{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:20:57Z","timestamp":1791152457682,"version":"4.1.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology"],"published-print":{"date-parts":[[1998,7]]},"DOI":"10.1212\/wnl.51.1.41","type":"journal-article","created":{"date-parts":[[2012,5,13]],"date-time":"2012-05-13T13:34:42Z","timestamp":1336916082000},"page":"41-48","source":"Crossref","is-referenced-by-count":110,"title":["Comparison of valproate and phenobarbital treatment after status epilepticus in rats"],"prefix":"10.1212","volume":"51","author":[{"given":"A. R.","family":"Bolanos","sequence":"first","affiliation":[{"name":"From the Department of Neurology (Drs. Bolanos, Yang, Hori, Helmers, Mikati, Tandon, and Holmes, and M. Sarkisian), Harvard Medical School, Children's Hospital Boston; and the Division of Pediatric Neurology (Dr. Stafstrom), New England Medical Center, Tufts University School of Medicine, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sarkisian","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (Drs. Bolanos, Yang, Hori, Helmers, Mikati, Tandon, and Holmes, and M. Sarkisian), Harvard Medical School, Children's Hospital Boston; and the Division of Pediatric Neurology (Dr. Stafstrom), New England Medical Center, Tufts University School of Medicine, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Yang","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (Drs. Bolanos, Yang, Hori, Helmers, Mikati, Tandon, and Holmes, and M. Sarkisian), Harvard Medical School, Children's Hospital Boston; and the Division of Pediatric Neurology (Dr. Stafstrom), New England Medical Center, Tufts University School of Medicine, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hori","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (Drs. Bolanos, Yang, Hori, Helmers, Mikati, Tandon, and Holmes, and M. Sarkisian), Harvard Medical School, Children's Hospital Boston; and the Division of Pediatric Neurology (Dr. Stafstrom), New England Medical Center, Tufts University School of Medicine, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. L.","family":"Helmers","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (Drs. Bolanos, Yang, Hori, Helmers, Mikati, Tandon, and Holmes, and M. Sarkisian), Harvard Medical School, Children's Hospital Boston; and the Division of Pediatric Neurology (Dr. Stafstrom), New England Medical Center, Tufts University School of Medicine, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mikati","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (Drs. Bolanos, Yang, Hori, Helmers, Mikati, Tandon, and Holmes, and M. Sarkisian), Harvard Medical School, Children's Hospital Boston; and the Division of Pediatric Neurology (Dr. Stafstrom), New England Medical Center, Tufts University School of Medicine, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Tandon","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (Drs. Bolanos, Yang, Hori, Helmers, Mikati, Tandon, and Holmes, and M. Sarkisian), Harvard Medical School, Children's Hospital Boston; and the Division of Pediatric Neurology (Dr. Stafstrom), New England Medical Center, Tufts University School of Medicine, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. E.","family":"Stafstrom","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (Drs. Bolanos, Yang, Hori, Helmers, Mikati, Tandon, and Holmes, and M. Sarkisian), Harvard Medical School, Children's Hospital Boston; and the Division of Pediatric Neurology (Dr. Stafstrom), New England Medical Center, Tufts University School of Medicine, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. L.","family":"Holmes","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (Drs. Bolanos, Yang, Hori, Helmers, Mikati, Tandon, and Holmes, and M. Sarkisian), Harvard Medical School, Children's Hospital Boston; and the Division of Pediatric Neurology (Dr. Stafstrom), New England Medical Center, Tufts University School of Medicine, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","unstructured":"Holmes GL. Epilepsy and other seizure disorders. In: Berg B ed. Principles of pediatric neurology. New York: McGraw-Hill 1997; 223 -284."},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1988.tb04237.x"},{"key":"e_1_3_1_4_2","first-page":"25","volume":"28","year":"1986","unstructured":"Rodin EA, Schmaltz S, Twitty G. Intellectual functions of patients with childhood-onset epilepsy. Dev Med Child Neurol 1986;28:25-33.","journal-title":"Neurol"},{"key":"e_1_3_1_5_2","doi-asserted-by":"crossref","unstructured":"Holmes GL. Do seizures cause brain damage? Epilepsia 1991;32(suppl 5):S14-S28.","DOI":"10.1111\/j.1528-1157.1991.tb05886.x"},{"key":"e_1_3_1_6_2","first-page":"393","volume":"13","year":"1991","unstructured":"Holmes GL. The long-term effects of seizures on the developing brain: clinical and laboratory issues. Brain Dev 1991;13:393-409.","journal-title":"Dev"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6974(90)90071-6"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1997.tb01074.x"},{"key":"e_1_3_1_9_2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0022-3476(79)80507-7","volume":"95","year":"1979","unstructured":"Camfield CS, Chaplin S, Doyle A-B, Shapiro SH, Cummings C, Camfield PR. Side effects of phenobarbital in toddlers; behavioral and cognitive aspects. J Pediatr 1979;95:361-365.","journal-title":"Pediatr"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.80.2.165"},{"key":"e_1_3_1_11_2","first-page":"364","volume":"322","year":"1990","unstructured":"Farwell JR, Lee YJ, Hirtz DG, Sulzbacher SI, Ellenberg JH, Nelson KB. Phenobarbital for febrile seizures. Effects on intelligence and on seizure recurrence. N Engl J Med 1990;322:364-369.","journal-title":"Med"},{"key":"e_1_3_1_12_2","first-page":"19","volume":"7","year":"1983","unstructured":"Fishman RHB, Yanai J. Long-lasting effects of early barbiturates on central nervous system and behavior. Neurosci Biobehav Rev 1983;7:19-28.","journal-title":"Rev"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000240998"},{"key":"e_1_3_1_14_2","first-page":"237","volume":"64","year":"1979","unstructured":"Yanai J, Roselli-Austin L, Tabakoff B. Neuronal deficits in mice following prenatal exposure to phenobarbital. Exp Neurol 1979;64:237-244.","journal-title":"Neurol"},{"key":"e_1_3_1_15_2","first-page":"429","volume":"24","year":"1988","unstructured":"Serrano EE, Kunis DM, Ransom BR. Effects of chronic phenobarbital exposure on cultured mouse spinal cord neurons. Ann Neurol 1988;24:429-438.","journal-title":"Neurol"},{"key":"e_1_3_1_16_2","first-page":"584","volume":"9","year":"1981","unstructured":"Bergey GK, Swaiman KF, Schrier BK, Fitzgerald S, Nelson PG. Adverse effects of phenobarbital on morphological and biochemical development of fetal mouse spinal cord neurons in culture. Ann Neurol 1981;9:584-589.","journal-title":"Neurol"},{"key":"e_1_3_1_17_2","first-page":"425","volume":"36","year":"1994","unstructured":"Mikati MA, Holmes GL, Chronopoulos A, et al. Phenobarbital therapy modifies seizure related brain injury in the developing brain. Ann Neurol 1994;36:425-433.","journal-title":"Neurol"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244413"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.199.4324.90"},{"key":"e_1_3_1_20_2","first-page":"23","volume":"1","year":"1988","unstructured":"Wilks LJ, File SE, Dingemanse J. Hyperactivity and increased aggression in the rat several hours after a single dose of phenobarbital. Pharmacopsychologia 1988;1:23-31.","journal-title":"Pharmacopsychologia"},{"key":"e_1_3_1_21_2","first-page":"223","volume":"2","year":"1984","unstructured":"Pick CG, Yanai J. Long-term reduction in spontaneous alternations after early exposure to phenobarbital. Int J Development Neurosci 1984;2:223-228.","journal-title":"Neurosci"},{"key":"e_1_3_1_22_2","first-page":"967","volume":"248","year":"1989","unstructured":"Renfrey G, Schlinger H, Jakubow J, Poling A. Effects of phenytoin and phenobarbital on schedule-controlled responding and seizure activity in the amygdala-kindled rat. J Pharmacol Exp Ther 1989;248:967-973.","journal-title":"Ther"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(80)90049-4"},{"key":"e_1_3_1_24_2","first-page":"176","volume":"163","year":"1979","unstructured":"Ben-Ari Y, Lagowska J, Tremblay E, Le Gal La Salle G. A new model of focal status epilepticus: intra-amygdaloid application of kainic acid elicits repetitive secondarily generalized convulsive seizures. Brain Res 1979;163:176-179.","journal-title":"Res"},{"key":"e_1_3_1_25_2","first-page":"79","volume":"191","year":"1980","unstructured":"Ben-Ari Y, Tremblay E, Ottersen OP, Meldrum BS. The role of epileptic activity in hippocampal and 'remote' cerebral lesions induced by kainic acid. Brain Res 1980;191:79-97.","journal-title":"Res"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(84)90290-2"},{"key":"e_1_3_1_27_2","first-page":"2031","volume":"29","year":"1981","unstructured":"Nadler JV. Kainic acid as a tool for the study of temporal lobe epilepsy. Life Sci 1981;29:2031-2042.","journal-title":"Sci"},{"key":"e_1_3_1_28_2","doi-asserted-by":"crossref","unstructured":"Nadler JV Okazaki MM Gruenthal M Ault B Armstrong DR. Kainic acid seizures and neuronal cell death: insights from studies of selective lesions and drugs. In: Schwarcz R Ben-Ari Y eds. Advances in experimental medicine and biology. Excitatory amino acids and epilepsy. Vol. 203. New York: Plenum Press; 1989:673-686.","DOI":"10.1007\/978-1-4684-7971-3_51"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(85)90299-4"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-11-04173.1992"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90003-5"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(84)90288-4"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(84)90289-6"},{"key":"e_1_3_1_34_2","first-page":"227","volume":"65","year":"1992","unstructured":"Stafstrom CE, Thompson JL, Holmes GL. Kainic acid seizures in the developing brain: status epilepticus and spontaneous recurrent seizures. Dev Brain Res 1992;65:227-236.","journal-title":"Res"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1993.tb02582.x"},{"key":"e_1_3_1_36_2","first-page":"255","volume":"204","year":"1978","unstructured":"L\u00f6scher W. Serum protein binding and pharmacokinetics of valproate in man, dog, rat and mouse. J Pharmacol Exp Ther 1978;204:255-261.","journal-title":"Ther"},{"key":"e_1_3_1_37_2","first-page":"1231","volume":"5","year":"1980","unstructured":"Aly MI, Abdel-Latif A. Studies on distribution and metabolism of valproate in rat brain, liver, and kidney. Neurochem Res 1980;5:1231-1242.","journal-title":"Res"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(82)90047-8"},{"key":"e_1_3_1_39_2","first-page":"134","volume":"68","year":"1980","unstructured":"Salt TE, Tulloch IF, Walter DS. Anti-epileptic properties of sodium valproate in rat amygdaloid kindling. Br J Pharmacol 1980;68:134P.","journal-title":"Pharmacol"},{"key":"e_1_3_1_40_2","first-page":"47","volume":"11","year":"1984","unstructured":"Morris R. Development of a water maze procedure for studying spatial learning in the rat. J Neurosci Meth 1984;11:47-60.","journal-title":"Meth"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/297681a0"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1988.tb04226.x"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1977.tb04470.x"},{"key":"e_1_3_1_44_2","first-page":"255","volume":"97","year":"1987","unstructured":"Feldblum S, Ackermann RF. Increased susceptibility to hippocampal and amygdala kindling following intrahippocampal kainic acid. Exper Neurol 1987;97:255-269.","journal-title":"Neurol"}],"container-title":["Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.neurology.org\/doi\/pdfdirect\/10.1212\/WNL.51.1.41","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T15:05:51Z","timestamp":1711551951000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.neurology.org\/doi\/10.1212\/WNL.51.1.41"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,7]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,7]]}},"alternative-id":["10.1212\/WNL.51.1.41"],"URL":"https:\/\/doi.org\/10.1212\/wnl.51.1.41","relation":{},"ISSN":["0028-3878","1526-632X"],"issn-type":[{"value":"0028-3878","type":"print"},{"value":"1526-632X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,7]]}}}