{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T04:09:38Z","timestamp":1730434178553,"version":"3.28.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The aim of this study was to examine the effect of fexofenadine hydrochloride (FEX), a histamine H1- receptor antagonist, on nitric oxide (NO) production in-vitro and in-vivo. Nasal fibroblasts (5 \u00d7 105 cells per mL) were stimulated with 25 ng mL\u22121 tumour necrosis factor-\u03b1 in the presence of various concentrations of FEX. NO levels in 24-h-culture supernatants were measured by the Griess method and levels of inducible nitric oxide synthase (iNOS) mRNA levels in 12-h-cultured cells were measured by ELISA. FEX at more than 0.5 \u03bcg mL\u22121 suppressed NO production from fibroblasts by inhibiting expression of iNOS mRNA. We also examined whether FEX could suppress NO production induced by lipopolysaccharide (LPS) stimulation in-vivo. BALB\/c mice were treated with 5.0 mg kg\u22121 LPS i.p. after daily oral doses of FEX, 1.0 mg kg\u22121, for 1\u20133 weeks. Plasma was obtained 6 h later and NO levels measured by the Griess method. Expression of iNOS mRNA in lung tissues was measured by ELISA 6h after LPS injection. Oral administration of FEX for 2 and 3 weeks, but not 1 week, significantly suppressed NO levels in plasma through the inhibition of iNOS mRNA expression, which were enhanced by LPS stimulation. These results suggest that the attenuating effect of FEX on NO production may be of therapeutic benefit in allergic diseases.<\/jats:p>","DOI":"10.1211\/jpp.59.10.0009","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T00:43:58Z","timestamp":1190940238000},"page":"1389-1395","source":"Crossref","is-referenced-by-count":4,"title":["Suppressive activity of fexofenadine hydrochloride on nitric oxide production in-vitro and in-vivo"],"prefix":"10.1093","volume":"59","author":[{"given":"Kazuhito","family":"Asano","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Medicine, Showa University , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-ichi","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, School of Medicine, Showa University , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, School of Medicine, Showa University , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Furuya","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, School of Medicine, Showa University , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harumi","family":"Suzaki","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, School of Medicine, Showa University , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Hisamitsu","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Showa University , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,10,1]]},"reference":[{"key":"2024103109355054500_cit1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/sj.bjp.0706207","article-title":"Protein kinase C alpha mediates TNF release process in RBL-2H3 mast cells","volume":"145","author":"Abdel-Raheem","year":"2005","journal-title":"Br. 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