{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:25:20Z","timestamp":1789809920755,"version":"4.0.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Semen Ziziphus jujuba (SZJ) has long been used in Chinese traditional medicine for the treatment of anxiety and insomnia because of its effect of decreasing monoaminergic system activity; saponins are thought to be the main bioactive factors. To investigate the sedative and hypnotic effects of saponins from SZJ, silica gel column chromatography and thin-layer chromatography were used to purify the crude extract of total saponins from SZJ. High-performance liquid chromatography showed that saponins from SZJ comprised two components, compounds I and II. Animal tests were conducted using these two compounds to compare their sedative and hypnotic effects. Results showed that both compounds had a significant effect (P &amp;lt; 0.05, P &amp;lt; 0.01) on walking time compared with that of the control group. Compound I had a significant effect on coordinated movement (P &amp;lt; 0.05). Both compounds prolonged the suprathreshold barbiturate induced sleeping time (P &amp;lt; 0.05). The number of sleeping animals increased by 30% and 20% for compounds I and II, respectively, under the sub-threshold dose of sodium barbital.<\/jats:p>","DOI":"10.1211\/jpp.59.8.0017","type":"journal-article","created":{"date-parts":[[2007,8,24]],"date-time":"2007-08-24T00:07:47Z","timestamp":1187914067000},"page":"1175-1180","source":"Crossref","is-referenced-by-count":45,"title":["Separation and purification of saponins from Semen <i>Ziziphus jujuba<\/i> and their sedative and hypnotic effects"],"prefix":"10.1093","volume":"59","author":[{"given":"Jian-Guo","family":"Jiang","sequence":"first","affiliation":[{"name":"College of Food and Bioengineering, South China University of Technology , Guangzhou, 510640,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Juan","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Food and Bioengineering, South China University of Technology , Guangzhou, 510640,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Food and Bioengineering, South China University of Technology , Guangzhou, 510640,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,8,1]]},"reference":[{"key":"2024103109354529300_cit1","first-page":"314","article-title":"Sedative and hypnotic effects of the fermentative broth of Cordyceps Sisnensi","volume":"40","author":"Cao","year":"2005","journal-title":"Acta Universitatis Medicinalis Anhui"},{"key":"2024103109354529300_cit2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.phymed.2004.03.006","article-title":"Pharmacological studies on the sedative and hypnotic effect of Kava kava and Passiflora extracts combination","volume":"12","author":"Capasso","year":"2005","journal-title":"Phytomedicine"},{"key":"2024103109354529300_cit3","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1248\/bpb.25.1629","article-title":"Anxiolytic and sedative effects of extracts and essential oil from Citrus aurantium L","volume":"25","author":"Carvalho-Freitas","year":"2002","journal-title":"Biol. 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