{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:54:12Z","timestamp":1793228052206,"version":"4.5.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology"],"published-print":{"date-parts":[[1998,5]]},"DOI":"10.1212\/wnl.50.5.1346","type":"journal-article","created":{"date-parts":[[2012,5,13]],"date-time":"2012-05-13T13:33:32Z","timestamp":1336916012000},"page":"1346-1350","source":"Crossref","is-referenced-by-count":496,"title":["The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living"],"prefix":"10.1212","volume":"50","author":[{"given":"J. M.","family":"Gorell","sequence":"first","affiliation":[{"name":"From the Departments of Neurology (Dr. Gorell) and Biostatistics and Research Epidemiology (Drs. Johnson, Rybicki, and Peterson), Henry Ford Health System, Detroit, MI; the NIEHS Center in Molecular and Cellular Toxicology with Human Applications (Drs. Gorell and Johnson), Wayne State University, Detroit, MI; and the Toxicology Program, Department of Environmental and Industrial Health, School of Public Health (Dr. Richardson), University of Michigan, Ann Arbor, MI."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (Dr. Gorell) and Biostatistics and Research Epidemiology (Drs. Johnson, Rybicki, and Peterson), Henry Ford Health System, Detroit, MI; the NIEHS Center in Molecular and Cellular Toxicology with Human Applications (Drs. Gorell and Johnson), Wayne State University, Detroit, MI; and the Toxicology Program, Department of Environmental and Industrial Health, School of Public Health (Dr. Richardson), University of Michigan, Ann Arbor, MI."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. A.","family":"Rybicki","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (Dr. Gorell) and Biostatistics and Research Epidemiology (Drs. Johnson, Rybicki, and Peterson), Henry Ford Health System, Detroit, MI; the NIEHS Center in Molecular and Cellular Toxicology with Human Applications (Drs. Gorell and Johnson), Wayne State University, Detroit, MI; and the Toxicology Program, Department of Environmental and Industrial Health, School of Public Health (Dr. Richardson), University of Michigan, Ann Arbor, MI."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. L.","family":"Peterson","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (Dr. Gorell) and Biostatistics and Research Epidemiology (Drs. Johnson, Rybicki, and Peterson), Henry Ford Health System, Detroit, MI; the NIEHS Center in Molecular and Cellular Toxicology with Human Applications (Drs. Gorell and Johnson), Wayne State University, Detroit, MI; and the Toxicology Program, Department of Environmental and Industrial Health, School of Public Health (Dr. Richardson), University of Michigan, Ann Arbor, MI."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Richardson","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (Dr. Gorell) and Biostatistics and Research Epidemiology (Drs. Johnson, Rybicki, and Peterson), Henry Ford Health System, Detroit, MI; the NIEHS Center in Molecular and Cellular Toxicology with Human Applications (Drs. Gorell and Johnson), Wayne State University, Detroit, MI; and the Toxicology Program, Department of Environmental and Industrial Health, School of Public Health (Dr. Richardson), University of Michigan, Ann Arbor, MI."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","first-page":"3","volume":"14","year":"1996","unstructured":"Tanner CM, Goldman SM. Epidemiology of Parkinson's disease. Neurol Clin 1996;14:317-335.","journal-title":"Neurol Clin"},{"key":"e_1_3_1_3_2","first-page":"6","volume":"104","year":"1996","unstructured":"Gorell JM, DiMonte D, Graham D. The role of the environment in Parkinson's disease. Environ Health Perspect 1996;104:652-654.","journal-title":"Environ Health Perspect"},{"key":"e_1_3_1_4_2","first-page":"6","volume":"48","year":"1997","unstructured":"Gorell JM, Johnson CC, Rybicki BA, et al. Occupational exposures to metals as risk factors for Parkinson's disease. Neurology 1997;48:650-658.","journal-title":"Neurology"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000110240"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90017-5"},{"key":"e_1_3_1_7_2","first-page":"1","volume":"256","year":"1986","unstructured":"Hoar SK, Blair A, Holmes FF, et al. Agricultural herbicide use and risk of lymphoma and soft-tissue sarcoma. JAMA 1986;256:1141-1147.","journal-title":"JAMA"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000110747"},{"key":"e_1_3_1_9_2","unstructured":"Dictionary of occupational titles 4th ed. revised 1991. US Department of Labor Employment and Training Administration. Lanham MD: Bernan Press 1991."},{"key":"e_1_3_1_10_2","first-page":"9","volume":"48","year":"1991","unstructured":"Stern M, Dulaney E, Gruber SB, et al. The epidemiology of Parkinson's disease. A case-control study of young-onset and old-onset patients. Arch Neurol 1991;48:903-907.","journal-title":"Arch Neurol"},{"key":"e_1_3_1_11_2","first-page":"1","volume":"43","year":"1993","unstructured":"Butterfield PG, Valanis BG, Spencer PS, Lindeman CA, Nutt JG. Environmental antecedents of young-onset Parkinson's disease. Neurology 1993;43:1150-1158.","journal-title":"Neurology"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870090705"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.1.1"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.1.1"},{"key":"e_1_3_1_15_2","first-page":"1","volume":"43","year":"1993","unstructured":"Semchuk KM, Love EJ, Lee RG. Parkinson's disease: a test of the multifactorial etiologic hypothesis. Neurology 1993;43:1173-1180.","journal-title":"Neurology"},{"key":"e_1_3_1_16_2","first-page":"2","volume":"18","year":"1991","unstructured":"Semchuk KM, Love EJ, Lee RG. Parkinson's disease and exposure to rural environmental factors: a population-based case-control study. Can J Neurol Sci 1991;18:279-286.","journal-title":"Can J Neurol Sci"},{"key":"e_1_3_1_17_2","first-page":"4","volume":"14","year":"1987","unstructured":"Rajput AH, Uitti RJ, Stern W, et al. Geography, drinking water chemistry, pesticides and herbicides and the etiology of Parkinson's disease. Can J Neurol Sci 1987;14:414-418.","journal-title":"Can J Neurol Sci"},{"key":"e_1_3_1_18_2","first-page":"3","volume":"14","year":"1987","unstructured":"Barbeau A, Roy M, Bernier G, Campanella G, Paris S. Ecogenetics of Parkinson's disease: prevalence and environmental aspects in rural areas. Can J Neurol Sci 1987;14:36-41.","journal-title":"Can J Neurol Sci"},{"key":"e_1_3_1_19_2","unstructured":"Ecobichon DJ. Toxic effects of pesticides. In: Klaassen CD ed. Casarett and Doull's toxicology the basic science of poisons 5th ed. New York: McGraw-Hill 1996:643-689."},{"key":"e_1_3_1_20_2","doi-asserted-by":"crossref","unstructured":"Burns RS Chieuh CC Markey SP Ebert MH Jacobowitz DM Kopin IJ. A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1 2 3 6-tetrahydropyridine. Proc Natl Acad Sci USA 1983:80:4546-4550.","DOI":"10.1073\/pnas.80.14.4546"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.1.1"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360102"},{"key":"e_1_3_1_23_2","first-page":"7","volume":"63","year":"1994","unstructured":"Gerlach M, Ben-Shachar D, Riederer P, Youdim MBH. Altered brain metabolism of iron as a cause of neurodegenerative diseases? J Neurochem 1994;63:793-807.","journal-title":"Altered brain metabolism of iron as a cause of neurodegenerative diseases? J Neurochem"},{"key":"e_1_3_1_24_2","unstructured":"Corbett JR. Pesticides interfering with respiration. In: Corbett JR Wright K Baillie AC eds. The biochemical mode of action of pesticides 2nd ed. London: Academic Press 1984:1-49."},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1042\/bst022002s"},{"key":"e_1_3_1_26_2","first-page":"1","volume":"261","year":"1986","unstructured":"Thomas CE, Aust SD. Reductive release of iron from ferritin by cation free radicals of paraquat and other bipyridyls. J Biol Chem 1986;261:13064-13070.","journal-title":"J Biol Chem"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(92)90479-G"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000109772"}],"container-title":["Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.neurology.org\/doi\/pdfdirect\/10.1212\/WNL.50.5.1346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T15:24:01Z","timestamp":1711639441000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.neurology.org\/doi\/10.1212\/WNL.50.5.1346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["10.1212\/WNL.50.5.1346"],"URL":"https:\/\/doi.org\/10.1212\/wnl.50.5.1346","relation":{},"ISSN":["0028-3878","1526-632X"],"issn-type":[{"value":"0028-3878","type":"print"},{"value":"1526-632X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,5]]}}}