{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:02:38Z","timestamp":1770739358029,"version":"3.49.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.neurology.org"],"crossmark-restriction":true},"short-container-title":["Neurology Open Access"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1212\/wn9.0000000000000058","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T21:00:22Z","timestamp":1770670822000},"update-policy":"https:\/\/doi.org\/10.1212\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["A Tale of Monozygotic Twins With Down Syndrome: Divergent Clinical Paths to Dementia"],"prefix":"10.1212","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6563-0950","authenticated-orcid":false,"given":"Giovi G.","family":"Hersch","sequence":"first","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Leka","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianna Eloise","family":"Acosta","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2832-9214","authenticated-orcid":false,"given":"Laura","family":"Xicota","sequence":"additional","affiliation":[{"name":"Gertrude. H. Sergievsky Center, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University Irving Medical Center, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2000-4821","authenticated-orcid":false,"given":"Joseph H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Gertrude. H. Sergievsky Center, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University Irving Medical Center, New York;"},{"name":"Department of Epidemiology, Columbia University Irving Medical Center, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3160-4846","authenticated-orcid":false,"given":"Margaret B.","family":"Pulsifer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christy L.","family":"Hom","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior, University of California, Irvine School of Medicine, Irvine, CA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9419-0527","authenticated-orcid":false,"given":"Florence","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9360-7511","authenticated-orcid":false,"given":"Herminia Diana","family":"Rosas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20735"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410170310"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12065"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-017-9341-9"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2788.2002.00417.x"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00245-3"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-019-0477-0"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.6117"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500398102"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006617"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0013-y"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2013.12.001"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32475-x"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes14020347"}],"container-title":["Neurology Open Access"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.neurology.org\/doi\/pdfdirect\/10.1212\/WN9.0000000000000058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T21:00:32Z","timestamp":1770670832000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.neurology.org\/doi\/10.1212\/WN9.0000000000000058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1212\/WN9.0000000000000058"],"URL":"https:\/\/doi.org\/10.1212\/wn9.0000000000000058","relation":{},"ISSN":["2998-7601"],"issn-type":[{"value":"2998-7601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e000058"}}