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(TFB) against carbon tetrachloride (CCI4)-induced acute liver injury in mice and to determine its mechanism of action. Oral administration of TFB at doses of 50, 100 and 200 mg kg\u22121 for 7 days significantly reduced the elevated relative values of liver weight, serum transaminases (alanine aminotransferase and aspartate aminotransferase) and the hepatic morphologic changes induced by CCl4 in mice. In addition, TFB markedly inhibited CCl4-induced lipid peroxidation and enhanced the activity of the antioxidant enzymes superoxide dismutase and glutathione peroxidase. Moreover, pretreatment with TFB suppressed nitric oxide production and nuclear factor-kB activation in CCl4-treated mice. The results suggest that TFB has significant hepatoprotective activity and its mechanism is related, at least in part, to its antioxidant properties. Further research is required to investigate the detailed mechanism of the protective effect of TFB on acute liver injury.<\/jats:p>","DOI":"10.1211\/jpp.59.7.0015","type":"journal-article","created":{"date-parts":[[2007,7,7]],"date-time":"2007-07-07T17:44:06Z","timestamp":1183830246000},"page":"1017-1025","source":"Crossref","is-referenced-by-count":17,"title":["Protective effect of total flavonoids from<i>Bidens bipinnata<\/i>L. against carbon tetrachloride-induced liver injury in mice"],"prefix":"10.1093","volume":"59","author":[{"given":"Ming-mei","family":"Zhong","sequence":"first","affiliation":[{"name":"School of Pharmacy, Anhui Medical University , 81 Meishan Road, Hefei,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei-hu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Anhui Medical University , 81 Meishan Road, Hefei,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-ping","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Anhui Medical University , 81 Meishan Road, Hefei,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Anhui Institute of Medical Sciences , 15 Yonghong Road, Hefei,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan-rong","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Anhui Medical University , 81 Meishan Road, Hefei,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng-lai","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Anhui Medical University , 81 Meishan Road, Hefei,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-ming","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Anhui Medical University , 81 Meishan Road, Hefei,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,7,1]]},"reference":[{"key":"2024103109353753100_cit1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0378-8741(99)00092-6","article-title":"Gastric antisecretory and antiulcer activities of an ethanolic extract of Bidens pilosa L. var. radiata Schult. 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