{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T05:46:26Z","timestamp":1772257586249,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chronic ethanol consumption and hypertension are related. In the current study we investigated whether changes in reactivity of the mesenteric arterial bed could account for the increased blood pressure associated with chronic ethanol intake. Changes in reactivity to phenylephrine and acetylcholine were investigated in the perfused mesenteric bed from rats treated with ethanol for 2 or 6 weeks and their age-matched controls. Mild hypertension was observed in chronically ethanol-treated rats. Treatment of rats for 6 weeks induced an increase in the contractile response of endothelium-intact mesenteric bed to phenylephrine, but not denuded rat mesenteric bed. The phenylephrine-induced increase in perfusion pressure was not altered after 2 weeks' treatment with ethanol. Moreover, acetylcholine-induced endothelium-dependent relaxation was reduced by ethanol treatment for 6 weeks, but not 2 weeks. Pre-treatment with indometacin, a cyclooxygenase inhibitor, reduced the maximum effect induced by phenylephrine (Emax) in endothelium-intact mesenteric bed from both control and ethanol-treated rats. No differences in the Emax values for phenylephrine were observed between groups in the presence of indometacin. l-NNA, a nitric oxide (NO) synthase (NOS) inhibitor, increased the Emax for phenylephrine in endothelium-intact mesenteric bed from control rats but not from ethanol-treated rats. Levels of endothelial NOS (eNOS) mRNA were not altered by chronic ethanol consumption. However, chronic ethanol intake strongly reduced eNOS protein levels in the mesenteric bed. This study shows that chronic ethanol consumption increases blood pressure and alters the reactivity of the mesenteric bed. Moreover, the increased vascular response to phenylephrine observed in the mesenteric bed is maintained by two mechanisms: an increased release of endothelial-derived vasoconstrictor prostanoids and a reduced modulatory action of endothelial NO, which seems to be associated with reduced post-transcriptional expression of eNOS.<\/jats:p>","DOI":"10.1211\/jpp.60.3.0008","type":"journal-article","created":{"date-parts":[[2008,2,13]],"date-time":"2008-02-13T00:57:30Z","timestamp":1202864250000},"page":"331-341","source":"Crossref","is-referenced-by-count":34,"title":["Ethanol consumption increases blood pressure and alters the responsiveness of the mesenteric vasculature in rats"],"prefix":"10.1093","volume":"60","author":[{"given":"Carlos R","family":"Tirapelli","sequence":"first","affiliation":[{"name":"Department of Psychiatric Nursing and Human Sciences, College of Nursing of Ribeir\u00e3o Preto, University of S\u00e3o Paulo , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreia F C","family":"Leone","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Nephrology Division, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro","family":"Yogi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Biomedical Sciences, University of S\u00e3o Paulo , S\u00e3o Paulo, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita C","family":"Tostes","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Biomedical Sciences, University of S\u00e3o Paulo , S\u00e3o Paulo, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera L","family":"Lanchote","sequence":"additional","affiliation":[{"name":"Department of Clinical, Toxicological and Food Science Analysis, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio A","family":"Uyemura","sequence":"additional","affiliation":[{"name":"Department of Clinical, Toxicological and Food Science Analysis, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo B M","family":"Resstel","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo , SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando M A","family":"Corr\u00eaa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo , SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia M","family":"Padovan","sequence":"additional","affiliation":[{"name":"Department of Psychology and Education, Faculty of Philosophy and Sciences, University of S\u00e3o Paulo , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana M","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Physics and Chemistry, Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo B","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Nephrology Division, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,3,1]]},"reference":[{"key":"2024103109363271800_cit1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1161\/01.HYP.10.1.67","article-title":"Ethanol-induced hypertension involves impairment of baroreceptors","volume":"10","author":"Abdel-Rahman","year":"1987","journal-title":"Hypertension"},{"key":"2024103109363271800_cit2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/00005344-199303000-00011","article-title":"Varying extracellular [K+]; a functional approach to separating EDHF- and EDNO-related mechanisms in perfused rat mesenteric arterial bed","volume":"21","author":"Adeagbo","year":"1993","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"2024103109363271800_cit3","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/00004872-199207000-00007","article-title":"Effect of chronic ethanol consumption upon cardiovascular reactivity, heart rate and blood pressure in spontaneously hypertensive and Wistar-Kyoto rats","volume":"10","author":"Beilin","year":"1992","journal-title":"J. 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