{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T03:28:44Z","timestamp":1786418924840,"version":"build-2736575974"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vimang is the brand name of formulations containing an extract of Mangifera indica L., ethnopharmacologically used in Cuba for the treatment of some immunopathological disorders, including bronchial asthma, atopic dermatitis and other allergic diseases. However, the effects of Vimang on allergic response have not been reported until now. In this study, the effects of Vimang and mangiferin, a C-glucosylxanthone isolated from the extract, on different parameters of allergic response are reported. Vimang and mangiferin showed a significant dose-dependent inhibition of IgE production in mice and anaphylaxis reaction in rats, histamine-induced vascular permeability and the histamine release induced by compound 48\/80 from rat mast cells, and of lymphocyte proliferative response as evidence of the reduction of the amount of B and T lymphocytes able to contribute to allergic response. In these experiments, ketotifen, promethazine and disodium cromoglicate were used as reference drugs. Furthermore, we demonstrated that Vimang had an effect on an in-vivo model of inflammatory allergy mediated by mast cells. These results constitute the first report of the anti-allergic properties of Vimang on allergic models, as well as suggesting that this natural extract could be successfully used in the treatment of allergic disorders. Mangiferin, the major compound of Vimang, contributes to the anti-allergic effects of the extract.<\/jats:p>","DOI":"10.1211\/jpp.58.3.0014","type":"journal-article","created":{"date-parts":[[2006,2,23]],"date-time":"2006-02-23T21:35:32Z","timestamp":1140730532000},"page":"385-392","source":"Crossref","is-referenced-by-count":70,"title":["Anti-allergic properties of<i>Mangifera indica<\/i>L. extract (Vimang) and contribution of its glucosylxanthone mangiferin"],"prefix":"10.1093","volume":"58","author":[{"given":"Dagmar Garc\u00eda","family":"Rivera","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology, Department of Biomedical Research, Center of Pharmaceutical Chemistry , P. O. Box 16042, Havana,","place":["Cuba"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivones Hern\u00e1ndez","family":"Balmaseda","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Department of Biomedical Research, Center of Pharmaceutical Chemistry , P. O. Box 16042, Havana,","place":["Cuba"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina \u00c1lvarez","family":"Le\u00f3n","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Department of Biomedical Research, Center of Pharmaceutical Chemistry , P. O. Box 16042, Havana,","place":["Cuba"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belkis Cancio","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Department of Biomedical Research, Center of Pharmaceutical Chemistry , P. O. Box 16042, Havana,","place":["Cuba"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda M\u00e1rquez","family":"Montiel","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Department of Biomedical Research, Center of Pharmaceutical Chemistry , P. O. Box 16042, Havana,","place":["Cuba"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabino Garrido","family":"Garrido","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Department of Biomedical Research, Center of Pharmaceutical Chemistry , P. O. Box 16042, Havana,","place":["Cuba"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 Delgado","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Department of Biomedical Research, Center of Pharmaceutical Chemistry , P. O. Box 16042, Havana,","place":["Cuba"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Cuzzocrea","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina , Torre Biologica, Policlinico Universitario, 98123 Messina,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,3,1]]},"reference":[{"key":"2024103109333271500_cit1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1254\/jjp.66.87","article-title":"Antiallergic effect of ZRC-2060: antihistaminic action","volume":"66","author":"Abe","year":"1994","journal-title":"Jpn. J. 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