{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:13:26Z","timestamp":1762323206464,"version":"3.28.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The purpose of the present study was to evaluate skin-compatible drug delivery systems for fluconazole. Pseudoternary phase diagrams were constructed, composed of different soybean lecithins\/oil\/isopropanol and water. The role of the various lecithin compositions was expressed in the different resulting isotropic areas. Based on these phase diagrams, two systems were chosen as drug delivery systems for fluconazole. The influence of phosphatidylethanolamine and of the oil component on the skin permeation of fluconazole was investigated. The more phosphatidylethanolamine, the greater was the fluconazole skin permeation, independent of the hydrophilicity of the system. The influence of oleic acid and isopropylmyristate as the oil component was compared and a greater penetration enhancing effect was found for the microemulsion containing oleic acid.<\/jats:p>","DOI":"10.1211\/jpp.60.5.0003","type":"journal-article","created":{"date-parts":[[2008,4,7]],"date-time":"2008-04-07T00:38:57Z","timestamp":1207528737000},"page":"587-591","source":"Crossref","is-referenced-by-count":26,"title":["Skin-compatible lecithin drug delivery systems for fluconazole: effect of phosphatidylethanolamine and oleic acid on skin permeation"],"prefix":"10.1093","volume":"60","author":[{"given":"Sonja","family":"Hoeller","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences , Althanstrasse 14, 1090 Vienna,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Klang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences , Althanstrasse 14, 1090 Vienna,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Valenta","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences , Althanstrasse 14, 1090 Vienna,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,5,1]]},"reference":[{"key":"2024103109363479800_cit1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0378-5173(93)90174-E","article-title":"Investigations into the formation and characterization of phospholipid microemulsions. I. Pseudo-ternary phase diagrams of systems containing water-lecithin-alcohol-isopropylmyristate","volume":"93","author":"Aboofazeli","year":"1993","journal-title":"Int. J. Pharm."},{"key":"2024103109363479800_cit2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0378-5173(94)90275-5","article-title":"Investigations into the formation and characterization of phospholipid microemulsions. II. Pseudo-ternary phase diagrams of systems containing water-lecithin-alcohol-isopropylmyristate and alcohol: influence of purity of lecithin","volume":"106","author":"Aboofazeli","year":"1994","journal-title":"Int. J. Pharm."},{"key":"2024103109363479800_cit3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0378-5173(95)00125-3","article-title":"Investigations into the formation and characterization of phospholipid microemulsions. IV. 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