{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:00:40Z","timestamp":1792425640374,"version":"4.5.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology"],"published-print":{"date-parts":[[1997,10]]},"DOI":"10.1212\/wnl.49.4.1026","type":"journal-article","created":{"date-parts":[[2012,5,13]],"date-time":"2012-05-13T13:30:13Z","timestamp":1336915813000},"page":"1026-1030","source":"Crossref","is-referenced-by-count":152,"title":["Autoantibodies to glutamic acid decarboxylase in three patients with cerebellar ataxia, late-onset insulin-dependent diabetes mellitus, and polyendocrine autoimmunity"],"prefix":"10.1212","volume":"49","author":[{"given":"A.","family":"Saiz","sequence":"first","affiliation":[{"name":"From the Neurology Service (Drs. Saiz, Tolosa, and Graus), Department of Medicine, and Laboratory of Hormonal (Dr. Casamitjana), Hospital Clinic i Provincial, University of Barcelona, Barcelona; Neurology Services (Dr. Arpa), Hospital La Paz, Madrid; and Hospital de Cruces (Drs. Sagasta and Zarranz), Barakaldo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Arpa","sequence":"additional","affiliation":[{"name":"From the Neurology Service (Drs. Saiz, Tolosa, and Graus), Department of Medicine, and Laboratory of Hormonal (Dr. Casamitjana), Hospital Clinic i Provincial, University of Barcelona, Barcelona; Neurology Services (Dr. Arpa), Hospital La Paz, Madrid; and Hospital de Cruces (Drs. Sagasta and Zarranz), Barakaldo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sagasta","sequence":"additional","affiliation":[{"name":"From the Neurology Service (Drs. Saiz, Tolosa, and Graus), Department of Medicine, and Laboratory of Hormonal (Dr. Casamitjana), Hospital Clinic i Provincial, University of Barcelona, Barcelona; Neurology Services (Dr. Arpa), Hospital La Paz, Madrid; and Hospital de Cruces (Drs. Sagasta and Zarranz), Barakaldo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Casamitjana","sequence":"additional","affiliation":[{"name":"From the Neurology Service (Drs. Saiz, Tolosa, and Graus), Department of Medicine, and Laboratory of Hormonal (Dr. Casamitjana), Hospital Clinic i Provincial, University of Barcelona, Barcelona; Neurology Services (Dr. Arpa), Hospital La Paz, Madrid; and Hospital de Cruces (Drs. Sagasta and Zarranz), Barakaldo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Zarranz","sequence":"additional","affiliation":[{"name":"From the Neurology Service (Drs. Saiz, Tolosa, and Graus), Department of Medicine, and Laboratory of Hormonal (Dr. Casamitjana), Hospital Clinic i Provincial, University of Barcelona, Barcelona; Neurology Services (Dr. Arpa), Hospital La Paz, Madrid; and Hospital de Cruces (Drs. Sagasta and Zarranz), Barakaldo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Tolosa","sequence":"additional","affiliation":[{"name":"From the Neurology Service (Drs. Saiz, Tolosa, and Graus), Department of Medicine, and Laboratory of Hormonal (Dr. Casamitjana), Hospital Clinic i Provincial, University of Barcelona, Barcelona; Neurology Services (Dr. Arpa), Hospital La Paz, Madrid; and Hospital de Cruces (Drs. Sagasta and Zarranz), Barakaldo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Graus","sequence":"additional","affiliation":[{"name":"From the Neurology Service (Drs. Saiz, Tolosa, and Graus), Department of Medicine, and Laboratory of Hormonal (Dr. Casamitjana), Hospital Clinic i Provincial, University of Barcelona, Barcelona; Neurology Services (Dr. Arpa), Hospital La Paz, Madrid; and Hospital de Cruces (Drs. Sagasta and Zarranz), Barakaldo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198801073180101"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199001043220101"},{"key":"e_1_3_1_4_2","first-page":"1","volume":"347","year":"1990","unstructured":"Baekkeskov S, Aanstoot Hj, Christgau S, et al. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 1990;347:151-156.","journal-title":"Nature"},{"key":"e_1_3_1_5_2","first-page":"4","volume":"14","year":"1991","unstructured":"Solimena M, De Camilli P. Autoimmunity to glutamic acid decarboxylase (GAD) in stiff-man syndrome and insulin-dependent diabetes mellitus. Trends Neurosci 1991;14:452-457.","journal-title":"Trends Neurosci"},{"key":"e_1_3_1_6_2","first-page":"6","volume":"64","year":"1989","unstructured":"Lorish TR, Thorsteinsson G, Howard FM. Stiff-man syndrome updated. Mayo Clin Proc 1989;64:629-636.","journal-title":"Mayo Clin Proc"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.1.5"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.156.1.8"},{"key":"e_1_3_1_9_2","unstructured":"Solimena M Piccolo G Martino G et al. Autoantibodies directed against gabaergic nerve terminals in a patient with idiopathic late-onset cerebellar ataxia and type IB diabetes mellitus [abstract]. Clin Neuropathol 1988;7(suppl):211."},{"key":"e_1_3_1_10_2","unstructured":"Grimaldi LME Quattrini A Martino G et al. Cerebellar autoantibodies in patients with isolated or associated stiff-man syndrome and cerebellar atrophies [abstract]. Neurology 1990;40(suppl 1):117-118."},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410340104"},{"key":"e_1_3_1_12_2","first-page":"4","volume":"52","year":"1995","unstructured":"Honnorat J, Trouillas P, Thivolet C, Aguera M, Belin MF. Autoantibodies to glutamate decarboxylase in a patient with cerebellar cortical atrophy, peripheral neuropathy, and slow eye movements. Arch Neurol 1995;52:462-468.","journal-title":"Arch Neurol"},{"key":"e_1_3_1_13_2","unstructured":"Nemni R Bonifacio E Mortara A Lampasona V Canal N. Characterisation and quantification of autoantibodies to glutamic acid decarboxylase (GAD) in neurological syndromes [abstract]. J Neurol 1996;243(suppl 2):S23."},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360105"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.130S005"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.1.4"},{"key":"e_1_3_1_17_2","doi-asserted-by":"crossref","unstructured":"Schuller E. A new strategy for the study of intrathecal immunity. In: Marrosu MG Cianchetti C Tabolato B eds. Trends in neuroimmunology. New York: Plenum Press 1990:3-12.","DOI":"10.1007\/978-1-4613-0607-8_1"},{"key":"e_1_3_1_18_2","first-page":"5","volume":"143","year":"1996","unstructured":"Giometto B, Miotto D, Faresin F, et al. Anti-gabaergic neuron autoantibodies in a patient with stiff-man syndrome and ataxia. J Neurol Sci 1996;143:57-59.","journal-title":"J Neurol Sci"},{"key":"e_1_3_1_19_2","first-page":"A","volume":"48","year":"1997","unstructured":"Brashear HR, Login IS, Mathe SA, Phillips LH. Cerebellar disorder in stiff-man syndrome [abstract]. Neurology 1997;48:A433.","journal-title":"Neurology"},{"key":"e_1_3_1_20_2","unstructured":"Dalmau J Graus F. Paraneoplastic syndromes. In: Samuels MA Feste S eds. Office practice of neurology. New York: Churchill Livingstone 1996:925-934."},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.53.1.2"},{"key":"e_1_3_1_22_2","first-page":"7","volume":"43","year":"1988","unstructured":"Thomson G, Robinson WP, Kuhner MK, et al. Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of Caucasians with insulin-dependent diabetes mellitus. Am J Hum Genet 1988;43:799-816.","journal-title":"Am J Hum Genet"},{"key":"e_1_3_1_23_2","unstructured":"Eisenbarth GS Jackson RA. The immunoendocrinopathy syndromes. In: Wilson JD Foster DW eds. Williams textbook of endocrinology. Philadelphia: WB Saunders 1992;1555-1566."},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198901053200102"},{"key":"e_1_3_1_25_2","first-page":"3","volume":"228","year":"1985","unstructured":"Borges LF, Elliott PJ, Gill R, Iversen SD, Iversen LL. Selective extraction of small and large molecules from the cerebrospinal fluid by Purkinje neurons. Science 1985;228:346-348.","journal-title":"Science"},{"key":"e_1_3_1_26_2","first-page":"3","volume":"19","year":"1969","unstructured":"Cremer GM, Goldstein NP, Paris J. Myxedema and ataxia. Neurology 1969;19:37-46.","journal-title":"Neurology"}],"container-title":["Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.neurology.org\/doi\/pdfdirect\/10.1212\/WNL.49.4.1026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T15:46:11Z","timestamp":1711554371000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.neurology.org\/doi\/10.1212\/WNL.49.4.1026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["10.1212\/WNL.49.4.1026"],"URL":"https:\/\/doi.org\/10.1212\/wnl.49.4.1026","relation":{},"ISSN":["0028-3878","1526-632X"],"issn-type":[{"value":"0028-3878","type":"print"},{"value":"1526-632X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,10]]}}}