{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:10:31Z","timestamp":1770484231813,"version":"3.49.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology"],"published-print":{"date-parts":[[1997,11]]},"DOI":"10.1212\/wnl.49.5.1331","type":"journal-article","created":{"date-parts":[[2012,5,13]],"date-time":"2012-05-13T13:30:30Z","timestamp":1336915830000},"page":"1331-1334","source":"Crossref","is-referenced-by-count":58,"title":["The common MELAS mutation A3243G in mitochondrial DNA among young patients with an occipital brain infarct"],"prefix":"10.1212","volume":"49","author":[{"given":"K.","family":"Majamaa","sequence":"first","affiliation":[{"name":"From the Departments of Neurology (Drs. Majamaa, Turkka, and Ka\u0308rppa\u0308, and Ms. Winqvist) and Medical Biochemistry (Drs. Majamaa and Hassinen), University of Oulu, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Turkka","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (Drs. Majamaa, Turkka, and Ka\u0308rppa\u0308, and Ms. Winqvist) and Medical Biochemistry (Drs. Majamaa and Hassinen), University of Oulu, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ka\u0308rppa\u0308","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (Drs. Majamaa, Turkka, and Ka\u0308rppa\u0308, and Ms. Winqvist) and Medical Biochemistry (Drs. Majamaa and Hassinen), University of Oulu, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Winqvist","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (Drs. Majamaa, Turkka, and Ka\u0308rppa\u0308, and Ms. Winqvist) and Medical Biochemistry (Drs. Majamaa and Hassinen), University of Oulu, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. E.","family":"Hassinen","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (Drs. Majamaa, Turkka, and Ka\u0308rppa\u0308, and Ms. Winqvist) and Medical Biochemistry (Drs. Majamaa and Hassinen), University of Oulu, Finland."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","first-page":"9","volume":"19","year":"1988","unstructured":"Nencini P, Inzitari D, Baruffi MC, et al. Incidence of stroke in young adults in Florence, Italy. Stroke 1988;19:977-981.","journal-title":"Stroke"},{"key":"e_1_3_1_3_2","first-page":"3","volume":"24","year":"1993","unstructured":"Carolei A, Marini C, Ferranti E, et al. A prospective study of cerebral ischemia in the young. Analysis of pathogenic determinants. Stroke 1993;24:362-367.","journal-title":"Stroke"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.1.1"},{"key":"e_1_3_1_5_2","first-page":"4","volume":"52","year":"1995","unstructured":"Adams HP Jr, Kappelle LJ, Biller J, et al. Ischemic stroke in young adults. Experience in 329 patients enrolled in the Iowa Registry of Stroke in Young Adults. Arch Neurol 1995;52:491-495.","journal-title":"Arch Neurol"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.1.1"},{"key":"e_1_3_1_7_2","first-page":"1","volume":"43","year":"1993","unstructured":"Bogousslavsky J, Regli F, Maeder P, Meuli R, Nader J. The etiology of posterior circulation infarcts: a prospective study using magnetic resonance imaging and magnetic resonance angiography. Neurology 1993;43:1528-1533.","journal-title":"Neurology"},{"key":"e_1_3_1_8_2","first-page":"4","volume":"44","year":"1987","unstructured":"Bogousslavsky J, Regli F. Ischemic stroke in adults younger than 30 years of age. Arch Neurol 1987;44:479-482.","journal-title":"Arch Neurol"},{"key":"e_1_3_1_9_2","first-page":"2","volume":"21","year":"1987","unstructured":"Pessin MS, Lathi ES, Cohen MB, et al. Clinical features and mechanism of occipital infarction. Ann Neurol 1987;21:290-299.","journal-title":"Ann Neurol"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310103"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.1.5"},{"key":"e_1_3_1_12_2","first-page":"2","volume":"26","year":"1994","unstructured":"Schon EA, Hirano M, DiMauro S. Mitochondrial encephalomyopathies: clinical and molecular analysis. J Bioenerg Biomembr 1994;26:291-299.","journal-title":"J Bioenerg Biomembr"},{"key":"e_1_3_1_13_2","doi-asserted-by":"crossref","unstructured":"Hammans SR Morgan-Hughes JA. Mitochondrial myopathies: clinical features investigation treatment and genetic councelling. In: Schapira AHV DiMauro S eds. Mitochondrial disorders in neurology. Oxford: Butterworth-Heinemann 1994:49-74.","DOI":"10.1016\/B978-0-7506-0585-4.50008-3"},{"key":"e_1_3_1_14_2","first-page":"3","volume":"24","year":"1993","unstructured":"Ooiwa Y, Uematsu Y, Terada T, et al. Cerebral blood flow in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes. Stroke 1993;24:304-309.","journal-title":"Stroke"},{"key":"e_1_3_1_15_2","first-page":"4","volume":"13","year":"1994","unstructured":"Barbiroli B, Montagna P, Martinelli P, et al. Defective brain energy metabolism shown by in vivo 31P MR spectroscopy in 28 patients with mitochondrial cytopathies. J Cereb Blood Flow Metab 1994;13:469-474.","journal-title":"J Cereb Blood Flow Metab"},{"key":"e_1_3_1_16_2","first-page":"2","volume":"16","year":"1995","unstructured":"Castillo M, Kwock L, Green C. MELAS syndrome: imaging and proton MR spectroscopic findings. AJNR Am J Neuroradiol 1995;16:233-239.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_1_17_2","first-page":"1","volume":"9","year":"1988","unstructured":"Allard JC, Tilak S, Carter AP. CT and MR of MELAS syndrome. AJNR Am J Neuroradiol 1988;9:1234-1238.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_1_18_2","first-page":"1","volume":"14","year":"1993","unstructured":"Barkovich AJ, Good WV, Koch TK, Berg BO. Mitochondrial disorders: analysis of their clinical and imaging characteristics. AJNR Am J Neuroradiol 1993;14:1119-1137.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_1_19_2","first-page":"8","volume":"173","year":"1990","unstructured":"Kobayashi Y, Momoi MY, Tominaga K, et al. A point mutation in the mitochondrial tRNALeu(UUR) gene in MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes). Biochem Biophys Res Commun 1990;173:816-822.","journal-title":"Biochem Biophys Res Commun"},{"key":"e_1_3_1_20_2","first-page":"6","volume":"53","year":"1993","unstructured":"Passarino G, Semino O, Modiano G, Santachiara-Benerecetti AS. COII\/tRNALys intergenic 9-bp deletion and other mtDNA markers clearly reveal that the Tharus (South Nepal) have Oriental affinities. Am J Hum Genet 1993;53:609-618.","journal-title":"Am J Hum Genet"},{"key":"e_1_3_1_21_2","first-page":"1","volume":"242","year":"1988","unstructured":"Wallace DC, Singh G, Lott MT, et al. Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy. Science 1988;242:1427-1430.","journal-title":"Science"},{"key":"e_1_3_1_22_2","first-page":"2","volume":"24","year":"1993","unstructured":"Adams HP Jr, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. Stroke 1993;24:25-41.","journal-title":"Stroke"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/088307389400900102"},{"key":"e_1_3_1_24_2","first-page":"4","volume":"1226","year":"1994","unstructured":"Houshmand M, Larsson NG, Holme E, et al. Automatic sequencing of mitochondrial tRNA genes in patients with mitochondrial encephalomyopathy. Biochim Biophys Acta 1994;1226:49-55.","journal-title":"Biochim Biophys Acta"},{"key":"e_1_3_1_25_2","first-page":"5","volume":"25","year":"1989","unstructured":"Sakuta R, Nonaka I. Vascular involvement in mitochondrial myopathy. Ann Neurol 1989;25:594-601.","journal-title":"Ann Neurol"},{"key":"e_1_3_1_26_2","first-page":"2","volume":"117","year":"1993","unstructured":"Muller-H\u00f6cker J, Hubner G, Bise K, et al. Generalized mitochondrial microangiopathy and vascular cytochrome c oxidase deficiency. Occurrence in a case of MELAS syndrome with mitochondrial cardiomyopathy-myopathy and combined complex I\/IV deficiency. Arch Pathol Lab Med 1993;117:202-210.","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.1.1"}],"container-title":["Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.neurology.org\/doi\/pdfdirect\/10.1212\/WNL.49.5.1331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T15:52:42Z","timestamp":1711554762000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.neurology.org\/doi\/10.1212\/WNL.49.5.1331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1997,11]]}},"alternative-id":["10.1212\/WNL.49.5.1331"],"URL":"https:\/\/doi.org\/10.1212\/wnl.49.5.1331","relation":{},"ISSN":["0028-3878","1526-632X"],"issn-type":[{"value":"0028-3878","type":"print"},{"value":"1526-632X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11]]}}}