.12.0015","type":"journal-article","created":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T18:24:27Z","timestamp":1166639067000},"page":"1669-1675","source":"Crossref","is-referenced-by-count":15,"title":["Analysis of the mechanism of antinociceptive action of niga-ichigoside F1 obtained from\n                    <i>Rubus imperialis<\/i>\n                    (Rosaceae)"],"prefix":"10.1093","volume":"58","author":[{"given":"Juliana Vargas","family":"Ardenghi","sequence":"first","affiliation":[{"name":"Programa de Mestrado em Ci\u00eancias Farmac\u00eauticas e N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR)\/CCS, Universidade do Vale do Itaja\u00ed (UNIVALI) , 88302-202, Itaja\u00ed-SC,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia","family":"Kanegusuku","sequence":"additional","affiliation":[{"name":"Programa de Mestrado em Ci\u00eancias Farmac\u00eauticas e N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR)\/CCS, Universidade do Vale do Itaja\u00ed (UNIVALI) , 88302-202, Itaja\u00ed-SC,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rivaldo","family":"Niero","sequence":"additional","affiliation":[{"name":"Programa de Mestrado em Ci\u00eancias Farmac\u00eauticas e N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR)\/CCS, Universidade do Vale do Itaja\u00ed (UNIVALI) , 88302-202, Itaja\u00ed-SC,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdir Cechinel","family":"Filho","sequence":"additional","affiliation":[{"name":"Programa de Mestrado em Ci\u00eancias Farmac\u00eauticas e N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR)\/CCS, Universidade do Vale do Itaja\u00ed (UNIVALI) , 88302-202, Itaja\u00ed-SC,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco Delle","family":"Monache","sequence":"additional","affiliation":[{"name":"Dipartimento Chimica e Tecnologia delle Sostanze Biologicamente Attive, Universit\u00e0 di Roma , P.le A. Moro 5, 00185 Roma,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosendo Augusto","family":"Yunes","sequence":"additional","affiliation":[{"name":"Curso de P\u00f3s Gradua\u00e7\u00e3o em Qu\u00edmica, Universidade Federal de Santa Catarina (UFSC) , 88040-900, Florian\u00f3polis-SC,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia Maria","family":"De Souza","sequence":"additional","affiliation":[{"name":"Programa de Mestrado em Ci\u00eancias Farmac\u00eauticas e N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR)\/CCS, Universidade do Vale do Itaja\u00ed (UNIVALI) , 88302-202, Itaja\u00ed-SC,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,12,1]]},"reference":[{"key":"2024103109345641800_cit1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0006-8993(01)03240-1","article-title":"Mechanism underlying the nociception and paw edema caused by injection of glutamate into the mouse paw","volume":"924","author":"Beirith","year":"2002","journal-title":"Brain Res."},{"key":"2024103109345641800_cit2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0006-8993(01)03126-2","article-title":"Antinociceptive profiles of aspirin and acetaminophen in formalin, substance P and glutamate pain models","volume":"7","author":"Choi","year":"2001","journal-title":"Brain Res."},{"key":"2024103109345641800_cit3","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1248\/bpb.26.1436","article-title":"Antinociceptive and antiinflammatory effects of Niga-ichigoside F1 and 23-hydroxytormentic acid obtained from Rubus coreanus","volume":"26","author":"Choi","year":"2003","journal-title":"Biol. 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