{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T20:54:12Z","timestamp":1766609652281,"version":"3.28.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Resorcinol derivatives are known to inhibit melanin synthesis. In this study, resorcinol derivatives were synthesized and screened for their activity on melanogenesis. KI-063 (a tyrosinase inhibitor) was examined for its effects on melanogenesis using a spontaneously immortalized mouse melanocyte cell line (Mel-Ab). In a cell-free system, KI-063 directly inhibited tyrosinase, the rate-limiting melanogenic enzyme. Moreover, in a cell system, it inhibited melanin synthesis in a concentration-dependent manner. In addition, KI-063 inhibited the activity of cellular tyrosinase. Thus, this study examined the effects of a combination of KI-063 with terrein, an agent that down-regulates microphthalmia-associated transcription factor. The data suggest that KI-063 has an additive effect in combination with terrein. Thus, the suppression of tyrosinase activity by KI-063 and the inhibition of tyrosinase production by terrein appear to be an optimal combination for skin whitening.<\/jats:p>","DOI":"10.1211\/jpp.60.3.0009","type":"journal-article","created":{"date-parts":[[2008,2,13]],"date-time":"2008-02-13T00:57:30Z","timestamp":1202864250000},"page":"343-348","source":"Crossref","is-referenced-by-count":11,"title":["The hypopigmentary action of KI-063 (a new tyrosinase inhibitor) combined with terrein"],"prefix":"10.1093","volume":"60","author":[{"given":"Dong-Seok","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biochemistry, College of Medicine, Chung-Ang University , 221 Heukseok-Dong Dongjak-Gu, Seoul 156-756,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangku","family":"Lee","sequence":"additional","affiliation":[{"name":"National Cosmeceutical Research Center, Korea Research Institute of Bioscience and Biotechnology , 52 Oeun-Dong, Yuseong-Gu, Daejeon 305-333,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Kyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University College of Medicine , 28 Yongon-Dong, Chongno-Gu, Seoul 110-744,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seo-Hyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University College of Medicine , 28 Yongon-Dong, Chongno-Gu, Seoul 110-744,","place":["Republic of Korea"]},{"name":"Welskin Co. 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Ltd , 28 Yongon-Dong, Chongno-Gu, Seoul 110-744,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang Jin","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine, Chung-Ang University , 221 Heukseok-Dong Dongjak-Gu, Seoul 156-756,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Im","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University College of Medicine , 28 Yongon-Dong, Chongno-Gu, Seoul 110-744,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung-Chan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University College of Medicine , 28 Yongon-Dong, Chongno-Gu, Seoul 110-744,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,3,1]]},"reference":[{"key":"2024103109362817200_cit1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/sj.jid.5700683","article-title":"Approaches to identify inhibitors of melanin biosynthesis via the quality control of tyrosinase","volume":"127","author":"Ando","year":"2007","journal-title":"J. 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