{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:43:33Z","timestamp":1791636213849,"version":"4.3.4"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In this study we developed emulsomes, a novel lipoidal vesicular system with an internal solid fat core surrounded by a phospholipid bilayer. Plain emulsomal formulations composed of solid lipid (trilaurin or tristearin), cholesterol and soya phosphatidylcholine and stearylamine containing cationic emulsomes loaded with an antiviral drug (zidovudine) were prepared by a simple cast film method followed by sonication to produce emulsomes of nanometric size range. All different types of formulations were optimized for lipid ratios and characterized in-vitro for shape, morphology, size and in-vitro drug release profile. Emulsomal formulations displayed a sufficiently slow drug release profile (12\u201315% after 24 h). In-vivo organ distribution studies in rats demonstrated better uptake of emulsomal formulations by the liver cells. Further, a significantly higher (P &amp;lt; 0.05) liver concentration of drug was estimated over a period of 24 h for cationic emulsomes than for plain neutral emulsomes. We concluded that cationic emulsomes could fuse with the endosomal membrane due to charge-charge interaction and were released in the cytoplasm before lysosomal degradation and could sustain drug release over a prolonged period. The proposed cationic emulsome-based system showed excellent potential for intracellular hepatic targeting and the strategy could play a vital role in the effective treatment of life-threatening viral infections, such as hepatitis, HIV and Epstein-Barr virus infection.<\/jats:p>","DOI":"10.1211\/jpp.58.3.0005","type":"journal-article","created":{"date-parts":[[2006,2,23]],"date-time":"2006-02-23T21:35:32Z","timestamp":1140730532000},"page":"321-326","source":"Crossref","is-referenced-by-count":81,"title":["Development and characterization of emulsomes for sustained and targeted delivery of an antiviral agent to liver"],"prefix":"10.1093","volume":"58","author":[{"given":"S P","family":"Vyas","sequence":"first","affiliation":[{"name":"Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour University , Sagar (M.P.), 470003","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasika","family":"Subhedar","sequence":"additional","affiliation":[{"name":"Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour University , Sagar (M.P.), 470003","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanyog","family":"Jain","sequence":"additional","affiliation":[{"name":"Division of Radiopharmaceuticals, Nano Tech and Stem Cell Research, Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organization , Brig. 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