{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T17:45:33Z","timestamp":1778089533813,"version":"3.51.4"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Cefodizime is a broad spectrum cephalosporin belonging to the third generation agents. In this study, attention has been paid to the preparation, physicochemical characterization and biological evaluation of new Cu2+, Zn2+, Fe3+, Co2+ and Al3+ complexes of cefodizime.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The stoichiometrics and the mode of bonding of the complexes were deduced from their elemental and metal analysis, electrical conductivity measurements, UV-vis, infrared and Raman spectroscopic investigations. Study of the stoichiometry of these complexes referred to the formation of 1: 1 ratios of metal to ligand. Antimicrobial activity of the complexes was determined using two strains of Gram-positive (Bacillus subtilis and Proteus vulgaris) and two strains of Gram-negative (Escherichia coli W3110 and Pseudomonas putida) bacteria. The minimal inhibitory concentration was determined as the lowest concentration inhibiting bacterial growth on solid Luria Bertani medium.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>The spectra gave evidence as to the position of binding. In addition, the aqueous solubility of cefodizime was strongly reduced by complexation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The antibacterial activity of cefodizime was not affected by complexation with Al3+ but it was reduced by complexation with the other tested metal ions against the bacteria under study.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1211\/jpp.61.06.0007","type":"journal-article","created":{"date-parts":[[2009,6,9]],"date-time":"2009-06-09T01:15:41Z","timestamp":1244510141000},"page":"753-758","source":"Crossref","is-referenced-by-count":9,"title":["Preparation, physicochemical characterization and biological evaluation of cefodizime metal ion complexes"],"prefix":"10.1093","volume":"61","author":[{"given":"Sayed H","family":"Auda","sequence":"first","affiliation":[{"name":"Institutes of Pharmacy, Martin-Luther-University Halle-Wittenberg, Halle (Saale) ,","place":["Germany"]},{"name":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch , Assiut,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yahya","family":"Mrestani","sequence":"additional","affiliation":[{"name":"Institutes of Applied Dermatopharmacy, Martin-Luther-University Halle-Wittenberg, Halle (Saale) ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietrich H","family":"Nies","sequence":"additional","affiliation":[{"name":"Institutes of Biology, Martin-Luther-University Halle-Wittenberg, Halle (Saale) ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Gro\u03b2e","sequence":"additional","affiliation":[{"name":"Institutes of Biology, Martin-Luther-University Halle-Wittenberg, Halle (Saale) ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard H H","family":"Neubert","sequence":"additional","affiliation":[{"name":"Institutes of Pharmacy, Martin-Luther-University Halle-Wittenberg, Halle (Saale) ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,6,1]]},"reference":[{"key":"2024103109370432500_cit1","first-page":"167","volume-title":"Martindale. 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