{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:40:34Z","timestamp":1791103234683,"version":"4.1.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Regulation of tissue redox status is important to maintain normal physiological conditions in the living body. Disruption of redox homoeostasis may lead to oxidative stress and can induce many pathological conditions such as cancer, neurological disorders and ageing. Therefore, imaging of tissue redox status could have clinical applications. Redox imaging employing magnetic resonance imaging (MRI) with nitroxides as cell-permeable redox-sensitive contrast agents has been used for non-invasive monitoring of tissue redox status in animal models. The redox imaging applications of nitroxide electron paramagnetic resonance imaging (EPRI) and MRI are reviewed here, with a focus on application of tumour redox status monitoring. While particular emphasis has been placed on differences in the redox status in tumours compared to selected normal tissues, the technique possesses the potential to have broad applications to the study of other disease states, inflammatory processes and other circumstances where oxidative stress is implicated.<\/jats:p>","DOI":"10.1211\/jpp.60.8.0011","type":"journal-article","created":{"date-parts":[[2008,7,11]],"date-time":"2008-07-11T01:47:27Z","timestamp":1215740847000},"page":"1049-1060","source":"Crossref","is-referenced-by-count":78,"title":["Assessment of tissue redox status using metabolic responsive contrast agents and magnetic resonance imaging"],"prefix":"10.1093","volume":"60","author":[{"given":"Fuminori","family":"Hyodo","sequence":"first","affiliation":[{"name":"Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH , Bethesda, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin P","family":"Soule","sequence":"additional","affiliation":[{"name":"Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH , Bethesda, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichiro","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH , Bethesda, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Matusmoto","sequence":"additional","affiliation":[{"name":"Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH , Bethesda, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A","family":"Cook","sequence":"additional","affiliation":[{"name":"Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH , Bethesda, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Hyodo","sequence":"additional","affiliation":[{"name":"Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH , Bethesda, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia L","family":"Sowers","sequence":"additional","affiliation":[{"name":"Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH , Bethesda, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murali C","family":"Krishna","sequence":"additional","affiliation":[{"name":"Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH , Bethesda, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH , Bethesda, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,8,1]]},"reference":[{"key":"2024103109364677800_cit1","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/jmri.1073","article-title":"Methodology of brain perfusion imaging","volume":"13","author":"Barbier","year":"2001","journal-title":"J. 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Sci."},{"key":"2024103109364677800_cit32","first-page":"1562","article-title":"In vivo electron paramagnetic resonance imaging of tumor heterogeneity and oxygenation in a murine model","volume":"58","author":"Kuppusamy","year":"1998","journal-title":"Cancer Res."},{"key":"2024103109364677800_cit33","first-page":"307","article-title":"Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels","volume":"62","author":"Kuppusamy","year":"2002","journal-title":"Cancer Res."},{"key":"2024103109364677800_cit34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0006-8993(95)00413-K","article-title":"Assessment of cerebral pO2 by EPR oximetry in rodents: effects of anesthesia, ischemia, and breathing gas","volume":"685","author":"Liu","year":"1995","journal-title":"Brain Res."},{"key":"2024103109364677800_cit35","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1148\/radiol.2452061117","article-title":"Molecular imaging techniques in body imaging","volume":"245","author":"Margolis","year":"2007","journal-title":"Radiology"},{"key":"2024103109364677800_cit36","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1158\/1078-0432.CCR-05-2747","article-title":"High-resolution mapping of tumor redox status by magnetic resonance imaging using nitroxides as redox-sensitive contrast agents","volume":"12","author":"Matsumoto","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"2024103109364677800_cit37","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jmr.2007.03.013","article-title":"Comparisons of EPR imaging and T1-weighted MRI for efficient imaging of nitroxyl contrast agents","volume":"187","author":"Matsumoto","year":"2007","journal-title":"J. Magn. Reson."},{"issue":"Suppl.","key":"2024103109364677800_cit38","first-page":"96","article-title":"The role of glutathione in radiation and drug induced cytotoxicity","volume":"8","author":"Mitchell","year":"1987","journal-title":"Br. J. Cancer"},{"key":"2024103109364677800_cit39","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/0003-9861(91)90442-L","article-title":"Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, tempol","volume":"289","author":"Mitchell","year":"1991","journal-title":"Arch. Biochem. Biophys."},{"key":"2024103109364677800_cit40","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1749-6632.2000.tb06174.x","article-title":"Radiation, radicals, and images","volume":"899","author":"Mitchell","year":"2000","journal-title":"Ann. NY Acad. Sci."},{"key":"2024103109364677800_cit41","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0891-5849(02)01193-0","article-title":"A low molecular weight antioxidant decreases weight and lowers tumor incidence","volume":"34","author":"Mitchell","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"2024103109364677800_cit42","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1148\/radiol.2393042031","article-title":"Diffusion-weighted and perfusion MR imaging for brain tumor characterization and assessment of treatment response","volume":"239","author":"Provenzale","year":"2006","journal-title":"Radiology"},{"key":"2024103109364677800_cit43","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3109\/10715769009145682","article-title":"Superoxide reaction with nitroxides","volume":"9","author":"Samuni","year":"1990","journal-title":"Free Radic. Res. Commun."},{"key":"2024103109364677800_cit44","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1089\/152308604773934341","article-title":"Factors influencing nitroxide reduction and cytotoxicity in vitro","volume":"6","author":"Samuni","year":"2004","journal-title":"Antioxid. Redox Signal."},{"key":"2024103109364677800_cit45","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0891-5849(01)00480-4","article-title":"Redox environment of the cell as viewed through the redox state of the glutathione disulfide\/glutathione couple","volume":"30","author":"Schafer","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"2024103109364677800_cit46","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1601-0825.2006.01258.x","article-title":"Oral mucositis","volume":"12","author":"Scully","year":"2006","journal-title":"Oral Dis."},{"key":"2024103109364677800_cit47","doi-asserted-by":"crossref","first-page":"10901","DOI":"10.1073\/pnas.0403918101","article-title":"MRI detection of single particles for cellular imaging","volume":"101","author":"Shapiro","year":"2004","journal-title":"Proc. Natl Acad. Sci."},{"key":"2024103109364677800_cit48","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/1522-2594(200008)44:2<169::AID-MRM1>3.0.CO;2-U","article-title":"Imaging blood flow in brain tumors using arterial spin labeling","volume":"44","author":"Silva","year":"2000","journal-title":"Magn. Reson. Med."},{"key":"2024103109364677800_cit49","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1016\/j.freeradbiomed.2007.02.030","article-title":"The chemistry and biology of nitroxide compounds","volume":"42","author":"Soule","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"2024103109364677800_cit50","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/09553009414550121","article-title":"Manipulation and exploitation of the tumour environment for therapeutic benefit","volume":"65","author":"Stratford","year":"1994","journal-title":"Int. J. Radiat. Biol."},{"key":"2024103109364677800_cit51","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/nbm.897","article-title":"Radio frequency continuous-wave and time-domain EPR imaging and Overhauser-enhanced magnetic resonance imaging of small animals: instrumental developments and comparison of relative merits for functional imaging","volume":"17","author":"Subramanian","year":"2004","journal-title":"NMR Biomed."},{"key":"2024103109364677800_cit52","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3109\/10715769009145700","article-title":"Principles of the metabolism of nitroxides and their implications for spin trapping","volume":"9","author":"Swartz","year":"1990","journal-title":"Free Radic. Res. Commun."},{"key":"2024103109364677800_cit53","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0167-4889(86)90073-X","article-title":"Cellular metabolism of water-soluble nitroxides: effect on rate of reduction of cell\/nitroxide ratio, oxygen concentrations and permeability of nitroxides","volume":"888","author":"Swartz","year":"1986","journal-title":"Biochim. Biophys. Acta."},{"key":"2024103109364677800_cit54","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/mrm.1910030126","article-title":"Hypoxia-sensitive NMR contrast agents","volume":"3","author":"Swartz","year":"1986","journal-title":"Magn. Reson. Med."},{"key":"2024103109364677800_cit55","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3322\/canjclin.57.4.206","article-title":"Functional imaging of cancer with emphasis on molecular techniques","volume":"57","author":"Torigian","year":"2007","journal-title":"CA Cancer J. Clin."},{"key":"2024103109364677800_cit56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0003-9861(03)00285-6","article-title":"In vivo electron spin resonance-computed tomography\/nitroxyl probe technique for non-invasive analysis of oxidative injuries","volume":"416","author":"Utsumi","year":"2003","journal-title":"Arch. Biochem. 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