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The gastrointestinal transit was observed with gamma-scintigraphy at various intervals over a 9-h period to give an accurate assessment of the transit characteristics. The value for the median emptying time of the first light tablet was significantly shorter than that for the dense tablet, but the total emptying time and the time for the last tablet to empty for both sets of tablets were not statistically different. The value of the median time for initial and final emptying of the small tablets from the stomach was significantly longer than that for the larger diameter tablets. The 9-h time limit of the observations limited the estimation of the time taken to enter the caecum and consequently the small intestine transit times. There was clear evidence that for the dense tablets of all sizes, the value for the small intestine transit time was longer than the 3\u20134 h reported in the literature. The only tablet system to enter the caecum within the time limit of the study was the normal density 12.2-mm tablets.<\/jats:p>","DOI":"10.1211\/jpp.59.7.0005","type":"journal-article","created":{"date-parts":[[2007,7,7]],"date-time":"2007-07-07T17:44:06Z","timestamp":1183830246000},"page":"941-945","source":"Crossref","is-referenced-by-count":19,"title":["Gastrointestinal transit of model mini-tablet controlled release oral dosage forms in fasted human volunteers"],"prefix":"10.1093","volume":"59","author":[{"given":"F","family":"Podczeck","sequence":"first","affiliation":[{"name":"School of Health, Natural and Social Sciences, Pasteur Building, Sunderland University , City Centre Campus, Warncliffe Street, Sunderland SR1 3SD,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Course","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of London , Brunswick Square, London WC1N 1AX,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Newton","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of London , Brunswick Square, London WC1N 1AX,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M B","family":"Short","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, University College London , Gower Street, London WC2E 6AD,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,7,1]]},"reference":[{"key":"2024103109351865500_cit1","volume-title":"Gastrointestinal transit of tablets of different size and density","author":"Course","year":"1992"},{"key":"2024103109351865500_cit2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.2042-7158.1992.tb03577.x","article-title":"Stomach outline visualisation in gastrointestinal transit studies using gamma scintigraphy","volume":"44","author":"Course","year":"1992","journal-title":"J. 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