{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:01:22Z","timestamp":1792101682116,"version":"4.4.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Forsythia suspensa (Thunb.) Vahl. has been widely used in traditional medicines in Asia to treat gonorrhoea, erysipelas, inflammation, pyrexia, ulcer and other diseases. Recently the investigation has been focused on the antioxidant and antibacterial activity of this plant. However, limited scientifically proven information is available. We isolated two compounds (forsythiaside and forsythin) from this plant. The aims of this investigation, therefore, were to assay antioxidant activity and antibacterial properties of the two main and distinctive compounds isolated and to exploit antioxidants and antibacterial agents from natural compounds. The antioxidant activity was estimated using the 1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity method and the in-vitro antimicrobial activity was evaluated by microtitre plate method. Forsythiaside was found to possess strong antioxidant and antibacterial activity but forsythin was much weaker. Owing to these properties, the study can be further extended to exploit the possible application of forsythiaside as an alternative antioxidant and antibacterial agent of natural origin.<\/jats:p>","DOI":"10.1211\/jpp.60.2.0016","type":"journal-article","created":{"date-parts":[[2008,1,21]],"date-time":"2008-01-21T19:48:07Z","timestamp":1200944887000},"page":"261-266","source":"Crossref","is-referenced-by-count":127,"title":["Antioxidant and antibacterial activity of two compounds (forsythiaside and forsythin) isolated from\n                    <i>Forsythia suspensa<\/i>"],"prefix":"10.1093","volume":"60","author":[{"given":"Huanhuan","family":"Qu","sequence":"first","affiliation":[{"name":"Biology and Medicine Key Laboratory of Shaanxi Province, Northwest University , Xi'an 710069,","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmin","family":"Zhang","sequence":"additional","affiliation":[{"name":"CNRS-UMR 8642, Departement de Chimie, Ecole Normale Superieure , 24 rue Lhomond, 75231 Paris Cedex 05,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Molecular Microbiology Laboratory, Northwest University , Xi'an 710069,","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baixue","family":"Li","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine , Chengdu 610075,","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenji","family":"Sun","sequence":"additional","affiliation":[{"name":"Biology and Medicine Key Laboratory of Shaanxi Province, Northwest University , Xi'an 710069,","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,2,1]]},"reference":[{"key":"2024103109360437600_cit1","doi-asserted-by":"crossref","first-page":"6292","DOI":"10.1021\/jf000849z","article-title":"Influence of jam processing on the radical scavenging activity and phenolic content in berries","volume":"48","author":"Amakura","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"2024103109360437600_cit2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0023-6438(95)80008-5","article-title":"Use of a free radical method to evaluate antioxidant activity","volume":"28","author":"Brand-Williams","year":"1995","journal-title":"Lebensm.-Wiss. Technol."},{"key":"2024103109360437600_cit3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ijfoodmicro.2004.03.022","article-title":"Essential oils: their antibacterial properties and potential applications in foods: a review","volume":"94","author":"Burt","year":"2004","journal-title":"Int. J. Food Microbiol."},{"key":"2024103109360437600_cit4","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1021\/jf9602535","article-title":"Antioxidant capacity of tea and common vegetables","volume":"44","author":"Cao","year":"1996","journal-title":"J. Agric. Food Chem."},{"key":"2024103109360437600_cit5","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1021\/jf0100907","article-title":"Antioxidant activity of extracts from Acacia confusa bark and heartwood","volume":"49","author":"Chang","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"2024103109360437600_cit6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1207\/S15327914NC3701_1","article-title":"Dietary antioxidants during cancer chemotherapy: impact on chemotherapeutic effectiveness and development of side effects","volume":"37","author":"Conklin","year":"2000","journal-title":"Nutr. Cancer."},{"key":"2024103109360437600_cit7","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1039\/b602147f","article-title":"Kinetics of the reaction between the antioxidant Trolox and the free radical DPPH\u02d9 in semi-aqueous solution","volume":"4","author":"Friaa","year":"2006","journal-title":"Org. Biomol. Chem."},{"key":"2024103109360437600_cit8","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.4315\/0362-028X-65.10.1545","article-title":"Bactericidal activities of plant essential oils and some of their isolated constituents against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, and Salmonella enterica","volume":"65","author":"Friedman","year":"2002","journal-title":"J. Food Prot."},{"key":"2024103109360437600_cit9","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1111\/j.1365-2621.2003.tb09678.x","article-title":"Assessment of the antioxidant properties during storage of a dessert made from grape, cherry, and berries","volume":"68","author":"Garc\u00eda-Alonso","year":"2003","journal-title":"J. Food Sci."},{"key":"2024103109360437600_cit10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s002170000184","article-title":"Ellagic acid content in berries: influence of domestic processing and storage","volume":"212","author":"H\u00e4kkinen","year":"2000","journal-title":"Eur. Food Res. Technol."},{"key":"2024103109360437600_cit11","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1111\/j.1365-2621.2005.tb09053.x","article-title":"Effects of production and processing factors on major fruit and vegetable antioxidants","volume":"70","author":"Kalt","year":"2005","journal-title":"J. Food Sci."},{"key":"2024103109360437600_cit12","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/10408690490464960","article-title":"Comprehensive study on vitamin C equivalent antioxidant capacity (VCEAC) of various polyphenolics in scavenging a free radical and its structural relationship","volume":"44","author":"Kim","year":"2004","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"2024103109360437600_cit13","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1749-6632.2001.tb05654.x","article-title":"Do antioxidant strategies work against aging and age-associated disorders? Proparylamines: a possible antioxidant strategy","volume":"928","author":"Kitani","year":"2001","journal-title":"Ann. NY Acad. Sci."},{"key":"2024103109360437600_cit14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.295.5553.233","article-title":"The future of medicine","volume":"295","author":"Koop","year":"2002","journal-title":"Science."},{"key":"2024103109360437600_cit15","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.chroma.2005.06.025","article-title":"Preparative isolation and purification of phillyrin from the medicinal plant Forsythia suspensa by high-speed counter-current chromatography","volume":"1083","author":"Li","year":"2005","journal-title":"J. Chromatogr. A"},{"key":"2024103109360437600_cit16","first-page":"112","article-title":"Studies on the antibiotic and antioxidant activities of weeping forsythia applied in Chinese-style sausage","volume":"22","author":"Li","year":"2006","journal-title":"Chin. Agric. Sci. Bull."},{"key":"2024103109360437600_cit17","first-page":"102","article-title":"Measuring the antiradical efficiency of proanthocyanidin from grape seed by the DPPH assay","volume":"25","author":"Li","year":"2006","journal-title":"J. Food Sci. Biotechnol."},{"key":"2024103109360437600_cit18","first-page":"327","volume-title":"Study on the common traditional Chinese medicines","author":"Liang","year":"2003"},{"key":"2024103109360437600_cit19","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1021\/np970369a","article-title":"New quinoid glycosides from Forsythia suspensa","volume":"61","author":"Ming","year":"1998","journal-title":"J. Nat. Prod."},{"key":"2024103109360437600_cit20","doi-asserted-by":"crossref","first-page":"4548","DOI":"10.1248\/cpb.30.4548","article-title":"Studies on the Chinese crude drug Forsythiae Fructus. VI. The structure and antibacterial activity of suspensaside isolated from Forsythia suspensa","volume":"30","author":"Nishibe","year":"1992","journal-title":"Chem. Pharm. Bull."},{"key":"2024103109360437600_cit21","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1142\/S0192415X06004041","article-title":"Antimicrobial activities of cinnamon oil and cinnamaldehyde from the Chinese medicinal herb Cinnamomum cassia Blume","volume":"34","author":"Ooi","year":"2006","journal-title":"Am. J. Chin. Med."},{"key":"2024103109360437600_cit22","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1248\/bpb.20.861","article-title":"Anti inflammatory effect of Forsythia suspensa Vahl and its active fraction","volume":"20","author":"Ozaki","year":"1997","journal-title":"Biol. Pharm. Bull."},{"key":"2024103109360437600_cit23","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1021\/jf980145d","article-title":"Antioxidant capacity as influenced by total phenolics and anthocyanin content, maturity and variety of vaccinum species","volume":"26","author":"Prior","year":"1998","journal-title":"J. Agric. Food Chem."},{"key":"2024103109360437600_cit24","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ijfoodmicro.2007.03.003","article-title":"The in vitro antibacterial activity of dietary spice and medicinal herb extracts","volume":"117","author":"Shan","year":"2007","journal-title":"Int. J. Food Microbiol."},{"key":"2024103109360437600_cit25","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/BF02682653","article-title":"Oxidation and antioxidants in fat and oil processing","volume":"55","author":"Sherwin","year":"1978","journal-title":"J. Am. Oil Chem. Soc."},{"key":"2024103109360437600_cit26","first-page":"3539","volume-title":"The United States Pharmacopeia","author":"USP","year":"2006"},{"key":"2024103109360437600_cit27","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1021\/jf9801973","article-title":"Antioxidant activity and total phenolics in selected fruits, vegetables, and grain products","volume":"46","author":"Velioglu","year":"1998","journal-title":"J. Agric. Food Chem."},{"key":"2024103109360437600_cit28","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1021\/jf0113575","article-title":"Profiling and characterization of antioxidant activities in Anoectochilus formasanus Hayata","volume":"50","author":"Wang","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"2024103109360437600_cit29","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1021\/jf010192x","article-title":"Effect of processing and storage on the antioxidant ellagic acid derivatives and flavonoids of red raspberry (Rubus idaeus) jams","volume":"49","author":"Zafrilla","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"2024103109360437600_cit30","first-page":"39","article-title":"A comparative study on bioactivities of tea polyphenols and chlorogenic acid","volume":"27","author":"Zhang","year":"2007","journal-title":"J. Tea Sci."},{"key":"2024103109360437600_cit31","first-page":"334","article-title":"Study on the antioxidant activity and structure-activity relationship of forsythiaside","volume":"38","author":"Zhang","year":"2003","journal-title":"Chin. Pharm. J."},{"key":"2024103109360437600_cit32","first-page":"157","article-title":"Study on the reducing blood lipid and antioxidation effects of phillyrin","volume":"17","author":"Zhao","year":"2005","journal-title":"Nat. Prod. Res. Dev."},{"key":"2024103109360437600_cit33","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s007690000256","article-title":"The role of reference materials","volume":"5","author":"Zschunke","year":"2000","journal-title":"Accredit. Qual. Assur."}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1211%2Fjpp.60.2.0016","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/60\/2\/261\/60256040\/jpp.60.2.0016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/60\/2\/261\/60256040\/jpp.60.2.0016.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T05:48:32Z","timestamp":1730353712000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/60\/2\/261\/6148013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,1]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,2,1]]},"published-print":{"date-parts":[[2008,2,1]]}},"URL":"https:\/\/doi.org\/10.1211\/jpp.60.2.0016","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"value":"0022-3573","type":"print"},{"value":"2042-7158","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2008,2]]},"published":{"date-parts":[[2008,2,1]]}}}