{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:34:30Z","timestamp":1789479270457,"version":"build-2803163510"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Eugenia brasiliensis Lam., a plant from the south of Brazil, is used in the popular medicine for rheumatism treatment. This study reports that topical application of hydroalcoholic extract, fractions and isolated compounds from E. brasiliensis caused an inhibition of ear oedema in response to topical application of croton oil on the mouse ear. For oedema inhibition, the estimated ID50 values (dose reducing the inflammatory response by 50% relative to the control value) for hydroalcoholic extract and fractions (hexane, ethyl acetate and dichloromethane) were 0.17, 0.29, 0.13 and 0.14 mg\/ear, respectively, with inhibition of 79 \u00b1 7%, 87 \u00b1 6%, 88 \u00b1 5% and 96 \u00b1 2%, respectively. Isolated phenolic compounds (quercetin, catechin and gallocatechin) were also effective in inhibiting the oedema (inhibition of 61 \u00b1 5%, 66 \u00b1 2% and 37 \u00b1 9%, respectively). Moreover, both extract and isolated compounds caused inhibition of polymorphonuclear cells influx (inhibition of 85 \u00b1 6%, 81 \u00b1 5%, 73 \u00b1 6% and 76 \u00b1 6%, respectively). The histological analysis of the ear tissue clearly confirmed that the extract and compounds of E. brasiliensis inhibited the influx of polymorphonuclear cells to mouse ear skin after application of croton oil. Furthermore, hydroalcoholic extract was also effective in inhibiting the arachidonic acid-mediated mouse ear oedema (ID50 value was 1.94 mg\/ear and inhibition of 60 \u00b1 7%). Therefore, these results consistently support the notion that E. brasiliensis possesses topical anti-inflammatory activity.<\/jats:p>","DOI":"10.1211\/jpp.60.4.0011","type":"journal-article","created":{"date-parts":[[2008,3,14]],"date-time":"2008-03-14T01:04:59Z","timestamp":1205456699000},"page":"479-487","source":"Crossref","is-referenced-by-count":36,"title":["Topical anti-inflammatory activity of <i>Eugenia brasiliensis<\/i> Lam. (Myrtaceae) leaves"],"prefix":"10.1093","volume":"60","author":[{"given":"Evelise Fernandes","family":"Pietrovski","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Inflama\u00e7\u00e3o, Dor e Febre, Departamento de Farmacologia, Setor de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Paran\u00e1 , Centro Polit\u00e9cnico, Curitiba, PR,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele Debiasi Alberton","family":"Magina","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Farmac\u00eauticas, Universidade Regional de Blumenau , Blumenau, SC,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franciane","family":"Gomig","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Inflama\u00e7\u00e3o, Dor e Febre, Departamento de Farmacologia, Setor de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Paran\u00e1 , Centro Polit\u00e9cnico, Curitiba, PR,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Fernandes","family":"Pietrovski","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Inflama\u00e7\u00e3o, Dor e Febre, Departamento de Farmacologia, Setor de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Paran\u00e1 , Centro Polit\u00e9cnico, Curitiba, PR,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Amadeu","family":"Micke","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal de Santa Catarina , Florian\u00f3polis, SC,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Barcellos","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal de Santa Catarina , Florian\u00f3polis, SC,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moacir Geraldo","family":"Pizzolatti","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Produtos Naturais, Departamento de Qu\u00edmica, Universidade Federal de Santa Catarina , Florian\u00f3polis, SC,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Almeida","family":"Cabrini","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Inflama\u00e7\u00e3o, Dor e Febre, Departamento de Farmacologia, Setor de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Paran\u00e1 , Centro Polit\u00e9cnico, Curitiba, PR,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas Maria Costa","family":"Brighente","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Produtos Naturais, Departamento de Qu\u00edmica, Universidade Federal de Santa Catarina , Florian\u00f3polis, SC,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel Fleith","family":"Otuki","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Inflama\u00e7\u00e3o, Dor e Febre, Departamento de Farmacologia, Setor de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Paran\u00e1 , Centro Polit\u00e9cnico, Curitiba, PR,","place":["Brazil"]},{"name":"Departamento de Ci\u00eancias Farmac\u00eauticas, Universidade Estadual de Ponta Grossa , Ponta Grossa, PR,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,4,1]]},"reference":[{"key":"2024103109364798100_cit1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/B978-0-444-87449-8.50009-2","article-title":"Flavonoids","volume-title":"Carbon-13 NMR of flavonoids.","author":"Agrawal","year":"1989"},{"key":"2024103109364798100_cit2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF01966592","article-title":"Modulation of mouse ear edema by cyclooxygenase and lipoxygenase inhibitors and other pharmacologic agents","volume":"17","author":"Carlson","year":"1985","journal-title":"Agents Actions"},{"key":"2024103109364798100_cit3","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0738-081X(02)00276-6","article-title":"The role of the pharmaceutical industry in drug development in dermatology","volume":"20","author":"Cauwenbergh","year":"2002","journal-title":"Clin Dermatol."},{"key":"2024103109364798100_cit4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0014-2999(85)90061-5","article-title":"Modulation by hydroxyeicosatetraenoic acids (HETEs) of arachidonic acid metabolism in mouse resident peritoneal macrophages","volume":"107","author":"Chang","year":"1985","journal-title":"Eur. 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