{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:20:49Z","timestamp":1765545649195,"version":"3.28.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>It was found that total flavonoids from Litsea coreana Levl. (TFLC), which is a traditional Chinese medicine, had a preventive effect against hepatic steatosis in our previous study. This study was designed to evaluate whether TFLC could improve liver fibrosis in rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The liver fibrosis model rats were treated with composite factors of high-fat emulsion (10 ml\/kg) via gavage accompanied by a subcutaneous injection of low-dose CCl4. Thirty rats were given composite factors plus TFLC (100, 200, 400 mg\/kg), respectively, for 8 weeks.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>The results showed that TFLC (200 and 400 mg\/kg) treatment significantly reduced the elevation of liver index (liver weight\/body weight) and spleen index (spleen weight\/body weight), alanine transaminase, aspartate aminotransferase, hyaluronic acid, laminin, procollagen III N-terminal peptide, procollagenase IV and hydroxyproline. In addition, TFLC treatment improved the morphologic changes of hepatic fibrosis, suppressed expression of \u03b1-smooth muscle actin, collagen I, transforming growth factor (TGF)-\u03b21 and TGF\u03b2 receptor (TGF\u03b2R)1, and increased peroxisome proliferator-activated receptor-\u03b3 expression in the liver of hepatic fibrosis rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In conclusion, TFLC is able to ameliorate liver injury and protect rats from liver fibrosis. This process may be related to inhibiting the expression of transforming growth factor-\u03b21 and increasing the expression of peroxisome proliferator-activated receptor-\u03b3.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1211\/jpp.62.02.0010","type":"journal-article","created":{"date-parts":[[2010,10,14]],"date-time":"2010-10-14T12:01:59Z","timestamp":1287057719000},"page":"223-230","source":"Crossref","is-referenced-by-count":27,"title":["Potential protective effects of a traditional Chinese herb, <i>Litsea coreana<\/i> Levl., on liver fibrosis in rats"],"prefix":"10.1093","volume":"62","author":[{"given":"Cheng","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Anhui Medical University , Hefei, Hong Kong,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taotao","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Anhui Medical University , Hefei, Hong Kong,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Hong Kong , Hong Kong,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiongwen","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Anhui Medical University , Hefei, Hong Kong,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Anhui Medical University , Hefei, Hong Kong,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Anhui Medical University , Hefei, Hong 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