{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:26:57Z","timestamp":1791685617851,"version":"4.3.4"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["neurology.org"],"crossmark-restriction":true},"short-container-title":["Neurology"],"published-print":{"date-parts":[[2010,3,23]]},"DOI":"10.1212\/wnl.0b013e3181d6476a","type":"journal-article","created":{"date-parts":[[2010,3,3]],"date-time":"2010-03-03T22:44:56Z","timestamp":1267656296000},"page":"956-964","update-policy":"https:\/\/doi.org\/10.1212\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":355,"title":["Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease"],"prefix":"10.1212","volume":"74","author":[{"given":"H. H.","family":"Feldman","sequence":"first","affiliation":[{"name":"From the Division of Neurology (H.H.F.), University of British Columbia, UBCH Clinic for Alzheimer's Disease and Related Disorders, Vancouver, Canada; Department of Neurology (R.S.D.), Baylor College of Medicine, Houston, TX; Aging Research Center (M.K.), Karolinska Institutet, Stockholm, Sweden; Ralph &amp; Muriel Roberts Laboratory For Neurodegenerative Research (D.L.S.), Sun Health Research Institute, Sun City, AZ; San Francisco General Hospital (D.D.W.), San Francisco, CA; RICE (The Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. S.","family":"Doody","sequence":"additional","affiliation":[{"name":"From the Division of Neurology (H.H.F.), University of British Columbia, UBCH Clinic for Alzheimer's Disease and Related Disorders, Vancouver, Canada; Department of Neurology (R.S.D.), Baylor College of Medicine, Houston, TX; Aging Research Center (M.K.), Karolinska Institutet, Stockholm, Sweden; Ralph &amp; Muriel Roberts Laboratory For Neurodegenerative Research (D.L.S.), Sun Health Research Institute, Sun City, AZ; San Francisco General Hospital (D.D.W.), San Francisco, CA; RICE (The Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kivipelto","sequence":"additional","affiliation":[{"name":"From the Division of Neurology (H.H.F.), University of British Columbia, UBCH Clinic for Alzheimer's Disease and Related Disorders, Vancouver, Canada; Department of Neurology (R.S.D.), Baylor College of Medicine, Houston, TX; Aging Research Center (M.K.), Karolinska Institutet, Stockholm, Sweden; Ralph &amp; Muriel Roberts Laboratory For Neurodegenerative Research (D.L.S.), Sun Health Research Institute, Sun City, AZ; San Francisco General Hospital (D.D.W.), San Francisco, CA; RICE (The Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. L.","family":"Sparks","sequence":"additional","affiliation":[{"name":"From the Division of Neurology (H.H.F.), University of British Columbia, UBCH Clinic for Alzheimer's Disease and Related Disorders, Vancouver, Canada; Department of Neurology (R.S.D.), Baylor College of Medicine, Houston, TX; Aging Research Center (M.K.), Karolinska Institutet, Stockholm, Sweden; Ralph &amp; Muriel Roberts Laboratory For Neurodegenerative Research (D.L.S.), Sun Health Research Institute, Sun City, AZ; San Francisco General Hospital (D.D.W.), San Francisco, CA; RICE (The Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. D.","family":"Waters","sequence":"additional","affiliation":[{"name":"From the Division of Neurology (H.H.F.), University of British Columbia, UBCH Clinic for Alzheimer's Disease and Related Disorders, Vancouver, Canada; Department of Neurology (R.S.D.), Baylor College of Medicine, Houston, TX; Aging Research Center (M.K.), Karolinska Institutet, Stockholm, Sweden; Ralph &amp; Muriel Roberts Laboratory For Neurodegenerative Research (D.L.S.), Sun Health Research Institute, Sun City, AZ; San Francisco General Hospital (D.D.W.), San Francisco, CA; RICE (The Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. W.","family":"Jones","sequence":"additional","affiliation":[{"name":"From the Division of Neurology (H.H.F.), University of British Columbia, UBCH Clinic for Alzheimer's Disease and Related Disorders, Vancouver, Canada; Department of Neurology (R.S.D.), Baylor College of Medicine, Houston, TX; Aging Research Center (M.K.), Karolinska Institutet, Stockholm, Sweden; Ralph &amp; Muriel Roberts Laboratory For Neurodegenerative Research (D.L.S.), Sun Health Research Institute, Sun City, AZ; San Francisco General Hospital (D.D.W.), San Francisco, CA; RICE (The Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Schwam","sequence":"additional","affiliation":[{"name":"From the Division of Neurology (H.H.F.), University of British Columbia, UBCH Clinic for Alzheimer's Disease and Related Disorders, Vancouver, Canada; Department of Neurology (R.S.D.), Baylor College of Medicine, Houston, TX; Aging Research Center (M.K.), Karolinska Institutet, Stockholm, Sweden; Ralph &amp; Muriel Roberts Laboratory For Neurodegenerative Research (D.L.S.), Sun Health Research Institute, Sun City, AZ; San Francisco General Hospital (D.D.W.), San Francisco, CA; RICE (The Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Schindler","sequence":"additional","affiliation":[{"name":"From the Division of Neurology (H.H.F.), University of British Columbia, UBCH Clinic for Alzheimer's Disease and Related Disorders, Vancouver, Canada; Department of Neurology (R.S.D.), Baylor College of Medicine, Houston, TX; Aging Research Center (M.K.), Karolinska Institutet, Stockholm, Sweden; Ralph &amp; Muriel Roberts Laboratory For Neurodegenerative Research (D.L.S.), Sun Health Research Institute, Sun City, AZ; San Francisco General Hospital (D.D.W.), San Francisco, CA; RICE (The Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hey-Hadavi","sequence":"additional","affiliation":[{"name":"From the Division of Neurology (H.H.F.), University of British Columbia, UBCH Clinic for Alzheimer's Disease and Related Disorders, Vancouver, Canada; Department of Neurology (R.S.D.), Baylor College of Medicine, Houston, TX; Aging Research Center (M.K.), Karolinska Institutet, Stockholm, Sweden; Ralph &amp; Muriel Roberts Laboratory For Neurodegenerative Research (D.L.S.), Sun Health Research Institute, Sun City, AZ; San Francisco General Hospital (D.D.W.), San Francisco, CA; RICE (The Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"DeMicco","sequence":"additional","affiliation":[{"name":"From the Division of Neurology (H.H.F.), University of British Columbia, UBCH Clinic for Alzheimer's Disease and Related Disorders, Vancouver, Canada; Department of Neurology (R.S.D.), Baylor College of Medicine, Houston, TX; Aging Research Center (M.K.), Karolinska Institutet, Stockholm, Sweden; Ralph &amp; Muriel Roberts Laboratory For Neurodegenerative Research (D.L.S.), Sun Health Research Institute, Sun City, AZ; San Francisco General Hospital (D.D.W.), San Francisco, CA; RICE (The Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Breazna","sequence":"additional","affiliation":[{"name":"From the Division of Neurology (H.H.F.), University of British Columbia, UBCH Clinic for Alzheimer's Disease and Related Disorders, Vancouver, Canada; Department of Neurology (R.S.D.), Baylor College of Medicine, Houston, TX; Aging Research Center (M.K.), Karolinska Institutet, Stockholm, Sweden; Ralph &amp; Muriel Roberts Laboratory For Neurodegenerative Research (D.L.S.), Sun Health Research Institute, Sun City, AZ; San Francisco General Hospital (D.D.W.), San Francisco, CA; RICE (The Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113.11.1857"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70248-9"},{"key":"e_1_3_3_4_2","first-page":"63","volume":"185","year":"2006","unstructured":"Wolozin B, Manger J, Bryant R, Cordy J, Green RC, McKee A. Re-assessing the relationship between cholesterol, statins and Alzheimer's disease. Acta Neurol Scand Suppl 2006;185:63\u201370.","journal-title":"Acta Neurol Scand Suppl"},{"key":"e_1_3_3_5_2","first-page":"254","volume":"21","year":"2000","unstructured":"Austen B, Frears E, Davies H. Cholesterol upregulates production of A[beta] 1-40 and 1-42 in transfected cells. Neurobiol Aging 2000;21:254.","journal-title":"Neurobiol Aging"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.8.4436"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.26.16576"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6460"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(90)90024-T"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.081620098"},{"key":"e_1_3_3_11_2","first-page":"87","volume":"185","year":"2006","unstructured":"Hoglund K, Wallin A, Blennow K. Effect of statins on beta-amyloid metabolism in humans: potential importance for the development of senile plaques in Alzheimer's disease. Acta Neurol Scand Suppl 2006;185:87\u201392.","journal-title":"Acta Neurol Scand Suppl"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03155-X"},{"key":"e_1_3_3_13_2","doi-asserted-by":"crossref","unstructured":"Wolozin B Wang SW Li NC Lee A Lee TA Kazis LE. Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease. BMC Med 2007;5:20.","DOI":"10.1186\/1741-7015-5-20"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000288181.00826.63"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.150433"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09327-3"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11600-X"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.5.753"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.23.3043"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2008.02.001"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1109\/42.668698"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410070516"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.141.11.1356"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-199700112-00004"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.12.2308"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-199700112-00003"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.3.481"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1109\/42.640753"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000133317.49796.0E"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540340047031"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70178-3"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050461"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061894"},{"key":"e_1_3_3_37_2","unstructured":"US Prescribing Information: Lipitor\u00ae (atorvastatin calcium) tablets. New York NY: Pfizer Inc.; November 2007."},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.26.8.1190"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.23.15.1663.31953"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1080\/10543400802609797"}],"container-title":["Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.neurology.org\/doi\/pdfdirect\/10.1212\/WNL.0b013e3181d6476a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T09:00:11Z","timestamp":1711616411000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.neurology.org\/doi\/10.1212\/WNL.0b013e3181d6476a"}},"subtitle":["LEADe"],"short-title":[],"issued":{"date-parts":[[2010,3,23]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,3,23]]}},"alternative-id":["10.1212\/WNL.0b013e3181d6476a"],"URL":"https:\/\/doi.org\/10.1212\/wnl.0b013e3181d6476a","relation":{},"ISSN":["0028-3878","1526-632X"],"issn-type":[{"value":"0028-3878","type":"print"},{"value":"1526-632X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,23]]}}}