{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T04:10:13Z","timestamp":1730434213333,"version":"3.28.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Bovine tuberculosis caused by Mycobacterium bovis remains an economically important problem in Great Britain with potential zoonotic consequences, and the incidence is rising exponentially. In 1997 an independent scientific review recommended that the best option for disease control in Great Britain was the development of a cattle vaccine. Bovine tuberculosis remains a significant problem in countries of the developing world. Indeed, more than 94% of the world's population live in countries in which the control of bovine tuberculosis in buffalos or cattle is limited or absent. Effective vaccination strategies would have a major impact in countries that cannot afford expensive test and slaughter-based control strategies. Here, we present a review of progress toward that goal, and discuss how this progress has shaped our research strategy for the development of a vaccine.<\/jats:p>","DOI":"10.1211\/jpp.58.6.0005","type":"journal-article","created":{"date-parts":[[2006,5,20]],"date-time":"2006-05-20T17:22:36Z","timestamp":1148145756000},"page":"749-757","source":"Crossref","is-referenced-by-count":16,"title":["Development of vaccines against bovine tuberculosis"],"prefix":"10.1093","volume":"58","author":[{"given":"P J","family":"Hogarth","sequence":"first","affiliation":[{"name":"TB Research Group, Veterinary Laboratories Agency-Weybridge , New Haw, Addlestone, Surrey,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R G","family":"Hewinson","sequence":"additional","affiliation":[{"name":"TB Research Group, Veterinary Laboratories Agency-Weybridge , New Haw, Addlestone, Surrey,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H M","family":"Vordermeier","sequence":"additional","affiliation":[{"name":"TB Research Group, Veterinary Laboratories Agency-Weybridge , New Haw, Addlestone, Surrey,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,6,1]]},"reference":[{"key":"2024103109350555100_cit1","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1128\/JCM.41.8.3719-3728.2003","article-title":"Genomic approach to identification of Mycobacterium bovis diagnostic antigens in cattle","volume":"41","author":"Aagaard","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"2024103109350555100_cit2","doi-asserted-by":"crossref","DOI":"10.1128\/9781555818357","article-title":"The BCG experience: implications for future vaccines against tuberculosis","volume-title":"Tuberculosis: pathogenesis, protection and control","author":"Bloom","year":"1994"},{"key":"2024103109350555100_cit3","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1128\/IAI.66.10.5048-5051.1998","article-title":"Effective, nonsensitizing vaccination with culture filtrate proteins against virulent Mycobacterium bovis infections in mice","volume":"66","author":"Bosio","year":"1998","journal-title":"Infect. 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Biol."},{"volume-title":"Bovine tuberculosis","year":"1947","author":"Francis","key":"2024103109350555100_cit16"},{"volume-title":"A study of tuberculosis in animals and man","year":"1958","author":"Francis","key":"2024103109350555100_cit17"},{"key":"2024103109350555100_cit18","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1128\/IAI.68.5.2948-2953.2000","article-title":"CpG oligodeoxynucleotides and interleukin-12 improve the efficacy of Mycobacterium bovis BCG vaccination in mice challenged with","volume":"68","author":"Freidag","year":"2000","journal-title":"M. tuberculosis. Infect. Immun."},{"key":"2024103109350555100_cit19","doi-asserted-by":"crossref","first-page":"7877","DOI":"10.1073\/pnas.1130426100","article-title":"The complete genome sequence of Mycobacterium bovis","volume":"100","author":"Garnier","year":"2003","journal-title":"Proc. Natl. Acad. 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Clin. Exp. Immunol."},{"key":"2024103109350555100_cit29","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1128\/IAI.71.4.1672-1679.2003","article-title":"A new vaccine against tuberculosis affords greater survival after challenge than the current vaccine in the guinea pig model of pulmonary tuberculosis","volume":"71","author":"Horwitz","year":"2003","journal-title":"Infect. Immun."},{"key":"2024103109350555100_cit30","doi-asserted-by":"crossref","first-page":"13853","DOI":"10.1073\/pnas.250480397","article-title":"Recombinant bacillus calmette-guerin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model","volume":"97","author":"Horwitz","year":"2000","journal-title":"Proc. Natl. Acad. 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Immunopathol."},{"key":"2024103109350555100_cit41","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1016\/S0264-410X(02)00216-5","article-title":"CpG-containing oligodeoxynucleotides augment and switch the immune responses of cattle to bovine herpesvirus-1 glycoprotein D","volume":"20","author":"Rankin","year":"2002","journal-title":"Vaccine"},{"key":"2024103109350555100_cit42","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/nm1009","article-title":"A CD4(+) T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease","volume":"10","author":"Reece","year":"2004","journal-title":"Nat. Med."},{"key":"2024103109350555100_cit43","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1472-9792(02)00080-X","article-title":"Prospects for a better vaccine against tuberculosis","volume":"83","author":"Reed","year":"2003","journal-title":"Tuberculosis (Edinb)"},{"year":"2006","author":"Sanger Institute","key":"2024103109350555100_cit44"},{"key":"2024103109350555100_cit45","doi-asserted-by":"crossref","first-page":"7618","DOI":"10.4049\/jimmunol.172.12.7618","article-title":"Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant protein","volume":"172","author":"Skeiky","year":"2004","journal-title":"J. Immunol."},{"key":"2024103109350555100_cit46","first-page":"112","article-title":"Vaccination of animals against","volume":"20","author":"Skinner","year":"2001","journal-title":"Mycobacterium bovis. Rev. Sci. 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Immunopathol."},{"key":"2024103109350555100_cit55","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S1472-9792(03)00055-6","article-title":"Vaccination with DNA vaccines encoding MPB70 or MPB83 or a MPB70 DNA prime-protein boost does not protect cattle against bovine tuberculosis","volume":"83","author":"Wedlock","year":"2003","journal-title":"Tuberculosis (Edinb)"},{"key":"2024103109350555100_cit56","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.vetimm.2005.01.002","article-title":"Vaccination of cattle with Mycobacterium bovis culture filtrate proteins and CpG oligodeoxynucleotides induces protection against bovine tuberculosis","volume":"106","author":"Wedlock","year":"2005","journal-title":"Vet. Immunol. 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