{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:55:31Z","timestamp":1768474531053,"version":"3.49.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The possible gastroprotective effects of the hydroalcoholic extract of Polygala paniculata in rats have been evaluated. We have investigated the effects of this hydroalcoholic extract on acute lesions induced by ethanol (70%, p.o.) and indometacin (20 mg kg\u22121, s.c). Its influence on mucus secretion was investigated, measured as the amount of Alcian blue dye estimated by colorimetry, and antisecretory effects were assessed in the pylorus ligature model. The treatment of rats with a crude hydroalcoholic extract of P. paniculata (HEPP; 30, 100, 300 mg kg\u22121, p.o., or 3, 10 and 30 mg kg\u22121, i.p.) decreased the ulcer index, and maintained the gastric mucus production in acute gastric lesions caused by ethanol 70%. In addition, the extract partially protected the mucosa against indometacin-induced lesions. The extract did not change the volume and acidity of gastric secretion in the pylorus-ligated rat. An additional antioxidant activity of the extract and its isolated flavonoid compound rutin, in the DPPH free radical scavenging assay, was observed. In conclusion, HEPP exhibited marked gastroprotection; these effects may have involved prostaglandins and be related to cytoprotective factors, such as antioxidant activity and maintenance of mucus production.<\/jats:p>","DOI":"10.1211\/jpp.59.10.0012","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T00:43:58Z","timestamp":1190940238000},"page":"1413-1419","source":"Crossref","is-referenced-by-count":24,"title":["Gastroprotective activity of the hydroalcoholic extract obtained from<i>Polygala paniculate<\/i>L. in rats"],"prefix":"10.1093","volume":"59","author":[{"given":"Fernanda da Rocha","family":"Lapa","sequence":"first","affiliation":[{"name":"Departamento de Farmacologia, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Paran\u00e1 , Curitiba, 88015-420, PR,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Setim","family":"Freitas","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Paran\u00e1 , Curitiba, 88015-420, PR,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane Hatsuko","family":"Baggio","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Paran\u00e1 , Curitiba, 88015-420, PR,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana Cristina","family":"Missau","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal de Santa Catarina, Campus Universit\u00e1rio , Trindade, Florian\u00f3polis, 88040-900, SC,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moacir Geraldo","family":"Pizzolatti","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal de Santa Catarina, Campus Universit\u00e1rio , Trindade, Florian\u00f3polis, 88040-900, SC,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adair R S","family":"Santos","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Fisiol\u00f3gicas, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Santa Catarina, Campus Universit\u00e1rio , Trindade, Florian\u00f3polis, 88040-900, SC,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Consuelo A","family":"Marques","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Paran\u00e1 , Curitiba, 88015-420, PR,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,10,1]]},"reference":[{"key":"2024103109352232900_cit1","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1055\/s-2003-45098","article-title":"Purification of gastxoprotective txiterpenoids from the stem bark of Amphipterugium adstringens; role of prostaglandins, sulfhydryls, nitric oxide and capsaicin-sensitive neurons","volume":"69","author":"Arrieta","year":"2003","journal-title":"Planta Med."},{"key":"2024103109352232900_cit2","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/00001574-200311000-00003","article-title":"Gastroduodenal mucosal defense: an integrated protective response","volume":"19","author":"Bi","year":"2003","journal-title":"Curr. 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