{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:53:58Z","timestamp":1791017638457,"version":"4.1.0"},"reference-count":86,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Historically, the majority of new drugs have been generated from natural products as well as from compounds derived from natural products. In this context, Mikania laevigata and M. glomerata, popularly known as \u2018guaco\u2019, have a long history of use. Brazilian Indians have an ancient tradition of using \u2018guaco\u2019 for snakebites. In current herbal medicine in Brazil, \u2018guaco\u2019 is used as an effective natural bronchodilator, expectorant and cough suppressant employed for all types of upper respiratory problems including bronchitis, pleurisy, colds and flu, coughs and asthma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>In Brazil, this plant has been widely used, even as commercial preparations. Its medicinal properties are widely recognized, mainly in the treatment of inflammatory conditions, bronchodilator activity, anti-ulcerogenic, antiophidian as well as antibacterial and antiparasitic activity, although the efficacy of the antibacterial activity is so far controversial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>The studies on Mikania glomerata and M. laevigata have provided scientific evidence that those plants have a considerable anti-inflammatory therapeutic potential.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1211\/jpp.62.07.0001","type":"journal-article","created":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T20:54:24Z","timestamp":1441313664000},"page":"809-820","source":"Crossref","is-referenced-by-count":34,"title":["Scientific evidence for <i>Mikania laevigata<\/i> and <i>Mikania glomerata<\/i> as a pharmacological tool"],"prefix":"10.1093","volume":"62","author":[{"given":"Marcelo H","family":"Napimoga","sequence":"first","affiliation":[{"name":"Laboratory of Biopathology and Molecular Biology, University of Uberaba ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regiane","family":"Yatsuda","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology and Pharmacology, Federal University of Bahia ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,7,1]]},"reference":[{"key":"2024103013100882000_cit1","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1590\/S0074-02762002000700017","article-title":"Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases","volume":"97","author":"Holetz","year":"2002","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"2024103013100882000_cit2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.hoc.2008.04.007","article-title":"Evidence-based botanical research: applications and challenges","volume":"22","author":"Yeung","year":"2008","journal-title":"Hematol Oncol Clin North Am"},{"key":"2024103013100882000_cit3","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.drudis.2008.07.004","article-title":"Natural products in drug discovery","volume":"13","author":"Harvey","year":"2008","journal-title":"Drug Discov Today"},{"key":"2024103013100882000_cit4","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1021\/np068054v","article-title":"Natural products as sources of new drugs over the last 25 years","volume":"70","author":"Newman","year":"2007","journal-title":"J Nat Prod"},{"key":"2024103013100882000_cit5","doi-asserted-by":"crossref","DOI":"10.5962\/bhl.title.156613","volume-title":"The Genera of the Eupatorieae (Asteraceae)","author":"King","year":"1987"},{"key":"2024103013100882000_cit6","first-page":"239","volume-title":"A Review Preparatory to an Infrageneric Classification of Mikania (Tribe: Eupatorieae)","author":"Holmes","year":"1995"},{"key":"2024103013100882000_cit7","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1590\/S0102-33062004000300021","article-title":"Biogeografia do g\u00eanero Mikania Willd. 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