{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:44:32Z","timestamp":1787319872872,"version":"build-2736575974"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Punica granatum L. (pomegranate) is a widely used plant that has high nutritional value. The aim of this study was to assess the effect of chronic administration of pomegranate peel extract (PPE) on liver fibrosis induced by bile duct ligation (BDL) in rats. PPE (50 mg kg\u22121) or saline was administered orally for 28 days. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) levels were determined to assess liver function and tissue damage. Proinflammatory cytokines (tumor necrosis factor-alpha and interleukin 1 beta) in the serum and anti-oxidant capacity (AOC) were measured in plasma samples. Samples of liver tissue were taken for measurement of hepatic malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity and collagen content. Production of reactive oxidants was monitored by chemilumi-nescence assay. Serum AST, ALT, LDH and cytokines were elevated in the BDL group compared with the control group; this increase was significantly decreased by PPE treatment. Plasma AOC and hepatic GSH levels were significantly depressed by BDL but were increased back to control levels in the PPE-treated BDL group. Increases in tissue MDA levels and MPO activity due to BDL were reduced back to control levels by PPE treatment. Similarly, increased hepatic collagen content in the BDL rats was reduced to the level of the control group with PPE treatment. Thus, chronic PPE administration alleviated the BDL-induced oxidative injury of the liver and improved the hepatic structure and function. It therefore seems likely that PPE, with its antioxidant and antifibrotic properties, may be of potential therapeutic value in protecting the liver from fibrosis and oxidative injury due to biliary obstruction.<\/jats:p>","DOI":"10.1211\/jpp.59.9.0014","type":"journal-article","created":{"date-parts":[[2007,9,8]],"date-time":"2007-09-08T13:52:27Z","timestamp":1189259547000},"page":"1287-1295","source":"Crossref","is-referenced-by-count":66,"title":["Pomegranate peel extract prevents liver fibrosis in biliary-obstructed rats"],"prefix":"10.1093","volume":"59","author":[{"given":"Hale Z","family":"Toklu","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Marmara University , Istanbul,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozer","family":"Sehirli","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Marmara University , Istanbul,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goksel","family":"Sener","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Marmara University , Istanbul,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melek U","family":"Dumlu","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, School of Pharmacy, Marmara University , Istanbul,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feriha","family":"Ercan","sequence":"additional","affiliation":[{"name":"Department of Histology - Embryology, School of Medicine, Marmara University , Istanbul,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nursal","family":"Gedik","sequence":"additional","affiliation":[{"name":"Division of Biochemistry, Kasimpasa Military Hospital , Istanbul,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vural","family":"G\u00f6kmen","sequence":"additional","affiliation":[{"name":"Department of Food Engineering, Hacettepe University , 06800 Beytepe, Ankara,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,9,1]]},"reference":[{"key":"2024103109354033300_cit1","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1021\/jf052005r","article-title":"Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells","volume":"54","author":"Adams","year":"2006","journal-title":"J. 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