{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:40:36Z","timestamp":1782513636904,"version":"3.54.5"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology"],"published-print":{"date-parts":[[1997,11]]},"DOI":"10.1212\/wnl.49.5.1404","type":"journal-article","created":{"date-parts":[[2012,5,13]],"date-time":"2012-05-13T13:30:30Z","timestamp":1336915830000},"page":"1404-1413","source":"Crossref","is-referenced-by-count":276,"title":["The 5-year risk of MS after optic neuritis"],"prefix":"10.1212","volume":"49","author":[{"name":"Optic Neuritis Study Group*","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199307013290101"},{"key":"e_1_3_1_3_2","first-page":"1","volume":"14","year":"1993","unstructured":"Cleary PA, Beck RW, Anderson MM, et al. Design, methods, and conduct of the Optic Neuritis Treatment Trial. Control Clin Trials 1993;14:123-142.","journal-title":"Control Clin Trials"},{"key":"e_1_3_1_4_2","first-page":"1","volume":"109","year":"1991","unstructured":"Optic Neuritis Study Group. The clinical profile of acute optic neuritis: experience of the Optic Neuritis Treatment Trial. Arch Ophthalmol 1991;109:1673-1678.","journal-title":"Arch Ophthalmol"},{"key":"e_1_3_1_5_2","first-page":"5","volume":"326","year":"1992","unstructured":"Beck RW, Cleary PA, Anderson MM, et al. A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. N Engl J Med 1992;326:581-588.","journal-title":"N Engl J Med"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.1.1"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130103"},{"key":"e_1_3_1_8_2","first-page":"8","volume":"50","year":"1993","unstructured":"Beck RW, Arrington J, Murtagh FR, Cleary PA, Kaufman DI, Optic Neuritis Study Group. Brain magnetic resonance imaging in acute optic neuritis. Experience of the Optic Neuritis Study Group. Arch Neurol 1993;50:841-846.","journal-title":"Arch Neurol"},{"key":"e_1_3_1_9_2","first-page":"1","volume":"50","year":"1966","unstructured":"Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chem Rep 1966;50:163-170.","journal-title":"Cancer Chem Rep"},{"key":"e_1_3_1_10_2","first-page":"1","volume":"34","year":"1972","unstructured":"Cox DR. Regression models and life-tables. J R Stat Soc 1972;34:187-220.","journal-title":"J R Stat Soc"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/01658109509044586"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270103"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.1.1"},{"key":"e_1_3_1_14_2","first-page":"2","volume":"39","year":"1976","unstructured":"Hutchinson WM. Acute optic neuritis and the prognosis for multiple sclerosis. J Neurol Neurosurg Psychiatry 1976;39:283-289.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_3_1_15_2","first-page":"7","volume":"50","year":"1987","unstructured":"Francis DA, Compston DAS, Batchelor JR, McDonald WI. A reassessment of the risk of multiple sclerosis developing in patients with optic neuritis after extended follow up. J Neurol Neurosurg Psychiatry 1987;50:758-765.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.1.1"},{"key":"e_1_3_1_17_2","first-page":"2","volume":"84","year":"1991","unstructured":"Martinelli V, Comi G, Filippi M, et al. Paraclinical tests in acute-onset optic neuritis: basal data and results of a short follow up. Acta Neurol Scand 1991;84:231-236.","journal-title":"Acta Neurol Scand"},{"key":"e_1_3_1_18_2","first-page":"5","volume":"80","year":"1989","unstructured":"Frederiksen JL, Larsson HBW, Henriksen O, Olesen J. Magnetic resonance imaging of the brain in patients with acute monosymptomatic optic neuritis. Acta Neurol Scan 1989;80:512-517.","journal-title":"Acta Neurol Scan"},{"key":"e_1_3_1_19_2","first-page":"6","volume":"41","year":"1991","unstructured":"Lee KH, Hashimoto SA, Hooge JP, et al. Magnetic resonance imaging of the head in the diagnosis of multiple sclerosis. A prospective 2-year follow-up with comparison of clinical evolution, evoked potentials, oligoclonal banding, and CT. Neurology 1991;41:657-660.","journal-title":"Neurology"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/116.1.1"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.12_Suppl_10.S6"},{"key":"e_1_3_1_22_2","first-page":"3","volume":"41","year":"1997","unstructured":"Jacobs LD, Kaba SE, Miller CM, Priore RL, Brownscheidle CM. Correlation of clinical, magnetic resonance imaging, and cerebrospinal fluid findings in optic neuritis. Ann Neurol 1997;41:392-398.","journal-title":"Ann Neurol"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.1.1"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.31.1.1"},{"key":"e_1_3_1_25_2","first-page":"2","volume":"45","year":"1995","unstructured":"Rodriguez M, Siva A, Cross SA, O'Brien PC, Kurland LT. Optic neuritis: a population-based study in Olmsted County, Minnesota. Neurology 1995;45:244-250.","journal-title":"Neurology"},{"key":"e_1_3_1_26_2","doi-asserted-by":"crossref","unstructured":"Kurland LT Beebe GW Kurtzke JF et al. Studies on the natural history of multiple sclerosis. 2. The progression of optic neuritis to multiple sclerosis. Acta Neurol Scand 1966;42(suppl 19):157-176.","DOI":"10.1111\/j.1600-0404.1966.tb02013.x"},{"key":"e_1_3_1_27_2","first-page":"8","volume":"213","year":"1976","unstructured":"Kahana E, Alter M, Feldman S. Optic neuritis in relation to multiple sclerosis. J Neurol 1976;213:87-95.","journal-title":"J Neurol"},{"key":"e_1_3_1_28_2","first-page":"1","volume":"114","year":"1991","unstructured":"Weinshenker BG, Rice GPA, Noseworthy JH, Carriere W, Baskerville J, Ebers GC. The natural history of multiple sclerosis: a geographically based study. Brain 1991;114:1045-1056.","journal-title":"Brain"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/116.1.1"},{"key":"e_1_3_1_30_2","unstructured":"Optic Neuritis Study Group. Visual function five years after optic neuritis: experience of the Optic Neuritis Treatment Trial. Arch Ophthalmol 1997 (in press)."}],"container-title":["Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.neurology.org\/doi\/pdfdirect\/10.1212\/WNL.49.5.1404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T15:53:33Z","timestamp":1711554813000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.neurology.org\/doi\/10.1212\/WNL.49.5.1404"}},"subtitle":["Experience of the Optic Neuritis Treatment Trial"],"short-title":[],"issued":{"date-parts":[[1997,11]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1997,11]]}},"alternative-id":["10.1212\/WNL.49.5.1404"],"URL":"https:\/\/doi.org\/10.1212\/wnl.49.5.1404","relation":{},"ISSN":["0028-3878","1526-632X"],"issn-type":[{"value":"0028-3878","type":"print"},{"value":"1526-632X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11]]}}}