{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T15:53:45Z","timestamp":1770134025530,"version":"3.49.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Increased production and accumulation of melanin leads to many hyperpigmentation disorders such as melasma, freckles and geriatric pigment spots. Thus, there is a need for the development of depigmenting agents. Based on our previous reports, selenium derivatives as anti-melanogenic lead compounds could be very important. The aim of this study was to investigate the depigmenting effect of novel selenium-containing compounds.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The inhibitory effects of 5-chloroacetyl-2-piperidino-1,3-selenazole (CS1), a novel selenium-containing compound, on melanogenesis were investigated in B16F10 melanoma cells and cultured brownish guinea pig skin tissue with \u03b1-melanocyte-stimulating hormone stimulation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>We found that CS1 inhibited melanin production in B16F10 cells by suppressing tyrosinase activity and its protein expression. In addition, Western blotting analysis revealed that CS1 suppressed the expression of tyrosinase-related protein (TRP)-1 and TRP-2. Therefore, the depigmenting effect of CS1 might have been due to inhibition of tyrosinase activity and expression of melanogenic enzymes. Furthermore, CS1 had inhibitory effects on melanin biosynthesis of primary cultured skin of brownish guinea pig.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The results suggested that CS1 could be a useful candidate for the treatment of skin hyperpigmentation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1211\/jpp.62.03.0010","type":"journal-article","created":{"date-parts":[[2010,10,14]],"date-time":"2010-10-14T12:26:11Z","timestamp":1287059171000},"page":"352-359","source":"Crossref","is-referenced-by-count":23,"title":["Inhibitory effects of 5-chloroacetyl-2-piperidino-1,3-selenazole, a novel selenium-containing compound, on skin melanin biosynthesis"],"prefix":"10.1093","volume":"62","author":[{"given":"Eunjoo H","family":"Lee","sequence":"first","affiliation":[{"name":"Graduate School of East-West Medical Science ,","place":["Japan"]},{"name":"East-West Integrated Medical Science Research Center ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Ji","family":"Lim","sequence":"additional","affiliation":[{"name":"Graduate School of East-West Medical Science ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Keun","family":"Ha","sequence":"additional","affiliation":[{"name":"Graduate School of East-West Medical Science ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong Ho","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Oriental Medicinal Material & Processing, College of Life Science ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Koketsu","sequence":"additional","affiliation":[{"name":"Division of Instrumental Analysis, Life Science Research Center, Gifu University , Gifu,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chulhun","family":"Kang","sequence":"additional","affiliation":[{"name":"Graduate School of East-West Medical Science ,","place":["Japan"]},{"name":"East-West Integrated Medical Science Research Center ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Yeou","family":"Kim","sequence":"additional","affiliation":[{"name":"Graduate School of East-West Medical Science ,","place":["Japan"]},{"name":"East-West Integrated Medical Science Research Center ,","place":["Japan"]},{"name":"Skin Biotechnology Research Center, Kyung Hee University , Yongin-si, Gyeonggi-do,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Graduate School of East-West Medical Science ,","place":["Japan"]},{"name":"East-West Integrated Medical Science Research Center 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