{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:24:29Z","timestamp":1790918669198,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ivermectin (IVM), a macrocyclic lactone used as antiparasite agent, has been reported as a P-glycoprotein (P-gp) substrate. The participation of P-gp in the IVM excretion process has been previously demonstrated. Sex-related differences in the kinetic behaviour of some macrocyclic lactone compounds have been observed. The aim of this work was to characterize in-vivo the comparative gastrointestinal disposition of IVM in male and female rats. The sex-related influence on the itraconazole (ITZ) modulation of P-gp-mediated IVM intestinal transport was also assessed. Sixty Wistar rats (30 male, 30 female) received IVM alone or co-administered with ITZ. Rats were killed between 6 and 72h after treatment and blood, gastrointestinal tissues and lumen contents were collected. IVM concentrations were determined by high performance liquid chromatography. Substantial sex-related differences in the IVM disposition kinetics were observed. Higher IVM systemic availability was observed in female rats. The ITZ-mediated modulation of the IVM disposition kinetics had a differential impact between male and female rats. Co-administration with ITZ resulted in a marked increase in the IVM concentrations in the wall tissue from different portions of the gastrointestinal tract of male rats. The presence of ITZ induced drastic sex-related changes on the P-gp-mediated IVM gastrointestinal disposition.<\/jats:p>","DOI":"10.1211\/jpp.58.8.0005","type":"journal-article","created":{"date-parts":[[2006,7,23]],"date-time":"2006-07-23T23:46:55Z","timestamp":1153698415000},"page":"1055-1062","source":"Crossref","is-referenced-by-count":17,"title":["Sex-related differences in the gastrointestinal disposition of ivermectin in the rat: P-glycoprotein involvement and itraconazole modulation"],"prefix":"10.1093","volume":"58","author":[{"given":"A","family":"Lifschitz","sequence":"first","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda, Departamento de Fisiopatolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro , Tandil,","place":["Argentina"]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) , ( )","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ballent","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda, Departamento de Fisiopatolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro , Tandil,","place":["Argentina"]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) , ( )","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Virkel","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda, Departamento de Fisiopatolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro , Tandil,","place":["Argentina"]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) , ( )","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Sallovitz","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda, Departamento de Fisiopatolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro , Tandil,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Lanusse","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda, Departamento de Fisiopatolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro , Tandil,","place":["Argentina"]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) , ( )","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,8,1]]},"reference":[{"key":"2024103109344996200_cit1","first-page":"417","article-title":"Ivermectin in goat milk after subcutaneous injection","volume":"24","author":"Alvinerie","year":"1993","journal-title":"Vet. 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