{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:52:59Z","timestamp":1791831179220,"version":"4.3.4"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Baccharis dracunculifolia is the most important botanical source of Southeastern Brazilian propolis, known as green propolis for its colour. In a previous study, we described the gastric protective effect of the hydroalcoholic extract of Brazilian green propolis. We therefore wanted to investigate the possibility of using B. dracunculifolia extract for antiulcer treatment. This study was undertaken to evaluate the anti-ulcerogenic property of hydroalcoholic extract of B. dracunculifolia aerial parts. The HPLC analysis of the chemical composition of B. dracunculifolia extract used in this study revealed the presence mainly of cinnamic acid derivates and flavonoids. Doses of 50, 250 and 500 mg\/kg of B. dracunculifolia crude extract and positive controls (omeprazole or cimetidine) significantly diminished the lesion index, the total lesion area and the percentage of lesion compared with negative control groups. The percentage of ulcer inhibition was significantly higher in groups treated with B. dracunculifolia, cimetidine or omeprazole, with all protocols used, compared with negative control groups. Regarding the model of gastric secretion, reductions in the volume of gastric juice and total acidity were observed, as well as an increase in the gastric pH. These results were similar to results from studies carried out with green propolis extract. Although more investigations are required, our results suggest that B. dracunculifolia has potential to be used as a phytotherapic preparation for the treatment of gastric ulcer.<\/jats:p>","DOI":"10.1211\/jpp.59.4.0017","type":"journal-article","created":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T19:16:18Z","timestamp":1175454978000},"page":"603-608","source":"Crossref","is-referenced-by-count":70,"title":["<i>Baccharis dracunculifolia<\/i>\n                    , the main botanical source of Brazilian green propolis, displays antiulcer activity"],"prefix":"10.1093","volume":"59","author":[{"given":"Marivane","family":"Lemos","sequence":"first","affiliation":[{"name":"N\u00facleo de Ci\u00eancia e Tecnologia, \u00c1rea de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade do Oeste de Santa Catarina , Campus de Videira, Rua Paese, 198, Bairro das Torres, Videira-SC, 89560-000, SC,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel Primon","family":"De Barros","sequence":"additional","affiliation":[{"name":"N\u00facleo de Ci\u00eancia e Tecnologia, \u00c1rea de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade do Oeste de Santa Catarina , Campus de Videira, Rua Paese, 198, Bairro das Torres, Videira-SC, 89560-000, SC,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Paulo Barreto","family":"Sousa","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ademar Alves da Silva","family":"Filho","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Ci\u00eancias Exatas e Tecnol\u00f3gicas, Universidade de Franca , Av. Dr. Armando Salles Oliveira, 201 - Parque Universit\u00e1rio, 14404-600, Franca, S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jairo Kenupp","family":"Bastos","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio Faloni","family":"De Andrade","sequence":"additional","affiliation":[{"name":"N\u00facleo de Ci\u00eancia e Tecnologia, \u00c1rea de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade do Oeste de Santa Catarina , Campus de Videira, Rua Paese, 198, Bairro das Torres, Videira-SC, 89560-000, SC,","place":["Brazil"]},{"name":"Programa de Mestrado em Ci\u00eancias Farmac\u00eauticas, N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed - UNIVALI , Itaja\u00ed, Santa Catarina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,4,1]]},"reference":[{"key":"2024103109353404000_cit1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jep.2005.08.024","article-title":"Anti-inflammatory activity of four Bolivian Baccharis species (Compositae)","volume":"103","author":"Abad","year":"2006","journal-title":"J. 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Ethnopharmacol."},{"key":"2024103109353404000_cit5","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1021\/np980028c","article-title":"Chemical constituents of Brazilian propolis and their cytotoxic activities","volume":"61","author":"Banskota","year":"1998","journal-title":"J. Nat. 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