{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:50:03Z","timestamp":1790383803726,"version":"4.1.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inflammation is a pivotal component of a variety of diseases, such as atherosclerosis and tumour progression. Various naturally occurring phytochemicals exhibit anti-inflammatory activity and are considered to be potential drug candidates against inflammation-related pathological processes. Capsicum baccatum L. var. pendulum (Willd.) Eshbaugh (Solanaceae) is the most consumed species in Brazil, and its compounds, such as capsaicinoids, have been found to inhibit the inflammatory process. However, the anti-inflammatory effects of C. baccatum have not been characterized. Thus, this study was designed to evaluate the effects of C. baccatum juice in animal models of acute inflammation induced by carrageenan and immune inflammation induced by methylated bovine serum albumin. Pretreatment (30 min) of rats with pepper juice (0.25\u20132.0 g kg\u22121) significantly decreased leucocyte and neutrophil migration, exudate volume and protein and LDH concentration in pleural exudates of a pleurisy model. This juice also inhibited neutrophil migration and reduced the vascular permeability on carrageenan-induced peritonitis in mice. C. baccatum juice also reduced neutrophil recruitment and exudate levels of pro-inflammatory cytokines TNF-\u03b1 and IL-1\u03b2 in mouse inflammatory immune peritonitis. Furthermore, we demonstrated that the main constituent of C. baccatum juice, as extracted with chloroform, is capsaicin. In agreement with this, capsaicin was able to inhibit the neutrophil migration towards the inflammatory focus. To our knowledge, this is the first demonstration of the anti-inflammatory effect of C. baccatum juice and our data suggest that this effect may be induced by capsaicin. Moreover, the anti-inflammatory effect induced by red pepper may be by inhibition of pro-inflammatory cytokine production at the inflammatory site.<\/jats:p>","DOI":"10.1211\/jpp.60.4.0010","type":"journal-article","created":{"date-parts":[[2008,3,14]],"date-time":"2008-03-14T01:04:59Z","timestamp":1205456699000},"page":"473-478","source":"Crossref","is-referenced-by-count":112,"title":["Anti-inflammatory effects of red pepper (<i>Capsicum baccatum<\/i>) on carrageenan- and antigen-induced inflammation"],"prefix":"10.1093","volume":"60","author":[{"given":"Fernando","family":"Spiller","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia K","family":"Alves","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Biophysics and Inflammation, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS) , Porto Alegre, RS,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00edlvio M","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo , Ribeir\u00e3o Preto, SP,","place":["Brazil"]},{"name":"Laboratory of Pharmacology, Instituto Nacional de Pesquisas da Amazonia , Manaus, AM,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni A","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E","family":"Leite","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Biophysics and Inflammation, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS) , Porto Alegre, RS,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adroaldo","family":"Lunardelli","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Biophysics and Inflammation, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS) , Porto Alegre, RS,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A","family":"Poloni","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Biophysics and Inflammation, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS) , Porto Alegre, RS,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Q","family":"Cunha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarbas R","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Biophysics and Inflammation, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS) , Porto Alegre, RS,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,4,1]]},"reference":[{"key":"2024103109364359800_cit1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.phrs.2003.10.009","article-title":"Anti-inflammatory effects of fructose-1,6-bisphosphate on carrageenan-induced pleurisy in rat","volume":"49","author":"Filho","year":"2004","journal-title":"Pharmacol. Res."},{"key":"2024103109364359800_cit2","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1080\/03601230600857114","article-title":"Antioxidants in hot pepper: variation among accessions","volume":"41","author":"Antonious","year":"2006","journal-title":"J. Environ. Sci. Health B"},{"key":"2024103109364359800_cit3","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1055\/s-2003-45141","article-title":"Anti-inflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor kappa B (NF-kappaB)","volume":"69","author":"Calixto","year":"2003","journal-title":"Planta Med."},{"key":"2024103109364359800_cit4","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1093\/ajcn\/69.6.1086","article-title":"Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans","volume":"69","author":"Carr","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"2024103109364359800_cit5","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"2024103109364359800_cit6","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1126\/science.288.5464.306","article-title":"Impaired nociception and pain sensation in mice lacking the capsaicin receptor","volume":"288","author":"Caterina","year":"2000","journal-title":"Science"},{"key":"2024103109364359800_cit7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2174\/187152906779010737","article-title":"Anti-inflammatory effects of different drugs\/agents with antioxidant property on endothelial expression of adhesion molecules","volume":"6","author":"Chen","year":"2006","journal-title":"Cardiovasc. Hematol. Disord. Drug Targets"},{"key":"2024103109364359800_cit8","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1080\/10408399109527536","article-title":"Capsicum\u2014production, technology, chemistry, and quality. Part V. Impact on physiology, pharmacology, nutrition, and metabolism; structure, pungency, pain, and desensitization sequences","volume":"29","author":"Govindarajan","year":"1991","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"2024103109364359800_cit9","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1001\/archinte.1991.00400110079017","article-title":"Treatment of painful diabetic neuropathy with topical capsaicin. A multicenter, double-blind, vehicle-controlled study","volume":"151","author":"Group","year":"1991","journal-title":"Arch. Intern. Med."},{"key":"2024103109364359800_cit10","first-page":"143","article-title":"Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons","volume":"43","author":"Holzer","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"2024103109364359800_cit11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0898-6568(02)00086-4","article-title":"Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophages","volume":"15","author":"Kim","year":"2003","journal-title":"Cell Signal."},{"key":"2024103109364359800_cit12","first-page":"1735","article-title":"Pulmonary response to inhaled antigen: neuroimmune interactions promote the recruitment of dendritic cells to the lung and the cellular immune response to inhaled antigen","volume":"150","author":"Kradin","year":"1997","journal-title":"Am. J. Pathol."},{"key":"2024103109364359800_cit13","first-page":"164","volume-title":"Dicion\u00e1rio gastron\u00f4mico: pimentas com suas receitas.","author":"Linguanotto","year":"2004"},{"key":"2024103109364359800_cit14","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00011-006-0008-x","article-title":"Extract of the bristles of Dirphia sp. increases nitric oxide in a rat pleurisy model","volume":"55","author":"Lunardelli","year":"2006","journal-title":"Inflamm. Res."},{"key":"2024103109364359800_cit15","doi-asserted-by":"crossref","first-page":"4528","DOI":"10.1111\/j.1742-4658.2006.05458.x","article-title":"Protective effect of dietary curcumin and capsaicin on induced oxidation of low-density lipo-protein, iron-induced hepatotoxicity and carrageenan-induced inflammation in experimental rats","volume":"273","author":"Manjunatha","year":"2006","journal-title":"FEBS J."},{"key":"2024103109364359800_cit16","first-page":"604","article-title":"Effect of topical capsaicin in the therapy of painful osteoarthritis of the hands","volume":"19","author":"McCarthy","year":"1992","journal-title":"J. Rheumatol."},{"key":"2024103109364359800_cit17","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/intimm\/dxl007","article-title":"IL-1beta, but not IL-1alpha, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed-type hypersensitivity responses","volume":"18","author":"Nambu","year":"2006","journal-title":"Int. Immunol."},{"key":"2024103109364359800_cit18","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.febslet.2004.06.084","article-title":"Capsaicin inhibits the production of tumor necrosis factor alpha by LPS-stimulated murine macrophages, RAW 264.7: a PPARgamma ligand-like action as a novel mechanism","volume":"572","author":"Park","year":"2004","journal-title":"FEBS Lett."},{"key":"2024103109364359800_cit19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1189\/jlb.0404237","article-title":"MIP-1alpha[CCL3] acting on the CCR1 receptor mediates neutrophil migration in immune inflammation via sequential release of TNF-alpha and LTB4","volume":"78","author":"Ramos","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"2024103109364359800_cit20","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S0278-6915(02)00037-6","article-title":"Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review","volume":"40","author":"Surh","year":"2002","journal-title":"Food. Chem. Toxicol."},{"key":"2024103109364359800_cit21","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/0024-3205(95)00159-4","article-title":"Capsaicin, a double-edged sword: toxicity, metabolism, and chemopreventive potential","volume":"56","author":"Surh","year":"1995","journal-title":"Life Sci."},{"key":"2024103109364359800_cit22","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0278-6915(95)00108-5","article-title":"Capsaicin in hot chili pepper: carcinogen, co-carcinogen or anticarcinogen","volume":"34","author":"Surh","year":"1996","journal-title":"Food Chem. Toxicol."},{"key":"2024103109364359800_cit23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0031-6997(24)01403-0","article-title":"Vanilloid (capsaicin) receptors and mechanisms","volume":"51","author":"Szallasi","year":"1999","journal-title":"Pharmacol. Rev."},{"key":"2024103109364359800_cit24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0022-1759(91)90243-9","article-title":"A solid phase enzyme immunoassay for serum amyloid A (SAA) protein. Clinical evaluation","volume":"136","author":"Taktak","year":"1991","journal-title":"J. Immunol. Methods"},{"key":"2024103109364359800_cit25","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/74725","article-title":"Angiopoietin-1 protects the adult vasculature against plasma leakage","volume":"6","author":"Thurston","year":"2000","journal-title":"Nat. Med."},{"key":"2024103109364359800_cit26","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/ajcp\/16.3_ts.40","article-title":"An accurate and rapid method for the determination of proteins in small amounts of blood serum and plasma","volume":"10","author":"Weichselbaum","year":"1946","journal-title":"Am. J. Clin. Pathol., Tech. Sect."},{"key":"2024103109364359800_cit27","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3349\/ymj.2005.46.5.585","article-title":"Molecular targets of dietary polyphenols with anti-inflammatory properties","volume":"46","author":"Yoon","year":"2005","journal-title":"Yonsei Med. J."},{"key":"2024103109364359800_cit28","first-page":"114","article-title":"Modulation of select immune responses by dietary capsaicin","volume":"68","author":"Yu","year":"1998","journal-title":"Int. J. Vitam. Nutr. Res."}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1211%2Fjpp.60.4.0010","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/60\/4\/473\/60256378\/jpp.60.4.0010.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/60\/4\/473\/60256378\/jpp.60.4.0010.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T03:03:51Z","timestamp":1738119831000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/60\/4\/473\/6148022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,1]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,4,1]]},"published-print":{"date-parts":[[2008,4,1]]}},"URL":"https:\/\/doi.org\/10.1211\/jpp.60.4.0010","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"value":"0022-3573","type":"print"},{"value":"2042-7158","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2008,4]]},"published":{"date-parts":[[2008,4,1]]}}}