{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:59:43Z","timestamp":1789736383559,"version":"4.0.1"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["neurology.org"],"crossmark-restriction":true},"short-container-title":["Neurology"],"published-print":{"date-parts":[[1993,5]]},"DOI":"10.1212\/wnl.43.5.910","type":"journal-article","created":{"date-parts":[[2012,5,13]],"date-time":"2012-05-13T13:07:54Z","timestamp":1336914474000},"page":"910-910","update-policy":"https:\/\/doi.org\/10.1212\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":198,"title":["Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis"],"prefix":"10.1212","volume":"43","author":[{"given":"H. L.","family":"Weiner","sequence":"first","affiliation":[{"name":"Multiple Sclerosis Unit of the Center for Neurologic Diseases, Division of Neurology, Department of Medicine (Drs. Weiner, Hafler, Mackin, and Dawson), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard School of Public Health (Dr. Orav), Boston, MA; Montreal Neurologic Institute (Dr. LaPierre), Montreal, PQ, Canada; Massachusetts General Hospital (Drs. Lehrich and Hauser), Boston, MA; Strong Memorial Hospital (Dr. Herndon), Rochester, NY;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. A.","family":"Mackin","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Unit of the Center for Neurologic Diseases, Division of Neurology, Department of Medicine (Drs. Weiner, Hafler, Mackin, and Dawson), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard School of Public Health (Dr. Orav), Boston, MA; Montreal Neurologic Institute (Dr. LaPierre), Montreal, PQ, Canada; Massachusetts General Hospital (Drs. Lehrich and Hauser), Boston, MA; Strong Memorial Hospital (Dr. Herndon), Rochester, NY;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. J.","family":"Orav","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Unit of the Center for Neurologic Diseases, Division of Neurology, Department of Medicine (Drs. Weiner, Hafler, Mackin, and Dawson), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard School of Public Health (Dr. Orav), Boston, MA; Montreal Neurologic Institute (Dr. LaPierre), Montreal, PQ, Canada; Massachusetts General Hospital (Drs. Lehrich and Hauser), Boston, MA; Strong Memorial Hospital (Dr. Herndon), Rochester, NY;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"Hafler","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Unit of the Center for Neurologic Diseases, Division of Neurology, Department of Medicine (Drs. Weiner, Hafler, Mackin, and Dawson), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard School of Public Health (Dr. Orav), Boston, MA; Montreal Neurologic Institute (Dr. LaPierre), Montreal, PQ, Canada; Massachusetts General Hospital (Drs. Lehrich and Hauser), Boston, MA; Strong Memorial Hospital (Dr. Herndon), Rochester, NY;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Dawson","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Unit of the Center for Neurologic Diseases, Division of Neurology, Department of Medicine (Drs. Weiner, Hafler, Mackin, and Dawson), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard School of Public Health (Dr. Orav), Boston, MA; Montreal Neurologic Institute (Dr. LaPierre), Montreal, PQ, Canada; Massachusetts General Hospital (Drs. Lehrich and Hauser), Boston, MA; Strong Memorial Hospital (Dr. Herndon), Rochester, NY;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"LaPierre","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Unit of the Center for Neurologic Diseases, Division of Neurology, Department of Medicine (Drs. Weiner, Hafler, Mackin, and Dawson), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard School of Public Health (Dr. Orav), Boston, MA; Montreal Neurologic Institute (Dr. LaPierre), Montreal, PQ, Canada; Massachusetts General Hospital (Drs. Lehrich and Hauser), Boston, MA; Strong Memorial Hospital (Dr. Herndon), Rochester, NY;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Herndon","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Unit of the Center for Neurologic Diseases, Division of Neurology, Department of Medicine (Drs. Weiner, Hafler, Mackin, and Dawson), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard School of Public Health (Dr. Orav), Boston, MA; Montreal Neurologic Institute (Dr. LaPierre), Montreal, PQ, Canada; Massachusetts General Hospital (Drs. Lehrich and Hauser), Boston, MA; Strong Memorial Hospital (Dr. Herndon), Rochester, NY;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"Lehrich","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Unit of the Center for Neurologic Diseases, Division of Neurology, Department of Medicine (Drs. Weiner, Hafler, Mackin, and Dawson), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard School of Public Health (Dr. Orav), Boston, MA; Montreal Neurologic Institute (Dr. LaPierre), Montreal, PQ, Canada; Massachusetts General Hospital (Drs. Lehrich and Hauser), Boston, MA; Strong Memorial Hospital (Dr. Herndon), Rochester, NY;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. L.","family":"Hauser","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Unit of the Center for Neurologic Diseases, Division of Neurology, Department of Medicine (Drs. Weiner, Hafler, Mackin, and Dawson), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard School of Public Health (Dr. Orav), Boston, MA; Montreal Neurologic Institute (Dr. LaPierre), Montreal, PQ, Canada; Massachusetts General Hospital (Drs. Lehrich and Hauser), Boston, MA; Strong Memorial Hospital (Dr. Herndon), Rochester, NY;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Turel","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Unit of the Center for Neurologic Diseases, Division of Neurology, Department of Medicine (Drs. Weiner, Hafler, Mackin, and Dawson), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard School of Public Health (Dr. Orav), Boston, MA; Montreal Neurologic Institute (Dr. LaPierre), Montreal, PQ, Canada; Massachusetts General Hospital (Drs. Lehrich and Hauser), Boston, MA; Strong Memorial Hospital (Dr. Herndon), Rochester, NY;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Unit of the Center for Neurologic Diseases, Division of Neurology, Department of Medicine (Drs. Weiner, Hafler, Mackin, and Dawson), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard School of Public Health (Dr. Orav), Boston, MA; Montreal Neurologic Institute (Dr. LaPierre), Montreal, PQ, Canada; Massachusetts General Hospital (Drs. Lehrich and Hauser), Boston, MA; Strong Memorial Hospital (Dr. Herndon), Rochester, NY;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Birnbaum","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Unit of the Center for Neurologic Diseases, Division of Neurology, Department of Medicine (Drs. Weiner, Hafler, Mackin, and Dawson), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard School of Public Health (Dr. Orav), Boston, MA; Montreal Neurologic Institute (Dr. LaPierre), Montreal, PQ, Canada; Massachusetts General Hospital (Drs. Lehrich and Hauser), Boston, MA; Strong Memorial Hospital (Dr. Herndon), Rochester, NY;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"McArthur","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Unit of the Center for Neurologic Diseases, Division of Neurology, Department of Medicine (Drs. Weiner, Hafler, Mackin, and Dawson), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard School of Public Health (Dr. Orav), Boston, MA; Montreal Neurologic Institute (Dr. LaPierre), Montreal, PQ, Canada; Massachusetts General Hospital (Drs. Lehrich and Hauser), Boston, MA; Strong Memorial Hospital (Dr. Herndon), Rochester, NY;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Butler","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Unit of the Center for Neurologic Diseases, Division of Neurology, Department of Medicine (Drs. Weiner, Hafler, Mackin, and Dawson), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard School of Public Health (Dr. Orav), Boston, MA; Montreal Neurologic Institute (Dr. LaPierre), Montreal, PQ, Canada; Massachusetts General Hospital (Drs. Lehrich and Hauser), Boston, MA; Strong Memorial Hospital (Dr. Herndon), Rochester, NY;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Moore","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Unit of the Center for Neurologic Diseases, Division of Neurology, Department of Medicine (Drs. Weiner, Hafler, Mackin, and Dawson), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard School of Public Health (Dr. Orav), Boston, MA; Montreal Neurologic Institute (Dr. LaPierre), Montreal, PQ, Canada; Massachusetts General Hospital (Drs. Lehrich and Hauser), Boston, MA; Strong Memorial Hospital (Dr. Herndon), Rochester, NY;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Sigsbee","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Unit of the Center for Neurologic Diseases, Division of Neurology, Department of Medicine (Drs. Weiner, Hafler, Mackin, and Dawson), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard School of Public Health (Dr. Orav), Boston, MA; Montreal Neurologic Institute (Dr. LaPierre), Montreal, PQ, Canada; Massachusetts General Hospital (Drs. Lehrich and Hauser), Boston, MA; Strong Memorial Hospital (Dr. Herndon), Rochester, NY;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Safran","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Unit of the Center for Neurologic Diseases, Division of Neurology, Department of Medicine (Drs. Weiner, Hafler, Mackin, and Dawson), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard School of Public Health (Dr. Orav), Boston, MA; Montreal Neurologic Institute (Dr. LaPierre), Montreal, PQ, Canada; Massachusetts General Hospital (Drs. Lehrich and Hauser), Boston, MA; Strong Memorial Hospital (Dr. Herndon), Rochester, NY;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Northeast Cooperative Multiple Sclerosis Treatment Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.neurology.org\/doi\/pdfdirect\/10.1212\/WNL.43.5.910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T17:00:09Z","timestamp":1711645209000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.neurology.org\/doi\/10.1212\/WNL.43.5.910"}},"subtitle":["Final report of the Northeast Cooperative Multiple Sclerosis Treatment Group"],"short-title":[],"issued":{"date-parts":[[1993,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,5]]}},"alternative-id":["10.1212\/WNL.43.5.910"],"URL":"https:\/\/doi.org\/10.1212\/wnl.43.5.910","relation":{},"ISSN":["0028-3878","1526-632X"],"issn-type":[{"value":"0028-3878","type":"print"},{"value":"1526-632X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,5]]}}}