{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:42:58Z","timestamp":1775022178368,"version":"3.50.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Royal jelly (RJ) has various pharmacological actions, including hypolipidaemic, hypocholesterolaemic and anti-atherosclerotic effects, in experimental animals but the molecular mechanisms involved remain unclear. Here, we investigated changes in the expression of lipid metabolism-associated genes in the liver of RJ-treated mice by means of a DNA microarray technique to obtain clues to the mechanism of the hypocholesterolaemic action of RJ. We compared the hepatic gene expression profiles in three groups of mice fed a diet containing 5% RJ, a diet containing 5% RJ stored at 40\u00b0C for 7 days (40-7d RJ) or a control diet which provided the same total energy as the other diets. RJ decreased gene expression of squalene epoxidase (SQLE), which is a key enzyme in cholesterol biosynthesis, and sterol regulatory element-binding protein (SREB)-1, which may be a transcriptional factor of SQLE. It increased gene expression of low-density lipoprotein receptor (LDLR), which is involved in cholesterol incorporation in liver. Thus, the hypocholesterolaemic action of RJ appears to be associated with a decrease of SQLE and an increase of LDLR in mice.<\/jats:p>","DOI":"10.1211\/jpp.58.12.0017","type":"journal-article","created":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T23:24:27Z","timestamp":1166657067000},"page":"1683-1689","source":"Crossref","is-referenced-by-count":40,"title":["Changes in hepatic gene expression associated with the hypocholesterolaemic activity of royal jelly"],"prefix":"10.1093","volume":"58","author":[{"given":"Masaki","family":"Kamakura","sequence":"first","affiliation":[{"name":"Biotechnology Research Center, Faculty of Engineering, Toyama Prefectural University , 5180 Kurokawa, Imizu, Toyama 939-0398,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Moriyama","sequence":"additional","affiliation":[{"name":"Department of Applied Life Chemistry, Graduate School of Agriculture, Kinki University , Nara 631-0052,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Sakaki","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Faculty of Engineering, Toyama Prefectural University , 5180 Kurokawa, Imizu, Toyama 939-0398,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,12,1]]},"reference":[{"key":"2024103109350817600_cit1","first-page":"137","article-title":"Regression of atherosclerosis","volume":"1","author":"Armstrong","year":"1976","journal-title":"Atheroscl. 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