{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:30:16Z","timestamp":1767375016229,"version":"3.28.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Lannea microcarpa (Anacardiaceae) is a tropical tree used in African folk medicine and commercial dermopharmaceutical formulations. Fractionation and analysis of its polar extract allowed the identification of 4\u2032-methoxy-myricetin 3-O-\u03b1-l-rhamnopyranoside, myricetin 3-O-\u03b1-l-rhamnopyranoside, myricetin 3-O-\u03b2-d-glucopyranoside, vitexin, isovitexin, gallic acid and epi-catechin, as the major constituents. In-vivo assay (the croton oil ear test in mice) showed that the extract had significant anti-inflammatory effect (ID50 = 900 \u03bcg cm2) but ten times lower than that of indometacin (ID50 = 93 \u03bcg cm2), the non-steroidal anti-inflammatory drug used as reference. Cytotoxicity and cutaneous irritation of the extract and its constituents were investigated. The crude extract and its major components did not affect cell viability in-vitro either in three different cultures (J774.A1, WEHI-164 and HEK-293) of cells grown in monolayers or in the reconstituted human epidermis (RHE, 3D model), nor did they cause release of pro-inflammatory mediators (IL-1\u03b1) or histomorphological modification of RHE.<\/jats:p>","DOI":"10.1211\/jpp.58.7.0014","type":"journal-article","created":{"date-parts":[[2006,6,17]],"date-time":"2006-06-17T17:51:22Z","timestamp":1150566682000},"page":"981-988","source":"Crossref","is-referenced-by-count":21,"title":["An extract of <i>Lannea microcarpa<\/i>: composition, activity and evaluation of cutaneous irritation in cell cultures and reconstituted human epidermis"],"prefix":"10.1093","volume":"58","author":[{"given":"P","family":"Picerno","sequence":"first","affiliation":[{"name":"School of Pharmacy and Master in Cosmetic Science and Technology, University of Salerno ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Mencherini","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Master in Cosmetic Science and Technology, University of Salerno ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R Delia","family":"Loggia","sequence":"additional","affiliation":[{"name":"Dipartimento di Economia e Merceologia, University of Trieste ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Meloni","sequence":"additional","affiliation":[{"name":"VitroScreen Srl , Piazza Giulio Cesare 17, 20145, Milano,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Sanogo","sequence":"additional","affiliation":[{"name":"Faculte de Medicine, Farmacie et D'Odontostomatologie, University of Bamako ,","place":["Mali"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R P","family":"Aquino","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Master in Cosmetic Science and Technology, University of Salerno ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,7,1]]},"reference":[{"key":"2024103109345248600_cit1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0031-9422(00)81534-4","article-title":"Studies of uronic acid materials. 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